{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T05:49:19Z","timestamp":1759384159611,"version":"3.37.3"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Since 2019, corneal collagen crosslinking (CXL) is included in the catalog of procedures covered by statutory health insurance in Germany. CXL is an established ophthalmological procedure for the last 20 years. The aim of this investigation was the measurement of progression before and after CXL.<\/jats:p><jats:p>\n          Material und Methods 65 consecutive eyes with progressive keratoconus from 53 patients were included in the retrospective study, which were observed at the University Eye Hospital T\u00fcbingen at least two years before and at least two years after CXL. The time of observation took place from October 2009 until March 2018. Parameters of interest had been the best corrected visual acuity (BCVA) and the keratometric values from the elevation maps measured by a Scheimpflug camera.<\/jats:p><jats:p>\n          Results 65 eyes of 53 patients had been documented. The study population included 46 (86.8%) male and 7 (13.2%) female subjects. The mean age was 24\u2009\u00b1\u20098 years. The averaged observation time between the primary consultation and CXL showed 25\u2009\u00b1\u200915 months. Preoperatively the mean BCVA pointed out in a significant increase (0.13\u2009\u00b1\u20090.17 [first visit] vs. 0.23\u2009\u00b1\u20090.22 [preOP], p\u2009&lt;\u20090.0001) while the mean Kmax resulted in a statistically significant increase (46.34\u2009\u00b1\u20093.33\u2009dpt [first visit] vs. 48.78\u2009\u00b1\u20094.17\u2009dpt [preOP], p\u2009&lt;\u20090.0001). The mean thinnest point of the cornea showed a significant decrease (490.48\u2009\u00b1\u200934.23\u2009\u00b5m [first visit] vs. 468.62\u2009\u00b1\u200929.84\u2009\u00b5m [preop], p\u2009&lt;\u20090.0001). Postoperatively the mean BCVA resulted in a significant improvement at the 12th postoperative month in comparison to the preoperative measurement (0.23\u2009\u00b1\u20090.22 [preOP] vs. 0.16\u2009\u00b1\u20090.14 [12 months], p\u2009=\u20090.04 respectively 0.17\u2009\u00b1\u20090.17 [24 months], p\u2009=\u20090.0006). The mean Kmax demonstrated in the 12th\n\t\t\t\t\tpostoperative month a significant reduction (48.78\u2009\u00b1\u20094.17\u2009dpt [preOP] vs. 47.91\u2009\u00b1\u20093.41\u2009dpt [12\u00a0months], p\u2009=\u20090.0009 respectively 48\u2009\u00b1\u20094.56\u2009dpt [24\u00a0months], p\u2009=\u20090.0051). The mean thinnest point of the cornea indicated a decrease at the 12th postoperative month\u00a0(468.62\u2009\u00b1\u200929.84\u2009\u00b5m [preOP] vs. 459.82\u2009\u00b1\u200935.88\u2009\u00b5m [12 months], p\u2009=\u20090.0078 respectively 453.47\u2009\u00b1\u200943.39\u2009\u00b5m [24\u00a0months], p\u2009=\u20090.0227).<\/jats:p><jats:p>\n          Conclusion CXL is a successful procedure for the therapy of progressive keratoconus.<\/jats:p>","DOI":"10.1055\/a-1264-7928","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:20:16Z","timestamp":1613780416000},"page":"1229-1235","source":"Crossref","is-referenced-by-count":3,"title":["Successful Regression in Patients with Progressive Keratoconus by Corneal Crosslinking"],"prefix":"10.1055","volume":"238","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0632-1724","authenticated-orcid":false,"given":"Tobias","family":"R\u00f6ck","sequence":"additional","affiliation":[{"name":"Department f\u00fcr Augenheilkunde, Universit\u00e4ts-Augenklinik, Eberhard-Karls-Universit\u00e4t T\u00fcbingen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva-Maria","family":"Konrad","sequence":"additional","affiliation":[{"name":"Department f\u00fcr Augenheilkunde, Universit\u00e4ts-Augenklinik, Eberhard-Karls-Universit\u00e4t T\u00fcbingen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"R\u00f6ck","sequence":"additional","affiliation":[{"name":"Department f\u00fcr Augenheilkunde, Universit\u00e4ts-Augenklinik, Eberhard-Karls-Universit\u00e4t T\u00fcbingen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Bramkamp","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Allgemeinmedizin, Ruhr-Universit\u00e4t Bochum, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Blumenstock","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Biometrie, Eberhard-Karls-Universit\u00e4t T\u00fcbingen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl Ulrich","family":"Bartz-Schmidt","sequence":"additional","affiliation":[{"name":"Department f\u00fcr Augenheilkunde, Universit\u00e4ts-Augenklinik, Eberhard-Karls-Universit\u00e4t T\u00fcbingen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0039-6257(97)00119-7","article-title":"Keratoconus","volume":"42","author":"Y S Rabinowitz","year":"1998","journal-title":"Surv 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University Eye Hospital in T\u00fcbingen, Germany]","volume":"117","author":"E M Konrad","year":"2020","journal-title":"Ophthalmologe"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.jcrs.2007.12.039","article-title":"Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results","volume":"34","author":"F Raiskup-Wolf","year":"2008","journal-title":"J Cataract Refract Surg"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.2147\/OPTH.S232954","article-title":"Visual and refractive long-term outcomes following standard cross-linking in progressive keratoconus management","volume":"13","author":"M Iqbal","year":"2019","journal-title":"Clin Ophthalmol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40662-016-0038-6","article-title":"Assessing progression of keratoconus: novel tomographic determinants","volume":"3","author":"J K 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management of microbial keratitis","volume":"60","author":"B I Ramona","year":"2016","journal-title":"Rom J Ophthalmol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/j.jcrs.2007.07.028","article-title":"Corneal collagen crosslinking with riboflavin and ultraviolet A to treat induced keratectasia after laser in situ keratomileusis","volume":"33","author":"F Hafezi","year":"2007","journal-title":"J Cataract Refract Surg"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","article-title":"Riboflavin\/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus","volume":"135","author":"G Wollensak","year":"2003","journal-title":"Am J Ophthalmol"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1264-7928.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T23:35:14Z","timestamp":1637105714000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1264-7928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,19]]},"references-count":39,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11,16]]},"published-print":{"date-parts":[[2021,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1264-7928","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"type":"print","value":"0023-2165"},{"type":"electronic","value":"1439-3999"}],"subject":[],"published":{"date-parts":[[2021,2,19]]}}}