{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:45:13Z","timestamp":1768275913568,"version":"3.49.0"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n                        Objective To evaluate the effect of asthma severity and disease\n                        exacerbation on pregnancy outcomes.<\/jats:p><jats:p>\n                        Materials and Methods Pregnancies were classified into 3 groups as\n                        mild (n=195), moderate (n=63), and severe (n=26)\n                        according to preconceptional asthma severity. Demographic features, clinical\n                        characteristics, and perinatal outcomes were compared between the groups.\n                        Delivery characteristics and pregnancy outcomes were also compared between\n                        the pregnancies with or without asthma exacerbation (43 and 241 pregnancies,\n                        respectively).<\/jats:p><jats:p>\n                        Results Worsening of symptoms during pregnancy was higher in moderate\n                        and severe asthma groups (p&lt;0.001). Rates of spontaneous abortion,\n                        fetal structural anomaly, preterm delivery, preeclampsia, fetal growth\n                        restriction (FGR), oligohydramnios, gestational diabetes, and intrauterine\n                        fetal demise were higher in moderate and severe asthma groups (p-values were\n                        &lt;\u20090.001, 0.01, 0.008, 0.02, 0.01, &lt;\u20090.001,\n                        &lt;\u20090.001, and 0.007, respectively). Admissions to neonatal\n                        intensive care units and neonatal complication rates were higher among\n                        moderate and severe asthma groups (p=0.035 and\n                        &lt;\u20090.001). Spontaneous abortion, preterm delivery,\n                        preeclampsia, FGR, oligohydramnios, and neonatal complication rates were\n                        higher (p&lt;0.001) in the group with exacerbated symptoms.<\/jats:p><jats:p>\n                        Conclusion Moderate to severe asthma before pregnancy and the\n                        exacerbation of asthma symptoms during pregnancy may lead to increased rates\n                        of perinatal complications.<\/jats:p>","DOI":"10.1055\/a-1264-8207","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T05:23:42Z","timestamp":1602739422000},"page":"333-340","source":"Crossref","is-referenced-by-count":10,"title":["The Effect of Asthma Severity on Perinatal Outcomes: A Tertiary\n                    Hospital Experience"],"prefix":"10.1055","volume":"225","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8209-8248","authenticated-orcid":false,"given":"Atakan","family":"Tanacan","sequence":"additional","affiliation":[{"name":"Department of Obstetric and Gynecology, Division of Perinatology,\n                    Hacettepe Universitesi Tip Fakultesi, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7953-2517","authenticated-orcid":false,"given":"Erdem","family":"Fadiloglu","sequence":"additional","affiliation":[{"name":"Department of Obstetric and Gynecology, Division of Perinatology,\n                    Hacettepe Universitesi Tip Fakultesi, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru Damadoglu","family":"Celebioglu","sequence":"additional","affiliation":[{"name":"Division of Allergic and Immunological Diseases, Department of Chest\n                    Disease, Hacettepe Universitesi Tip Fakultesi, Ankara"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazli","family":"Orhan","sequence":"additional","affiliation":[{"name":"Department of Obstetric and Gynecology, Division of Perinatology,\n                    Hacettepe Universitesi Tip Fakultesi, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canan","family":"Unal","sequence":"additional","affiliation":[{"name":"Department of Obstetric and Gynecology, Division of Perinatology,\n                    Hacettepe Universitesi Tip Fakultesi, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tolga","family":"Celik","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Hacettepe\n                    Universitesi Tip Fakultesi, Ankara"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Fuat","family":"Kalyoncu","sequence":"additional","affiliation":[{"name":"Division of Allergic and Immunological Diseases, Department of Chest\n                    Disease, Hacettepe Universitesi Tip Fakultesi, Ankara"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Sinan","family":"Beksac","sequence":"additional","affiliation":[{"name":"Department of Obstetric and Gynecology, Division of Perinatology,\n                    Hacettepe Universitesi Tip Fakultesi, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"key":"ref2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.iac.2005.10.008","article-title":"The effect of pregnancy on the course of asthma","volume":"26","author":"J C Gluck","year":"2006","journal-title":"Immunol Allergy Clin North Am"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ajog.2005.06.028","article-title":"Spirometry is related to perinatal outcomes in pregnant women with 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