{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T20:47:37Z","timestamp":1648586857765},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Was ist neu?<\/jats:title><jats:p>\n          Diagnostik\u2002Zellbasierte Verfahren (z.\u200aB. LTT, ELISPOT) sollten nicht f\u00fcr die Diagnosestellung einer Borreliose verwendet werden.<\/jats:p><jats:p>\n          Therapie\u2002Eine aktuelle randomisiert-kontrollierte Studie hat best\u00e4tigt, dass Doxycyclin- und Betalaktam-Antibiotika gleichwertig eingesetzt werden k\u00f6nnen. Es gibt keine statistisch signifikanten Unterschiede hinsichtlich neurologischer Symptome nach Therapie und Nebenwirkungen. Dementsprechend wird in der S3-Leitlinie Neuroborreliose kein Pr\u00e4parat bevorzugt empfohlen.<\/jats:p><jats:p>\n          Prognose\u2002Mehreren Studien mit Patienten mit antibiotisch behandelter Neuroborreliose zeigen im Langzeitverlauf keine erh\u00f6hte Rate an Fatigue im Vergleich zu gesunden Kontrollpersonen. Ebenso findet sich f\u00fcr Lebensqualit\u00e4t, Depression und Kognition kein Unterschied zwischen Patienten mit Neuroborreliose nach Antibiotikatherapie und gesunden Kontrollpersonen im Langzeitverlauf.\n        <\/jats:p><jats:p>\n          Prophylaxe\u2002Eine prophylaktische Antibiotikagabe nach Zeckenstich wird derzeit in Deutschland nicht empfohlen.<\/jats:p>","DOI":"10.1055\/a-1265-4397","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T22:34:30Z","timestamp":1622586870000},"page":"728-732","source":"Crossref","is-referenced-by-count":0,"title":["Lyme-Borreliose und Neuroborreliose \u2013 Was ist neu?"],"prefix":"10.1055","volume":"146","author":[{"given":"Rick","family":"Dersch","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurologie und Neurophysiologie, Universit\u00e4tsklinikum Freiburg, Medizinische Fakult\u00e4t, Albert- Ludwigs-Universit\u00e4t Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Fingerle","sequence":"additional","affiliation":[{"name":"Nationales Referenzzentrum f\u00fcr Borrelien, Bayerisches Landesamt f\u00fcr Gesundheit und Lebensmittelsicherheit, Oberschlei\u00dfheim"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"ref3","first-page":"Doc14","article-title":"Cutaneous Lyme borreliosis: Guideline of the German Dermatology Society","volume":"15","author":"H Hofmann","year":"2017","journal-title":"Ger\u00a0Med Sci GMS E-J"},{"key":"ref4","first-page":"68 p","volume-title":"Lyme-Borreliose","author":"V Fingerle","year":"2017","edition":"2. 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