{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T09:06:00Z","timestamp":1649149560703},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Was ist neu?<\/jats:title><jats:p>\n          Welche Menge an Volumenersatzstoff geben?\u2002Im Schock erfolgt die Fl\u00fcssigkeitstherapie mit Kristalloiden nach zielgerichteten Kriterien und unter Kontrolle des Laktats. Zur Wiederherstellung des Re\u00e4quilibriums ist oft eine Negativbilanz durch Fl\u00fcssigkeitsrestriktion, Schleifendiuretika und maschinelle Ultrafiltration erforderlich. Bei einer maschinellen Ultrafiltration sollten 1,75\u200aml\/kg\/h nicht \u00fcberschritten werden.<\/jats:p><jats:p>\n          Welche Volumenersatzstoffe geben?\u2002Balancierte Kristalloide sind Mittel der Wahl zur Fl\u00fcssigkeitstherapie. Neue Volumenersatzstoffe mit einer h\u00f6heren Anionenl\u00fccke haben einen alkalisierenden Effekt und k\u00f6nnen m\u00f6glicherweise die Fl\u00fcssigkeitstherapie optimieren.<\/jats:p><jats:p>\n          Welche Volumenersatzstoffe f\u00fchren zu AKI?\u2002Kochsalz f\u00fchrt aufgrund einer hyperchlor\u00e4mischen Azidose in moderaten Mengen zu einer funktionellen Einschr\u00e4nkung der renalen Filtration. In h\u00f6heren Mengen ist NaCl mit einem schlechten Outcome vergesellschaftet. HES und vermutlich auch Gelatine haben zytotoxische Effekte und k\u00f6nnen zu einer akuten Nierensch\u00e4digung f\u00fchren.<\/jats:p>","DOI":"10.1055\/a-1267-0733","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T22:33:09Z","timestamp":1628029989000},"page":"977-981","source":"Crossref","is-referenced-by-count":0,"title":["Volumentherapie und Nierensch\u00e4digung \u2013 was gibt es Neues?"],"prefix":"10.1055","volume":"146","author":[{"given":"Carsten","family":"Willam","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 4, Universit\u00e4tsklinikum Erlangen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Schley","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 4, Universit\u00e4tsklinikum 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