{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T15:47:56Z","timestamp":1757778476878},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"12","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002Acute obstructive suppurative pancreatic ductitis (AOSPD) is a suppurative pancreatic duct infection with main pancreatic duct (MPD) or accessory pancreatic duct obstruction in the absence of a pancreatic pseudocyst or necrosis, which is experienced usually in chronic pancreatitis. The diagnosis is confirmed by the finding of pancreatic duct obstruction on endoscopic retrograde cholangiopancreatography (ERCP) with evidence of infection, such as a positive pancreatic juice culture or drainage of purulent pancreatic juice.<\/jats:p><jats:p>\n          Patients and methods\u2002We studied five patients with pancreatic ductal adenocarcinoma (PDAC) and one with chronic myelogenous leukemia (CML), who suffered from AOSPD.<\/jats:p><jats:p>\n          Results\u2002Of the 281 PDAC and 39 CML patients who we treated in the past 2 years in our hospital, five with PDAC (1.8\u200a%) and one with CML (2.6\u200a%) experienced AOSPD. Each patient had fever, abdominal pain, and increased blood C-reactive protein. Pancreatography found that each patient had a MPD stricture and an upstream dilatation. Four had a disruption of the MPD in the upper stream of the stricture. Nasopancreatic drainage was successfully performed in all patients. Pancreatic juice culture was positive for Klebsiella pneumonia, Enterobacter agerogenes, or Enterococcus cloacae in four patients.<\/jats:p><jats:p>\n          Conclusion\u2002AOSPD should be considered in pancreatic malignancy with fever and abdominal pain. Prompt diagnosis of AOSPD could avoid shortening of survival of patients with an already poor prognosis by infection.<\/jats:p>","DOI":"10.1055\/a-1268-7086","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T04:12:58Z","timestamp":1605672778000},"page":"E1765-E1768","source":"Crossref","is-referenced-by-count":9,"title":["Acute obstructive suppurative pancreatic ductitis in pancreatic malignancies"],"prefix":"10.1055","volume":"08","author":[{"given":"Ryoko","family":"Shimizuguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Kikuyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terumi","family":"Kamisawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sawako","family":"Kuruma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuro","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0016-5107(95)70359-4","article-title":"Acute suppuration of the pancreatic duct","volume":"41","author":"D S Weinman","year":"1995","journal-title":"Gastrointest Endosc"},{"key":"ref2","first-page":"289","article-title":"Acute obstructive suppurative pancreatic ductitis after endoscopic retrograde cholangiopancreatography in a patient with carcinoma of the pancreatic head: a case report","volume":"113","author":"Y Isono","year":"2016","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1111\/jgh.13304","article-title":"Clinical features of acute obstructive suppurative pancreatic ductitis: A retrospective review of 20 cases","volume":"31","author":"H Kondo","year":"2016","journal-title":"J 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pancreatic duct in a patient with tropical pancreatitis","volume":"2","author":"L Deeb","year":"2008","journal-title":"Case Rep Gastroenterol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1055\/s-0032-1326450","article-title":"Acute suppurative pancreatic ductitis associated with pancreatic duct obstruction","volume":"45","author":"T Fujinaga","year":"2013","journal-title":"Endoscopy"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/MPA.0000000000000794","article-title":"Acute obstructive suppurative pancreatic ductitis associated with type 1 autoimmune pancreatitis","volume":"46","author":"T Inoue","year":"2017","journal-title":"Pancreas"},{"key":"ref10","first-page":"919452","article-title":"Acute obstructive suppurative pancreatic ductitis in all asymptomatic patient","author":"E Wali","year":"2015","journal-title":"Case Rep Med"},{"key":"ref11","first-page":"1304","article-title":"A case of intraductal papillary mucinous carcinoma found with acute obstructive suppurative pancreatic ductitis and liver abscess, and associated with a pancreatobiliary fistula","volume":"110","author":"H Nishie","year":"2013","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1292\/jvms.14-0191","article-title":"Regulation of epithelial cell tight junctions by protease-activated receptor 2","volume":"76","author":"S Enjoji","year":"2014","journal-title":"J Vet Med Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1055\/s-2001-13695","article-title":"Endoscopic treatment of postsurgical external pancreatic fistulas","volume":"33","author":"G Costamagna","year":"2001","journal-title":"Endoscopy"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S0016-5107(03)02719-6","article-title":"Successful treatment of pancreaticopleural fistula by nasopancreatic drainage and endoscopic removal of pancreatic duct calculi: A case report","volume":"59","author":"A Miyachi","year":"2004","journal-title":"Gastrointest Endosc"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/j.1440-1746.2009.06172.x","article-title":"Endoscopic transpapillary drainage for external fistulas developing after surgical or radiological pancreatic interventions","volume":"25","author":"S S Rana","year":"2010","journal-title":"J Gastroenterol Hepatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1091-255X(97)80057-1","article-title":"Transpapillary stenting for pancreaticocutaneous fistulas","volume":"1","author":"R A Kozarek","year":"1997","journal-title":"J Gastrointest Surg"}],"container-title":["Endoscopy International 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