{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:31:03Z","timestamp":1784871063126,"version":"3.55.0"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2002There is growing interest in developing impedance planimetry as a tool to enhance the clinical outcomes for endoscopic and surgical management of achalasia. The primary aim of this study was to determine whether impedance planimetry measurements can predict clinical response and reflux following peroral endoscopic myotomy (POEM). <\/jats:p><jats:p>\n          Methods\u2002A multicenter cohort study of patients with achalasia undergoing POEM was established from prospective databases and retrospective chart reviews. Patients who underwent impedance planimetry before and after POEM were included. Clinical response was defined as an Eckardt score of \u2264\u200a3. Tenfold cross-validated area under curve (AUC) values were established for the different impedance planimetry measurements associated with clinical response and reflux development. <\/jats:p><jats:p>\n          Results\u2002Of the 290 patients included, 91.7\u200a% (266\/290) had a clinical response and 39.4\u200a% (108\/274) developed reflux following POEM. The most predictive impedance planimetry measurements for a clinical response were: percent change in cross-sectional area (%\u0394CSA) and percent change in distensibility index (%\u0394DI), with AUCs of 0.75 and 0.73, respectively. Optimal cutoff values for %\u0394CSA and %\u0394DI to determine a clinical response were a change of 360\u200a% and 272\u200a%, respectively. Impedance planimetry values were much poorer at predicting post-POEM reflux, with AUCs ranging from 0.40 to 0.62.<\/jats:p><jats:p>\n          Conclusion\u2002Percent change in CSA and distensibility index were the most predictive measures of a clinical response, with a moderate predictive ability. Impedance planimetry values for predicting reflux following POEM showed weak predictive capacity. <\/jats:p>","DOI":"10.1055\/a-1268-7713","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T23:34:40Z","timestamp":1604532880000},"page":"570-577","source":"Crossref","is-referenced-by-count":12,"title":["Impedance planimetry values for predicting clinical response following peroral endoscopic myotomy"],"prefix":"10.1055","volume":"53","author":[{"given":"Robert A.","family":"Moran","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina, United States"},{"name":"Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaya I.","family":"Brewer Gutierrez","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"Rahden","sequence":"additional","affiliation":[{"name":"Department of Surgery Paracelsus, Medical Private Unviersity, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of California Irvine Health, Irvine, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ujiki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, North Shore University Health System, Evanston, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Kyung","family":"Yoo","sequence":"additional","affiliation":[{"name":"Digestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shraddha","family":"Gulati","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, King\u2019s College Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Romanelli","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Massachusetts Medical School\/Baystate, Baystate Medical Center, Springfield, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Al-Nasser","sequence":"additional","affiliation":[{"name":"Department of Surgery Paracelsus, Medical Private Unviersity, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of California Irvine Health, Irvine, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mason H.","family":"Hedberg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Chicago Medical Center, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Young","family":"Cho","sequence":"additional","affiliation":[{"name":"Digestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bu","family":"Hayee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, King\u2019s College Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Desilets","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Massachusetts Medical School\/Baystate, Baystate Medical Center, Springfield, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Filser","sequence":"additional","affiliation":[{"name":"Department of Surgery, InnKlinikum Alt\u00f6tting, Alt\u00f6tting, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Fortinsky","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of California Irvine Health, Irvine, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amyn","family":"Haji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, King\u2019s College Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Fayad","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, United 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Joseph","family":"Elmunzer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouen A.","family":"Khashab","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5009\/gnl18443","article-title":"Is EndoFLIP useful for predicting clinical outcomes after peroral endoscopic myotomy in patients with achalasia?","volume":"13","author":"G H Kim","year":"2019","journal-title":"Gut Liver"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1053\/j.gastro.2012.04.048","article-title":"Efficacy of 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