{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T17:02:47Z","timestamp":1780419767696,"version":"3.54.1"},"reference-count":61,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"name":"Youth project of Liaoning Provincial Department of Education of China","award":["JYTQN201728"],"award-info":[{"award-number":["JYTQN201728"]}]},{"name":"Project of Liaoning Provincial Department of science and Technology","award":["201602281"],"award-info":[{"award-number":["201602281"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ageing increases the occurrence and development of many diseases. Exercise is believed to be an effective way to improve ageing and skeletal muscle atrophy. However, many elderly people are unable to engage in active exercise. Whole-body vibration is a passive way of moving that is especially suitable for the elderly and people who find it inconvenient to exercise. Metabolomics is the systematic study of metabolic changes in small molecules. In this study, metabolomics studies were performed to investigate the regulatory effect of whole-body vibration on the skeletal muscles of ageing mice. After 12 weeks, we found that whole-body vibration had the most obvious effect on lipid metabolism pathways (such as linoleic acid, \u03b1-linolenic acid metabolism, glycerophospholipid metabolism pathways) in skeletal muscle of ageing mice. Through further research we found that whole-body vibration decreased the levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol and very low-density lipoprotein in blood; decreased the lipid deposition in skeletal muscle; decreased the protein expression of monocyte chemoattractant protein-1 and interleukin-6; improved the protein levels of phosphorylated insulin receptor substrate-1, phosphate phosphoinositide 3-kinase and p-AKT; improved the protein levels of klotho; and decreased the protein expression of p53. These findings reveal that whole-body vibration might postpone senility by attenuating lipid deposition and reducing chronic inflammation and the insulin resistance of skeletal muscle.<\/jats:p>","DOI":"10.1055\/a-1268-8458","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:19:07Z","timestamp":1604017147000},"page":"464-477","source":"Crossref","is-referenced-by-count":10,"title":["Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice"],"prefix":"10.1055","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9327-753X","authenticated-orcid":false,"given":"Dingwen","family":"Jiang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou"},{"name":"Department of Endocrinology, First Affiliated Hospital of Jinzhou Medical University, Jinzhou"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, First Affiliated Hospital of Jinzhou Medical University, Jinzhou"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Mechanical Engineering and Automation, Liaoning University of Technology, Jinzhou"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, First Affiliated Hospital of Jinzhou Medical University, Jinzhou"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danmeng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, First Affiliated Hospital of Jinzhou Medical University, Jinzhou"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanpeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, First Affiliated Hospital of Jinzhou Medical University, Jinzhou"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, First Affiliated Hospital of Jinzhou Medical University, Jinzhou"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.exger.2017.12.002","article-title":"Pioglitazone attenuates aging-related disorders in aged apolipoprotein E deficient mice","volume":"102","author":"D Shen","year":"2018","journal-title":"Exp Gerontol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"8362","DOI":"10.1038\/s41598-018-25382-z","article-title":"Longevity extension in drosophila through gut-brain communication","volume":"8","author":"W Susan","year":"2018","journal-title":"Sci Rep"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3165396","DOI":"10.1155\/2017\/3165396","article-title":"Impact of aging and exercise on mitochondrial quality control in skeletal muscle","volume":"2017","author":"K Yuho","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.aca.2017.11.082. Epub 2017 Dec 20","article-title":"Metabolomics studies on db\/db, diabetic mice in skeletal muscle reveal effective clearance of overloaded intermediates by exercise","volume":"1037","author":"L Xiang","year":"2018","journal-title":"Anal Chim Acta"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/gerona\/gly113","article-title":"Peroxiredoxin2 deficiency aggravates aging-induced insulin resistance and declines muscle strength","volume":"74","author":"H N Cha","year":"2019","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.pathophys.2018.05.001","article-title":"Royal jelly supplementation reduces skeletal muscle lipotoxicity and insulin resistance in aged obese rats","volume":"25","author":"IE L Metwally","year":"2018","journal-title":"Pathophysiology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cmet.2016.09.017","article-title":"Mammalian mitochondria and aging: an update","volume":"25","author":"T E Kauppila","year":"2017","journal-title":"Cell Metab"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"eaax8352","DOI":"10.1126\/sciadv.aax8352","article-title":"Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity","volume":"5","author":"D Heden Timothy","year":"2019","journal-title":"Sci Adv"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.cmet.2016.05.007","article-title":"Exercise promotes healthy aging of skeletal muscle","volume":"23","author":"G Cartee","year":"2016","journal-title":"Cell Metab"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1152\/japplphysiol.00585.2014","article-title":"Metabolomic analysis of long-term spontaneous exercise in mice suggests increased lipolysis and altered glucose metabolism when animals are at rest","volume":"117","author":"D Monleon","year":"2014","journal-title":"J Appl Physiol (1985)"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.2337\/db14-1771","article-title":"Increased skeletal muscle capillarization independently enhances insulin sensitivity in older adults after exercise training and detraining","volume":"64","author":"S J Prior","year":"2015","journal-title":"Diabetes"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"33ra37","DOI":"10.1126\/scitranslmed.3001006","article-title":"Metabolic signatures of exercise in human plasma","volume":"2","author":"G D Lewis","year":"2010","journal-title":"Sci Transl Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/PHM.0000000000000193","article-title":"Older age is associated with lower optimal vibration frequency in lower-limb muscles during whole-body vibration","volume":"94","author":"F Carlucci","year":"2015","journal-title":"Am J Phys Med Rehabil"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s12010-016-2033-8","article-title":"Whole-body vibration improves insulin resistance in db\/db mice: Amelioration of lipid accumulation and oxidative stress","volume":"179","author":"Y Liu","year":"2016","journal-title":"Appl Biochem Biotech"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e0149419","DOI":"10.1371\/journal.pone.0149419","article-title":"Whole-body vibration partially reverses aging induced increases in visceral adiposity and hepatic lipid storage in mice","volume":"11","author":"A C Reijne","year":"2016","journal-title":"PLoS One"},{"key":"ref16","first-page":"1","article-title":"Whole body vibration retards progression of atherosclerosis via insulin-like growth factor 1 in apolipoprotein E-deficient mice","volume":"2018","author":"H Wu","year":"2018","journal-title":"Biomed Res Int"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"494","DOI":"10.7150\/ijms.11364","article-title":"Changes in bone biomarkers, BMC, and insulin resistance following a 10-week whole body vibration exercise program in overweight Latino boys","volume":"12","author":"D N Erceg","year":"2015","journal-title":"Int J Med Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1055\/s-0033-1354358","article-title":"Effects of whole body vibration plus diet on insulin-resistance in middle-aged obese subjects","volume":"35","author":"A Bellia","year":"2013","journal-title":"Int J Sports Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1096\/fj.201800554RR","article-title":"Dietary epicatechin improves survival and delays skeletal muscle degeneration in aged mice","volume":"33","author":"H Si","year":"2019","journal-title":"FASEB J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1055\/a-1015-3123","article-title":"Ethical standards in sport and exercise science research: 2020 update","volume":"40","author":"D J Harriss","year":"2019","journal-title":"Int J Sports Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e1900177","DOI":"10.1002\/mnfr.201900177","article-title":"Diet-related metabolites associated with cognitive decline revealed by untargeted metabolomics in a prospective cohort","volume":"63","author":"D Y Low","year":"2019","journal-title":"Mol Nutr Food Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1039\/C5FO01191D","article-title":"The urinary metabolomics profile following the intake of meals supplemented with a cocoa extract in middle-aged obese subjects","volume":"4","author":"I Ibero-Baraibar","year":"2016","journal-title":"Food Funct"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"8825","DOI":"10.1007\/s00216-015-9041-3","article-title":"A GC\/MS-based metabolomics approach for reliable diagnosis of phenylketonuria","volume":"407","author":"X Xiong","year":"2015","journal-title":"Anal Bioanal Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.3892\/mmr.2015.3908","article-title":"Analysis of polyunsaturated fatty acids and theomega-6 inflammatory pathway in hepatic ischemia\/re-perfusion injury","volume":"12","author":"E Kirac","year":"2015","journal-title":"Mol Med Rep"},{"key":"ref25","first-page":"712949","article-title":"Cardioprotective effects of \u03c9-3 PUFAs in chronic kidney disease","volume":"2013","author":"S M Lee","year":"2013","journal-title":"Biomed Res Int"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.1021\/pr200629p","article-title":"A comprehensive untargeted metabonomic analysis of human steatotic liver tissue by RP and HILIC chromatography coupled to mass spectrometry reveals important metabolic alterations","volume":"10","author":"J C Garciacan Averas","year":"2011","journal-title":"J Proteome Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s00580-019-02955-6","article-title":"Effects of asiatic acid, an active constituent in Centella asiatica (L.): Restorative perspectives of streptozotocin-nicotinamide induced changes on lipid profile and lipid metabolic enzymes in diabetic rats","volume":"28","author":"K Swapna","year":"2019","journal-title":"Comp Clin Path"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ijcard.2016.11.093","article-title":"Dysregulated fatty acid metabolism in coronary ectasia: An extended lipidomic analysis","volume":"228","author":"U Boles","year":"2016","journal-title":"Int J Cardiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jacc.2017.12.006","article-title":"Lipids, lipoproteins, and metabolites and risk of myocardial infarction and stroke","volume":"71","author":"M V Holmes","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1080\/01480545.2017.1390580","article-title":"Phosphatidylcholine attenuated docetaxel-induced peripheral neurotoxicity in rats","volume":"41","author":"S T Kim","year":"2017","journal-title":"Drug Chem Toxicol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1097\/NEN.0000000000000116","article-title":"Lysophosphatidylcholine and amide as metabolites for detecting Alzheimer disease using ultrahigh-performance liquid chromatography quadrupole time-of-flight mass spectrometry-based metabonomics","volume":"73","author":"Y Cui","year":"2014","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.bbrc.2008.03.087","article-title":"Nanomolar concentrations of lysophospha-tidylcholine recruit monocytes and induce pro-inflammatory cytokine production in macrophages","volume":"2","author":"K E Olofsson","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1194\/jlr.M014787","article-title":"Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance","volume":"6","author":"M Han","year":"2011","journal-title":"J Lipid Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.chemolab.2013.09.001","article-title":"Metabolomics research on time-selected combination of Liuwei Dihuang and Jinkui Shenqi pills in treating kidney deficiency and aging by chemometric methods","volume":"130","author":"L Zhang","year":"2014","journal-title":"Chemometr Intell Lab Syst"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"14178","DOI":"10.1074\/jbc.M701486200","article-title":"Coupling of the de novo fatty acid biosynthesis and lipoylation pathways in mammalian mitochondria","volume":"282","author":"A Witkowski","year":"2007","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s10695-017-0442-4","article-title":"Effects of fasting on the activities and mRNA expression levels of lipoprotein lipase (LPL), hor mone-sensitive lipase (HSL) and fatty acid synthetase (FAS) in spotted seabass Lateolabrax maculatus","volume":"44","author":"H Huang","year":"2018","journal-title":"Fish Physiol Biochem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3390\/nu10050605","article-title":"Exercise and nutrition strategies to counteract sarcopenic obesity","volume":"10","author":"T Inez","year":"2018","journal-title":"Nutrients"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/MCO.0b013e328312c37d","article-title":"Sarcopenic obesity: Definition, cause and Consequences","volume":"11","author":"S Stenholm","year":"2008","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1590\/1980-5918.030.s01.ao16","article-title":"Prevalence of obesity, sarcopenic obesity and associated factors: A FIBRA Network study","volume":"30","author":"S C Moura","year":"2017","journal-title":"Fisioter Mov"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"110073","DOI":"10.1016\/j.ecoenv.2019.110073","article-title":"Study on potential toxic material base and mechanisms of hepatotoxicity induced by Dysosma versipellis based on toxicological evidence chain (TEC) concept","volume":"190","author":"C Liu","year":"2020","journal-title":"Ecotoxicol Environ Saf"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1177\/0022034510387794","article-title":"Molecular inflammation as an underlying mechanism of the aging process and age-related diseases","volume":"90","author":"H Y Chung","year":"2011","journal-title":"J Dent Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.tips.2012.02.004","article-title":"Prostaglandins and chronic inflammation","volume":"33","author":"T Aoki","year":"2012","journal-title":"Trends Pharmacol Sci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, inflammation, and insulin resistance","volume":"72","author":"J M Olefsky","year":"2010","journal-title":"Annu Rev Physiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"633","DOI":"10.33549\/physiolres.933352","article-title":"Pro-inflammatory gene expression in adipose tissue of patients with atherosclerosis","volume":"66","author":"S \u010cejkov\u00e1","year":"2017","journal-title":"Physiol Res"},{"key":"ref45","first-page":"017","article-title":"5-LO inhibition ameliorates palmitic acid\u2013induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes","volume":"7","author":"H J Kwak","year":"2017","journal-title":"Sci Rep"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4239\/wjd.v1.i3.68","article-title":"Molecular mechanisms of insulin resistance in type 2 diabetes mellitus","volume":"1","author":"V Saini","year":"2010","journal-title":"World J Diabetes"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.bbrc.2016.11.055","article-title":"Transcription profiles of type 2 diabetes in man muscle reveal insulin resistance metabolic defects, apoptosis, and molecular signatures of immune activation in response to infections","volume":"482","author":"C Wu","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"ref48","first-page":"5562","article-title":"Associations of sarcopenic obesity with the metabolic syndrome and insulin resistance over five years in older men: The Concord Health and Ageing in Men Project","volume":"21","author":"D Scott","year":"2018","journal-title":"Exp Gerontol"},{"key":"ref49","first-page":"35200","article-title":"Sarcopenic obesity or obese sarcopenia: a cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis","author":"A Kalinkovich","year":"2017","journal-title":"Ageing Res Rev"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1001\/archneurol.2012.1970","article-title":"Effects of growth hormone-releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial","volume":"69","author":"L D Baker","year":"2012","journal-title":"Arch Neurol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s12603-018-1088-3","article-title":"Associations between sarcopenic obesity and cognitive impairment in elderly chinese community-dwelling individuals","volume":"23","author":"H Wang","year":"2019","journal-title":"J Nutr Health Aging"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/jcsm.12076","article-title":"Factors associated with skeletal muscle mass, sarcopenia, and sarcopenic obesity in older adults: A multicontinent study","volume":"7","author":"S Tyrovolas","year":"2016","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ypmed.2016.08.040","article-title":"Cross-sectional associations of objectively measured physical activity and sedentary time with sarcopenia and sarcopenic obesity in older men","volume":"91","author":"D Aggio","year":"2016","journal-title":"Prev Med"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"F102","DOI":"10.1152\/ajprenal.00037.2015","article-title":"Bicarbonate sensitive calcification and lifespan of klotho-deficient mice","volume":"91","author":"C B Leibrock","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3904\/kjim.2011.26.2.113","article-title":"Klotho and the aging process","volume":"26","author":"M Kuro-o","year":"2011","journal-title":"Korean J Intern Med"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3390\/ijms19030921","article-title":"p53 as a dichotomous regulator of liver disease: the dose makes the medicine","volume":"19","author":"K Jelena","year":"2018","journal-title":"Int J Mol Sci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"e286","DOI":"10.1038\/cddis.2012.15","article-title":"Re-oxygenation causes hypoxic tumor regression through restoration of p53 wild-type conformation and post-translational modifications","volume":"3","author":"R Gogna","year":"2012","journal-title":"Cell Death Dis"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/acel.12219","article-title":"Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence","volume":"13","author":"D Tran","year":"2014","journal-title":"Aging Cell"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"34605","DOI":"10.1038\/srep34605","article-title":"IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner","volume":"6","author":"H Nishizawa","year":"2016","journal-title":"Sci Rep"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"6023","DOI":"10.3390\/ijms20236023","article-title":"p53 Isoforms in cellular senescence- and ageing-associated biological and physiological functions","volume":"20","author":"K Fujita","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.gde.2016.05.007","article-title":"Mitochondrial quality control in insulin resistance and diabetes","volume":"38","author":"J Wanagat","year":"2016","journal-title":"Curr Opin Genet Dev"}],"container-title":["International Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1268-8458.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T17:10:33Z","timestamp":1723828233000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1268-8458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,29]]},"references-count":61,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2021,5,3]]},"published-print":{"date-parts":[[2021,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1268-8458","relation":{},"ISSN":["0172-4622","1439-3964"],"issn-type":[{"value":"0172-4622","type":"print"},{"value":"1439-3964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,29]]}}}