{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T18:42:58Z","timestamp":1764873778812,"version":"3.37.3"},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"crossref","award":["grant nos. 2016GXNsFAA380280"],"award-info":[{"award-number":["grant nos. 2016GXNsFAA380280"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"crossref","award":["grant nos. 2017GXNSFAA198347"],"award-info":[{"award-number":["grant nos. 2017GXNSFAA198347"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["grant no. 81160119"],"award-info":[{"award-number":["grant no. 81160119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background To report the clinical effect of oral voriconazole only as a treatment for fungal keratitis.<\/jats:p><jats:p>\n          History and Signs Three patients (1 female and 2 males) with culture-proven fungal keratitis (1 Mucoraceae, 1 Aspergillus, 1 Fusarium) were included in this study. The patients were treated with oral voriconazole 200\u2009mg twice daily to observe the clinical response in the treatment of fungal keratitis.<\/jats:p><jats:p>\n          Therapy and Outcome The mean age of the patients was 51\u00a0years and the average treatment duration was 6 weeks. The corneal inflammation in these three patients was eliminated by oral voriconazole only.<\/jats:p><jats:p>\n          Conclusions This is the first reported case of oral voriconazole only as a treatment for fungal keratitis. We found that oral voriconazole has a significant clinical effect on the treatment of fungal keratitis.<\/jats:p>","DOI":"10.1055\/a-1268-9168","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T00:18:11Z","timestamp":1608337091000},"page":"55-59","source":"Crossref","is-referenced-by-count":5,"title":["Treating Fungal Keratitis with Oral Voriconazole Only: A Case Series"],"prefix":"10.1055","volume":"238","author":[{"given":"Di","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Guangxi Medical University First Affiliated Hospital, Nanning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaojian","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Guangxi Medical University First Affiliated Hospital, Nanning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjin","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Guangxi Medical University First Affiliated Hospital, Nanning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"103802","DOI":"10.1016\/j.micpath.2019.103802","article-title":"Fungal keratitis: Pathogenesis, diagnosis and prevention","volume":"138","author":"L Niu","year":"2020","journal-title":"Microb Pathog"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1136\/bjo.2007.136515","article-title":"Voriconazole in the treatment of fungal eye infections: a review of current literature","volume":"92","author":"S M Hariprasad","year":"2008","journal-title":"Br J Ophthalmol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1128\/CMR.16.4.730-797.2003","article-title":"Current perspectives on ophthalmic mycoses","volume":"16","author":"P A Thomas","year":"2003","journal-title":"Clin Microbiol Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.ajo.2003.11.078","article-title":"In vitro investigation of voriconazole susceptibility for keratitis and endophthalmitis fungal pathogens","volume":"137","author":"F B Marangon","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/00003226-200301000-00008","article-title":"Activity of voriconazole against corneal isolates of Scedosporium apiospermum","volume":"22","author":"K B Shah","year":"2003","journal-title":"Cornea"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1086\/497126","article-title":"Strategy of following voriconazole versus amphotericin B therapy with other licensed antifungal therapy for primary treatment of invasive aspergillosis: impact of other therapies on outcome","volume":"41","author":"T F Patterson","year":"2005","journal-title":"Clin Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1001\/archopht.122.1.42","article-title":"Determination of vitreous, aqueous, and plasma concentration of orally administered voriconazole in humans","volume":"122","author":"S M Hariprasad","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mmcr.2012.10.007","article-title":"Fungal keratitis caused by Macrophomina phaseolina \u2013 A case report","volume":"1","author":"T Premamalini","year":"2012","journal-title":"Med Mycol Case Rep"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12348-016-0072-5","article-title":"Alternaria keratitis after uneventful phacoemulsification in an otherwise healthy adult","volume":"6","author":"S Khochtali","year":"2016","journal-title":"J Ophthalmic Inflamm Infect"},{"key":"ref10","first-page":"179","article-title":"Successful Treatment of Lasiodiplodia theobromae keratitis \u2013 Assessing the Role of Voriconazole","volume":"7","author":"S TL Li","year":"2016","journal-title":"Case Rep Ophthalmol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/jof3040057","article-title":"Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision","volume":"3","author":"F Bongomin","year":"2017","journal-title":"J Fungi (Basel)"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/myc.13009","article-title":"The clinical and microbiological features and outcomes of fungal keratitis over 9 years in Sydney, Australia","volume":"63","author":"S L Watson","year":"2020","journal-title":"Mycoses"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.ajo.2005.03.030","article-title":"Successful treatment of Fusarium endophthalmitis with voriconazole and Aspergillus endophthalmitis with voriconazole plus caspofungin","volume":"140","author":"M L Durand","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1097\/ICO.0000000000001365","article-title":"Comparison of oral voriconazole versus oral ketoconazole as an adjunct to topical natamycin in severe fungal keratitis","volume":"36","author":"N Sharma","year":"2017","journal-title":"Cornea"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1080\/00365540210147642","article-title":"Successful treatment of Paecilomyces lilacinus endophthalmitis with voriconazole","volume":"34","author":"J Garbino","year":"2002","journal-title":"Scand J Infect Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1001\/archopht.121.5.735","article-title":"Voriconazole treatment of fungal scleritis and epibulbar abscess resulting from scleral buckle infection","volume":"121","author":"J E Kim","year":"2003","journal-title":"Arch Ophthalmol"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1268-9168.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T01:02:45Z","timestamp":1611795765000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1268-9168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,18]]},"references-count":16,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2021,1,27]]},"published-print":{"date-parts":[[2021,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1268-9168","relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"type":"print","value":"0023-2165"},{"type":"electronic","value":"1439-3999"}],"subject":[],"published":{"date-parts":[[2020,12,18]]}}}