{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T06:45:41Z","timestamp":1775976341578,"version":"3.50.1"},"reference-count":113,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Verf\u00fcgbarkeit von GnRH-Agonist-Implantaten bietet die M\u00f6glichkeit der reversiblen, tempor\u00e4ren Downregulation der endokrinen und germinativen Hodenfunktion bei R\u00fcden und Frettchenr\u00fcden. Diese \u00dcbersichtsarbeit liefert einen \u00dcberblick \u00fcber die zugelassene Indikation, Erzielung einer vor\u00fcbergehenden Unfruchtbarkeit bei gesunden, unkastrierten, geschlechtsreifen R\u00fcden (4,7 und 9,4\u2005mg Deslorelin) und Frettchenr\u00fcden (9,4\u2005mg Deslorelin) sowie \u00fcber verschiedene Off-Label-Indikationen. Die Off-Label-Anwendung erfordert eine strenge Indikationsstellung, Besitzeraufkl\u00e4rung und einen Therapienotstand. Off-Label-Indikationen beim R\u00fcden sind sexualhormonabh\u00e4ngiges (st\u00f6rendes) Verhalten, benigne Prostatahyperplasie, Adenome der perinealen Dr\u00fcsen und Alopezie\u202fX. Die Anwendung erfolgt beim Frettchen zur Unterdr\u00fcckung der Fertilit\u00e4t und des Zyklus, aber auch zur medikament\u00f6sen Therapie des Hyperadrenokortizismus. Bei Katze und Kater kann ebenso eine Unterdr\u00fcckung der Fortpflanzung induziert werden. Problematisch sind hier insbesondere der variable Wirkeintritt und die unterschiedliche, z.\u2005T. sehr lange Wirkdauer. W\u00e4hrend kein (ausreichend) kontrazeptiver Effekt bei m\u00e4nnlichen Kaninchen und Meerschweinchen nachgewiesen wurde, kann das Implantat den Zyklus bei weiblichen Kaninchen und Meerschweinchen sowie die Reproduktion bei Ratten beiderlei Geschlechts unterdr\u00fccken. Bei V\u00f6geln und Reptilien bestehen signifikante speziespezifische Unterschiede hinsichtlich Wirksamkeit, Wirkeintritt und Wirkdauer. Ein erfolgreicher Einsatz ist bei Huhn, Japanwachtel und Psittaziden hinsichtlich Verhinderung der Eiablage beschrieben, bei Tauben kommt es nur zur Reduktion der Eiablage. Berichte zum erfolgreichen Einsatz bei reproduktionsassoziierten Verhaltensproblemen (Federpicken, Aggressivit\u00e4t) liegen ebenfalls vor. Bei m\u00e4nnlichen Tieren einzelner Vogelspezies (Japanwachtel, Zebrafink) bewirkt das Deslorelin-Implantat eine Reduktion der Testosteronkonzentration. Therapeutisch ist der erfolgreiche Einsatz beim Wellensittich mit hormonproduzierendem Sertoli-Zell-Tumor sowie beim Truthahn zur Verhaltensmodulation und Haltungserleichterung (Reduktion der Aggression) beschrieben. Bei Leguanen unterdr\u00fcckt das Implantat die Ovaraktivit\u00e4t.<\/jats:p>","DOI":"10.1055\/a-1274-9268","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T00:41:44Z","timestamp":1607128904000},"page":"420-432","source":"Crossref","is-referenced-by-count":4,"title":["GnRH-Agonisten in der Kleintierpraxis \u2013 Was wissen wir 13 Jahre nach der EU-Zulassung?"],"prefix":"10.1055","volume":"48","author":[{"given":"Sabrina","family":"Stempel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Goericke-Pesch","sequence":"additional","affiliation":[{"name":"Reproduktionsmedizinische Einheit der Kliniken \u2013 Abteilung Kleintier, Stiftung Tier\u00e4rztliche Hochschule Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"ref2","volume-title":"Expectations of Scandinavian veterinarians and 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