{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:08Z","timestamp":1740126848209,"version":"3.37.3"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"name":"FRM","award":["grant number 40184"],"award-info":[{"award-number":["grant number 40184"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nIntroduction Skeletal muscle is a major site for whole-body glucose disposal, and determination of skeletal muscle glucose uptake is an important metabolic measurement, particularly in research focussed on interventions that impact muscle insulin sensitivity. Calculating arterial-venous difference in blood glucose can be used as an indirect measure for assessing glucose uptake. However, the possibility of multiple tissues contributing to the composition of venous blood, and the differential in glucose uptake kinetics between tissue types, suggests that sampling from different vein sites could influence the estimation of glucose uptake. This study aimed to determine the impact of venous cannula position on calculated forearm glucose uptake following an oral glucose challenge in resting and post-exercise states.<\/jats:p><jats:p>\nMaterials and Methods In 9 young, lean, males, the impact of sampling blood from two antecubital vein positions; the perforating vein (\u2018perforating\u2019 visit) and, at the bifurcation of superficial and perforating veins (\u2018bifurcation\u2019 visit), was assessed. Brachial artery blood flow and arterialised-venous and venous blood glucose concentrations were measured in 3 physiological states; resting-fasted, resting-fed, and fed following intermittent forearm muscle contraction (fed-exercise).<\/jats:p><jats:p>\nResults Following glucose ingestion, forearm glucose uptake area under the curve was greater for the \u2018perforating\u2019 than for the \u2018bifurcation\u2019 visit in the resting-fed (5.92\u00b11.56 vs. 3.69\u00b11.35\u2009mmol\/60\u2009min, P&lt;0.01) and fed-exercise (17.38\u00b17.73 vs. 11.40\u00b17.31\u2009mmol\/75\u2009min, P&lt;0.05) states.<\/jats:p><jats:p>\nDiscussion Antecubital vein cannula position impacts calculated postprandial forearm glucose uptake. These findings have implications for longitudinal intervention studies where serial determination of forearm glucose uptake is required.<\/jats:p>","DOI":"10.1055\/a-1275-4038","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T22:58:42Z","timestamp":1603493922000},"page":"49-54","source":"Crossref","is-referenced-by-count":1,"title":["Antecubital Vein Cannula Position Impacts Assessment of Forearm Glucose Uptake During an Oral Glucose Challenge in Healthy Volunteers"],"prefix":"10.1055","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6729-2704","authenticated-orcid":false,"given":"C\u00e9cile","family":"B\u00e9try","sequence":"additional","affiliation":[{"name":"Medical Research Council Versus Arthritis Centre for Musculoskeletal Ageing Research"},{"name":"Department of Diabetology, P\u00f4le DigiDune, Grenoble University Hospital, Grenoble Alpes University, Grenoble"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline V.","family":"Nixon","sequence":"additional","affiliation":[{"name":"Medical Research Council Versus Arthritis Centre for Musculoskeletal Ageing Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul L.","family":"Greenhaff","sequence":"additional","affiliation":[{"name":"Medical Research Council Versus Arthritis Centre for Musculoskeletal Ageing Research"},{"name":"NIHR Nottingham Biomedical Research Centre, School of Life Sciences, University of Nottingham, Queen\u2019s Medical Centre, Nottingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth J.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Medical Research Council Versus Arthritis Centre for Musculoskeletal Ageing Research"},{"name":"NIHR Nottingham Biomedical Research Centre, School of Life Sciences, University of Nottingham, Queen\u2019s Medical Centre, Nottingham"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"ref1","first-page":"E214","article-title":"Glucose clamp technique: a method for quantifying insulin secretion and resistance","volume":"237","author":"R A De Fronzo","year":"1979","journal-title":"Am J Physiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp","volume":"22","author":"M Matsuda","year":"1999","journal-title":"Diabetes Care"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2337\/dc06-1519","article-title":"Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test","volume":"30","author":"M A Abdul-Ghani","year":"2007","journal-title":"Diabetes 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Methodological aspects","volume":"13","author":"J P Le Floch","year":"1990","journal-title":"Diabetes Care"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1530\/EJE-17-0882","article-title":"Insulin-stimulated glucose uptake in skeletal muscle, adipose tissue and liver: A positron emission tomography study","volume":"178","author":"M-J Honka","year":"2018","journal-title":"Eur J Endocrinol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1210\/jc.2007-2737","article-title":"Effects of intrabrachial metacholine infusion on muscle capillary recruitment and forearm glucose uptake during physiological hyperinsulinemia in obese, insulin-resistant individuals","volume":"93","author":"G Murdolo","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF00505182","article-title":"Effects of growth hormone on insulin sensitivity and forearm metabolism in normal man","volume":"32","author":"N M\u00f8ller","year":"1989","journal-title":"Diabetologia"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1275-4038.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:31:08Z","timestamp":1641256268000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1275-4038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,23]]},"references-count":17,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2022,1,3]]},"published-print":{"date-parts":[[2022,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1275-4038","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"type":"print","value":"0947-7349"},{"type":"electronic","value":"1439-3646"}],"subject":[],"published":{"date-parts":[[2020,10,23]]}}}