{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T22:59:51Z","timestamp":1774393191498,"version":"3.50.1"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Orthop Unfall"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tuberculosis is one of the most common infectious diseases worldwide. The\n\t\t\t\t\tfrequency in Germany is low, however, an increase has been observed in the past\n\t\t\t\t\tfew years. The incidence of extrapulmonary manifestation accounts for up to 10\n\t\t\t\t\tto 20%. In 50% of these cases the spinal column is affected. Although literature\n\t\t\t\t\treveals worldwide experiences in the treatment, in Germany spinal tuberculosis\n\t\t\t\t\tremains a rarity. Different pitfalls and specific characteristics regarding\n\t\t\t\t\tdiagnosis and therapy are to consider. Therefore, a presentation of these\n\t\t\t\t\tspecifics and their discussion based on the available literature will be\n\t\t\t\t\tpresented. The purpose is to achieve an increase in awareness regarding this, in\n\t\t\t\t\tour latitudes, rare disease.<\/jats:p>","DOI":"10.1055\/a-1285-4994","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T23:53:51Z","timestamp":1611273231000},"page":"74-83","source":"Crossref","is-referenced-by-count":14,"title":["Spinal Tuberculosis"],"prefix":"10.1055","volume":"160","author":[{"given":"Christoph Eckhard","family":"Heyde","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Trauma Surgery and Plastic Surgery,\n\t\t\t\t\tUniversity of Leipzig Medical Faculty, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"L\u00fcbbert","sequence":"additional","affiliation":[{"name":"Department of Oncology, Gastroenterology, Hepatology, Respiratory\n\t\t\t\t\tMedicine, Infectiology, Infectious Disease and Tropical Medicine Section,\n\t\t\t\t\tUniversity of Leipzig Medical Faculty, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Wendt","sequence":"additional","affiliation":[{"name":"Department of Oncology, Gastroenterology, Hepatology, Respiratory\n\t\t\t\t\tMedicine, Infectiology, Infectious Disease and Tropical Medicine Section,\n\t\t\t\t\tUniversity of Leipzig Medical Faculty, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Rodloff","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Infection Epidemiology,\n\t\t\t\t\tUniversity of Leipzig Medical Faculty, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"V\u00f6lker","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Trauma Surgery and Plastic Surgery,\n\t\t\t\t\tUniversity of Leipzig Medical Faculty, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas H.","family":"von der H\u00f6h","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Trauma Surgery and Plastic Surgery,\n\t\t\t\t\tUniversity of Leipzig Medical Faculty, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"ref1","first-page":"729","article-title":"The Diagnosis and Treatment of Tuberculosis","volume":"116","author":"I Su\u00e1rez","year":"2019","journal-title":"Dtsch Arztebl Int"},{"issue":"S 02","key":"ref2","first-page":"S58","article-title":"Tuberculous spondylodiscitis: epidemiology, clinical features, treatment, and\n\t\t\t\t\toutcome","volume":"16","author":"E M Trecarichi","year":"2012","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00264-011-1414-4","article-title":"Tuberculosis of the spine. A systematic review of case series","volume":"36","author":"F M Fuentes","year":"2012","journal-title":"Int Orthop"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.2106\/JBJS.RVW.18.00035","article-title":"Spinal Tuberculosis: A Literature Review","volume":"7","author":"A Ali","year":"2019","journal-title":"JBJS Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1179\/2045772311Y.0000000023","article-title":"Spinal tuberculosis: a review","volume":"34","author":"R K Garg","year":"2011","journal-title":"J Spinal Cord Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00590-016-1811-x","article-title":"Spinal tuberculosis, natural history of disease, classifications and principles\n\t\t\t\t\tof management with historical perspective","volume":"26","author":"K Kumar","year":"2016","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/RMR.0000000000000032","article-title":"Spinal infections: clinical and imaging features","volume":"23","author":"A Arbelaez","year":"2014","journal-title":"Top Magn Reson Imaging"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.spinee.2019.05.002","article-title":"Spinal tuberculosis: a comprehensive review for the modern spine surgeon","volume":"19","author":"K Khanna","year":"2019","journal-title":"Spine J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e4923","DOI":"10.1097\/MD.0000000000004923","article-title":"Trends of spinal tuberculosis research (1994\u20132015): A bibliometric study","volume":"95","author":"Y Wang","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/bmb\/ldw003","article-title":"Vertebral osteomyelitis in adults: an update","volume":"117","author":"E K Nickerson","year":"2016","journal-title":"Br Med Bull"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ijantimicag.2010.03.023","article-title":"Non-pyogenic infections of the spine","volume":"36","author":"G S Skaf","year":"2010","journal-title":"Int J Antimicrob Agents"},{"key":"ref12","volume-title":"Pott Disease (Tuberculous Spondylitis)","author":"V K Viswanathan","year":"2020"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4103\/1817-1737.191867","article-title":"Multi-drug resistant tuberculous spondylitis: A review of the literature","volume":"11","author":"Q F Kizilbash","year":"2016","journal-title":"Ann Thorac Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"792","DOI":"10.4184\/asj.2016.10.4.792","article-title":"Management of Tuberculous Infection of the Spine","volume":"10","author":"P Kandwal","year":"2016","journal-title":"Asian Spine J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.rcl.2012.04.001","article-title":"Imaging of spine infection","volume":"50","author":"F E Diehn","year":"2012","journal-title":"Radiol Clin North Am"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"96S","DOI":"10.1177\/2192568218769053","article-title":"Spinal Tuberculosis: Current Concepts","volume":"8(4 Suppl.)","author":"S Rajasekaran","year":"2018","journal-title":"Global Spine J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1055\/s-0030-1255128","article-title":"Spondylodiszitis \u2013 eine interdisziplin\u00e4re Herausforderung","volume":"135","author":"K Zarghooni","year":"2010","journal-title":"Dtsch Med Wochenschr"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1136\/ard.56.12.709","article-title":"Pyogenic, tuberculous, and brucellar vertebral osteomyelitis: a descriptive and\n\t\t\t\t\tcomparative study of 219 cases","volume":"56","author":"J D Colmenero","year":"1997","journal-title":"Ann Rheum Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1302\/0301-620X.100B4.BJJ-2017-1040.R1","article-title":"Spinal tuberculosis: review of current management","volume":"100-B","author":"R N Dunn","year":"2018","journal-title":"Bone Joint J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1055\/s-0038-1628301","article-title":"Tuberkul\u00f6se Spondylitis","volume":"26","author":"K M Peters","year":"2017","journal-title":"Osteologie"},{"issue":"S 02","key":"ref21","first-page":"S8","article-title":"Imaging of spondylodiscitis","volume":"16","author":"A Leone","year":"2012","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"529","DOI":"10.5435\/JAAOS-D-13-00213","article-title":"Granulomatous Vertebral Osteomyelitis: An Update","volume":"23","author":"M R Murray","year":"2015","journal-title":"J Am Acad Orthop Surg"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/B978-0-444-53486-6.00035-1","article-title":"Infections of the spine and spinal cord","volume":"136","author":"M M Thurnher","year":"2016","journal-title":"Handb Clin Neurol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.nic.2015.01.011","article-title":"Pathologic basis of pyogenic, nonpyogenic, and other spondylitis and\n\t\t\t\t\tdiscitis","volume":"25","author":"G Esendagli-Yilmaz","year":"2015","journal-title":"Neuroimaging Clin N Am"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1055\/s-0038-1628300","article-title":"Die bakterielle unspezifische \u201epyogene\u201c Spondylodiszitis","volume":"26","author":"C-E Heyde","year":"2017","journal-title":"Osteologie"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1111\/jep.13309","article-title":"Spinal tuberculosis: A systematic review of case studies and development of an\n\t\t\t\t\tevidence-based clinical guidance tool for early detection","volume":"26","author":"Q A Louw","year":"2020","journal-title":"J Eval Clin Pract"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/sc.2016.85","article-title":"Demographics of tuberculosis of spine and factors affecting neurological\n\t\t\t\t\timprovement in patients suffering from tuberculosis of spine: a retrospective\n\t\t\t\t\tanalysis of 312 cases","volume":"55","author":"A Sharma","year":"2017","journal-title":"Spinal Cord"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1055\/s-0032-1325104","article-title":"Spondylitis und ihre Differenzialdiagnosen","volume":"8","author":"R Erlemann","year":"2013","journal-title":"Orthop\u00e4die und Unfallchirurgie up2date"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.mric.2016.04.005","article-title":"Imaging in Spondylodiskitis","volume":"24","author":"E Prodi","year":"2016","journal-title":"Magn Reson Imaging Clin N Am"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.spinee.2004.05.255","article-title":"Results of nonsurgical treatment of thoracic spinal tuberculosis in adults","volume":"5","author":"A Nene","year":"2005","journal-title":"Spine J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1177\/230949901502300328","article-title":"Review article: Surgical approaches for correction of post-tubercular\n\t\t\t\t\tkyphosis","volume":"23","author":"J R Panchmatia","year":"2015","journal-title":"J Orthop Surg (Hong Kong)"},{"issue":"05","key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004532.pub2","article-title":"Routine surgery in addition to chemotherapy for treating spinal\n\t\t\t\t\ttuberculosis","author":"P C Jutte","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"ref34","first-page":"92","article-title":"[Recommendations for personal respiratory protection in tuberculosis]","volume":"58","author":"T Schaberg","year":"2004","journal-title":"Pneumologie"}],"container-title":["Zeitschrift f\u00fcr Orthop\u00e4die und Unfallchirurgie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1285-4994.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:19:29Z","timestamp":1644538769000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1285-4994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,21]]},"references-count":33,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2022,2,10]]},"published-print":{"date-parts":[[2022,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1285-4994","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1864-6697","1864-6743"],"issn-type":[{"value":"1864-6697","type":"print"},{"value":"1864-6743","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,21]]}}}