{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:40:27Z","timestamp":1792017627423,"version":"4.4.0"},"reference-count":62,"publisher":"Georg Thieme Verlag KG","issue":"03","funder":[{"name":"Berta-Ottenstein-Programme for Advanced Clinician Scientists, Faculty of Medicine, University of Freiburg"},{"name":"Berta-Ottenstein-Programme for Advanced Clinician Scientists, Faculty of Medicine, University of Freiburg"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>Background\u2002Chondrogenic tumors are the most frequent primary bone tumors. Malignant chondrogenic tumors represent about one quarter of malignant bone tumors. Benign chondrogenic bone tumors are frequent incidental findings at imaging. Radiological parameters may be helpful for identification, characterization, and differential diagnosis.<\/jats:p><jats:p>Methods\u2002Systematic PubMed literature research. Identification and review of studies analyzing and describing imaging characteristics of chondrogenic bone tumors.<\/jats:p><jats:p>Results and conclusions\u2002The 2020 World Health Organization (WHO) classification system differentiates between benign, intermediate (locally aggressive or rarely metastasizing), and malignant chondrogenic tumors. On imaging, typical findings of differentiated chondrogenic tumors are lobulated patterns with a high signal on T2-weighted magnetic resonance imaging (MRI) and ring- and arc-like calcifications on conventional radiography and computed tomography (CT). Depending on the entity, the prevalence of this chondrogenic pattern differs. While high grade tumors may be identified due to aggressive imaging patterns, the differentiation between benign and intermediate grade chondrogenic tumors is challenging, even in an interdisciplinary approach.<\/jats:p><jats:p>Key Points:\u2002<\/jats:p><jats:p>Citation Format<\/jats:p>","DOI":"10.1055\/a-1288-1209","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T23:56:31Z","timestamp":1604620591000},"page":"262-275","source":"Crossref","is-referenced-by-count":48,"title":["Chondrogenic Bone Tumors: The Importance of Imaging Characteristics"],"prefix":"10.1055","volume":"193","author":[{"given":"Hannes","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Center \u2013 University of\u00a0Freiburg, Faculty of Medicine, University of Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg W.","family":"Herget","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Medical\u00a0Center \u2013 University of Freiburg, Faculty of\u00a0Medicine, University of\u00a0Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"F\u00fcllgraf","sequence":"additional","affiliation":[{"name":"Institute for Surgical Pathology, Medical Center \u2013 University of Freiburg, Faculty of Medicine, University of\u00a0Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Sutter","sequence":"additional","affiliation":[{"name":"Department of Radiology, Balgrist University Hospital, Zurich, Switzerland; Faculty of Medicine, University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Benndorf","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Center \u2013 University of\u00a0Freiburg, Faculty of Medicine, University of Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Bamberg","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Center \u2013 University of\u00a0Freiburg, Faculty of Medicine, University of Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2198-3678","authenticated-orcid":false,"given":"Pia M.","family":"Jungmann","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Center \u2013 University of\u00a0Freiburg, Faculty of Medicine, University of Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,11,5]]},"reference":[{"key":"ref1","first-page":"476","article-title":"Cartilage tumors: Pathology and radiomorphology","volume":"56","author":"M Uhl","year":"2016","journal-title":"Radiologe"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0033-8389(22)02844-5","article-title":"A probabilistic approach to the diagnosis of bone tumors","volume":"3","author":"G S Lodwick","year":"1965","journal-title":"Radiol Clin North Am"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1148\/rg.235035134","article-title":"From the archives of the AFIP: imaging of primary chondrosarcoma: radiologic-pathologic correlation","volume":"23","author":"M D Murphey","year":"2003","journal-title":"Radiographics"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1055\/s-0037-1606130","article-title":"ESSR Consensus Document for Detection, Characterization, and Referral Pathway for Tumors and Tumorlike Lesions of Bone","volume":"21","author":"R Lalam","year":"2017","journal-title":"Semin Musculoskelet Radiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1097\/00004728-199111000-00021","article-title":"MR of enchondroma and chondrosarcoma: rings and arcs of Gd-DTPA enhancement","volume":"15","author":"J Aoki","year":"1991","journal-title":"J Comput Assist Tomogr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1002\/cncr.28657","article-title":"Sarcoma classification: an update based on the 2013 World Health Organization Classification of Tumors of Soft Tissue and Bone","volume":"120","author":"L A Doyle","year":"2014","journal-title":"Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1038\/s41379-019-0315-8","article-title":"Synovial chondromatosis and soft tissue chondroma: extraosseous cartilaginous tumor defined by FN1 gene rearrangement","volume":"32","author":"F Amary","year":"2019","journal-title":"Mod Pathol"},{"key":"ref10","first-page":"107","article-title":"Updates to the WHO classification of bone tumours","volume":"39","author":"G Jundt","year":"2018","journal-title":"Pathologe"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"316","DOI":"10.2106\/JBJS.17.00105","article-title":"Conventional Primary Central Chondrosarcoma of the Pelvis: Prognostic Factors and Outcome of Surgical Treatment in 162 Patients","volume":"100","author":"M PA Bus","year":"2018","journal-title":"J Bone Joint Surg Am"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.suronc.2018.05.009","article-title":"Incidence, outcomes and prognostic factors during 25 years of treatment of chondrosarcomas","volume":"27","author":"V M van Praag Veroniek","year":"2018","journal-title":"Surg Oncol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1148\/radiographics.20.5.g00se171407","article-title":"Imaging of osteochondroma: variants and complications with radiologic-pathologic correlation","volume":"20","author":"M D Murphey","year":"2000","journal-title":"Radiographics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4149\/neo_2014_046","article-title":"Insights into Enchondroma, Enchondromatosis and the risk of secondary Chondrosarcoma. Review of the literature with an emphasis on the clinical behaviour, radiology, malignant transformation and the follow up","volume":"61","author":"G W Herget","year":"2014","journal-title":"Neoplasma"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.berh.2007.12.004","article-title":"Hereditary multiple exostoses and enchondromatosis","volume":"22","author":"S Pannier","year":"2008","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/01241398-200203000-00028","article-title":"Common benign lesions of bone in children and adolescents","volume":"22","author":"J S Biermann","year":"2002","journal-title":"J Pediatr Orthop"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1148\/radiol.10082120","article-title":"Improved differentiation of benign osteochondromas from secondary chondrosarcomas with standardized measurement of cartilage cap at CT and MR imaging","volume":"255","author":"S A Bernard","year":"2010","journal-title":"Radiology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.5761\/atcs.cr.12.01955","article-title":"Pneumothorax caused by costal exostosis","volume":"20","author":"K Imai","year":"2014","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"ref19","first-page":"1125","article-title":"Osteochondroma and multiple osteochondromas: recommendations on the diagnostics and follow-up with special consideration to the occurrence of secondary chondrosarcoma","volume":"53","author":"G W Herget","year":"2013","journal-title":"Radiologe"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00256-019-03268-z","article-title":"Whole-body MRI in assessing malignant transformation in multiple hereditary exostoses and enchondromatosis: audit results and literature review","volume":"49","author":"A G Jurik","year":"2020","journal-title":"Skeletal Radiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.jcot.2019.05.018","article-title":"Advances in whole body MRI for musculoskeletal imaging: Diffusion-weighted imaging","volume":"10","author":"K Lee","year":"2019","journal-title":"J Clin Orthop Trauma"},{"key":"ref22","first-page":"143","article-title":"Cartilage tumors: morphology, genetics, and current aspects of target therapy","volume":"41","author":"A Roessner","year":"2020","journal-title":"Pathologe"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jbo.2015.02.001","article-title":"Benign tumours of the bone: A review","volume":"4","author":"D N Hakim","year":"2015","journal-title":"J Bone Oncol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.2214\/AJR.07.2796","article-title":"Incidental enchondromas of the knee","volume":"190","author":"M J Walden","year":"2008","journal-title":"Am J Roentgenol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2020.02.004","article-title":"Are the tubular bones of the hand really the commonest site for an enchondroma?","author":"A M Davies","year":"2020","journal-title":"Clin Radiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1750-1172-1-37","article-title":"Ollier disease","volume":"1","author":"C Silve","year":"2006","journal-title":"Orphanet J Rare Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00776-007-1152-z","article-title":"Secondary chondrosarcoma in cartilage bone tumors: report of 32 patients","volume":"12","author":"M Altay","year":"2007","journal-title":"J Orthop Sci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1634\/theoncologist.2011-0200","article-title":"Incidence, predictive factors, and prognosis of chondrosarcoma in patients with Ollier disease and Maffucci syndrome: an international multicenter study of 161 patients","volume":"16","author":"S H Verdegaal","year":"2011","journal-title":"Oncologist"},{"key":"ref29","first-page":"1267","article-title":"Cartilage tumors. 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Oncol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.clinimag.2012.08.006","article-title":"MR differentiation of low-grade chondrosarcoma from enchondroma","volume":"37","author":"B B Choi","year":"2013","journal-title":"Clin Imaging"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s00330-013-3003-y","article-title":"MRI differentiation of low-grade from high-grade appendicular chondrosarcoma","volume":"24","author":"H Douis","year":"2014","journal-title":"Eur Radiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1148\/radiographics.18.5.9747616","article-title":"Enchondroma versus chondrosarcoma in the appendicular skeleton: differentiating features","volume":"18","author":"M D Murphey","year":"1998","journal-title":"Radiographics"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s00330-017-4947-0","article-title":"What are the differentiating clinical and MRI-features of enchondromas from low-grade chondrosarcomas?","volume":"28","author":"H Douis","year":"2018","journal-title":"Eur Radiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00256-009-0675-0","article-title":"Cortical scalloping and cortical penetration by small eccentric chondroid lesions in the long tubular bones: not a sign of malignancy?","volume":"38","author":"K L Bui","year":"2009","journal-title":"Skeletal Radiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.crad.2019.08.017","article-title":"A retrospective validation of an imaging protocol for the management of solitary central cartilage tumours of the proximal humerus and around the knee","volume":"74","author":"A M Davies","year":"2019","journal-title":"Clin Radiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s00256-015-2123-7","article-title":"Is there a role for diffusion-weighted MRI (DWI) in the diagnosis of central cartilage tumors?","volume":"44","author":"H Douis","year":"2015","journal-title":"Skeletal Radiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1148\/radiology.214.2.r00fe12539","article-title":"Cartilaginous tumors: fast contrast-enhanced MR imaging","volume":"214","author":"M J Geirnaerdt","year":"2000","journal-title":"Radiology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1007\/s00330-013-2913-z","article-title":"Dynamic contrast-enhanced MR imaging for differentiation between enchondroma and chondrosarcoma","volume":"23","author":"T De Coninck","year":"2013","journal-title":"Eur Radiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s00330-017-5014-6","article-title":"Diagnostic value of MRI-based 3D texture analysis for tissue characterisation and discrimination of low-grade chondrosarcoma from enchondroma: a pilot study","volume":"28","author":"C S Lisson","year":"2018","journal-title":"Eur Radiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/RLI.0000000000000486","article-title":"Magnetic Resonance Imaging-Based Grading of Cartilaginous Bone Tumors: Added Value of Quantitative Texture Analysis","volume":"53","author":"B Fritz","year":"2018","journal-title":"Invest Radiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00256-017-2685-7","article-title":"F-18 FDG PET differentiation of benign from malignant chondroid neoplasms: a systematic review of the literature","volume":"46","author":"T K Subhawong","year":"2017","journal-title":"Skeletal Radiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/RLU.0000000000001947","article-title":"18F-FDG PET\/CT in Diagnostic and Prognostic Evaluation of Patients With Suspected Recurrence of Chondrosarcoma","volume":"43","author":"S K Vadi","year":"2018","journal-title":"Clin Nucl Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s12149-019-01392-3","article-title":"(18)F-FDG PET\/CT in the evaluation of cartilaginous bone neoplasms: the added value of tumor grading","volume":"33","author":"A Annovazzi","year":"2019","journal-title":"Ann Nucl Med"},{"issue":"S 02","key":"ref49","first-page":"223","article-title":"Cartilage tumors of the skeleton","volume":"29","author":"G Jundt","year":"2008","journal-title":"Pathologe"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1055\/s-0038-1675550","article-title":"Chondroid Tumors as Incidental Findings and Differential Diagnosis between Enchondromas and Low-grade Chondrosarcomas","volume":"23","author":"P D Afonso","year":"2019","journal-title":"Semin Musculoskelet Radiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jbo.2016.07.002","article-title":"Osteochondromyxoma: Review of a rare carney complex criterion","volume":"5","author":"T Golden","year":"2016","journal-title":"J Bone Oncol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1148\/rg.306105514","article-title":"Subungual tumors: clinicopathologic correlation with US and MR imaging findings","volume":"30","author":"H J Baek","year":"2010","journal-title":"Radiographics"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s11999-013-3345-4","article-title":"Subungual exostosis of the toes: a systematic review","volume":"472","author":"M P DaCambra","year":"2014","journal-title":"Clin Orthop Relat Res"},{"key":"ref54","first-page":"138","article-title":"Bizarre parosteal osteochondromatous proliferation: 16 Cases with a focus on histologic variability","volume":"15","author":"M Cocks","year":"2018","journal-title":"J\u00a0Orthop"},{"key":"ref55","first-page":"1065","article-title":"Nora\u2019s lesion. Discussion of a rare bone proliferation","volume":"39","author":"D Adler","year":"2010","journal-title":"Orthopade"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"20160088","DOI":"10.1259\/bjr.20160088","article-title":"Imaging features of chondromyxoid fibroma: report of 15 cases and literature review","volume":"89","author":"S Cappelle","year":"2016","journal-title":"Br J Radiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/PAS.0000000000001019","article-title":"Chondromyxoid Fibroma Arising in Craniofacial Sites: A Clinicopathologic Analysis of 25 Cases","volume":"42","author":"D M Meredith","year":"2018","journal-title":"Am J Surg Pathol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1258\/ar.2011.110180","article-title":"MRI of chondromyxoid fibroma","volume":"52","author":"H S Kim","year":"2011","journal-title":"Acta Radiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.clinimag.2020.01.022","article-title":"Secondary aneurysmal bone cysts and associated primary lesions: imaging features of 49 cases","volume":"62","author":"L B Gutierrez","year":"2020","journal-title":"Clin Imaging"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"867","DOI":"10.5858\/arpa.2016-0281-RS","article-title":"Chondroblastoma: An Update","volume":"141","author":"W Chen","year":"2017","journal-title":"Arch Pathol Lab Med"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s00292-017-0397-3","article-title":"Chondroblastoma","volume":"39","author":"G Jundt","year":"2018","journal-title":"Pathologe"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1148\/rg.275075116","article-title":"Imaging of synovial chondromatosis with radiologic-pathologic correlation","volume":"27","author":"M D Murphey","year":"2007","journal-title":"Radiographics"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1148\/radiographics.12.4.1636034","article-title":"Chondrosarcoma: MR imaging with pathologic correlation","volume":"12","author":"D G Varma","year":"1992","journal-title":"Radiographics"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1007\/s00330-009-1493-4","article-title":"Differentiating high-grade from low-grade chondrosarcoma with MR imaging","volume":"19","author":"H J Yoo","year":"2009","journal-title":"Eur Radiol"}],"container-title":["R\u00f6Fo - Fortschritte auf dem Gebiet der R\u00f6ntgenstrahlen und der bildgebenden Verfahren"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1288-1209.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T22:32:28Z","timestamp":1669501948000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1288-1209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,5]]},"references-count":62,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2021,2,18]]},"published-print":{"date-parts":[[2021,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1288-1209","relation":{},"ISSN":["1438-9029","1438-9010"],"issn-type":[{"value":"1438-9029","type":"print"},{"value":"1438-9010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,5]]}}}