{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T02:29:37Z","timestamp":1775183377683,"version":"3.50.1"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nBackground Hematological parameters have been investigated as being indicative of increased inflammatory response in morbidity of very preterm infants. This study aims to determine whether the hematologic parameters and ratios of preterms can be an indicative risk factor for the development of retinopathy of prematurity (ROP).<\/jats:p><jats:p>\nMaterials-Methods This retrospective cohort study examined newborns born before 32 weeks. Twenty-three patients treated with the diagnosis of ROP were included in the patient group. The control group included 23 patients who did not have ROP (no-ROP). Medical records of eligible preterm infants were retrospectively reviewed. Hemogram samples obtained from all patients during the first 24\u2009h of life and samples of their mothers obtained before delivery were evaluated. The hemogram parameters of white blood cell (WBC) count, neutrophil\/lymphocyte ratio, platelet\/lymphocyte ratio, lymphocyte\/monocyte ratio, and platelet mass index were calculated.<\/jats:p><jats:p>\nResults No difference was observed between the groups in terms of demographic data. In terms of hematological parameters, maternal WBC counts of ROP patients were significantly higher than those of no-ROP patients and WBC counts of ROP patients were significantly lower than those of no-ROP patients.<\/jats:p><jats:p>\nConclusions This study found that high WBC counts in mothers before delivery and\/or low WBC counts in preterms during the first postnatal day were higher in developed ROP. These results could lead to the development of prospective studies to assess the real prognostic value of WBC in ROP.<\/jats:p>","DOI":"10.1055\/a-1289-0105","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T23:39:25Z","timestamp":1605742765000},"page":"216-220","source":"Crossref","is-referenced-by-count":15,"title":["Can Hematological Parameters be a Indicator Risk Factor in the Development of Retinopathy of Prematurity?"],"prefix":"10.1055","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4522-6885","authenticated-orcid":false,"given":"Kiymet","family":"Celik","sequence":"additional","affiliation":[{"name":"Neonatology, Akdeniz University, Antalya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilbade","family":"Ekinci","sequence":"additional","affiliation":[{"name":"Ophthalmolgy, Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammet","family":"Asena","sequence":"additional","affiliation":[{"name":"Pediatry, Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilufer Okur","family":"Matur","sequence":"additional","affiliation":[{"name":"Neonatology, Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1080\/01443615.2017.1342614","article-title":"Maternal leukocytosis after antenatal corticosteroid administration: a systematic review and meta-analysis","volume":"38","author":"M E Bauer","year":"2018","journal-title":"J Obstet Gynaecol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e229","DOI":"10.1097\/MPH.0000000000001059","article-title":"The Value of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis","volume":"40","author":"E Can","year":"2018","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/aos.12049","article-title":"The pathophysiology of retinopathy of prematurity: an update of previous and recent knowledge","volume":"92","author":"G Cavallaro","year":"2014","journal-title":"Acta Ophthalmol"},{"key":"ref4","first-page":"1","article-title":"Use of mean platelet volume in the assessment of intrauterine infection in newborns with combined thrombocytopenia and leukopenia at birth","volume":"24","author":"C Y Chen","year":"2019","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10456-007-9066-0","article-title":"Retinopathy of prematurity","volume":"10","author":"J Chen","year":"2007","journal-title":"Angiogenesis."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/MOP.0b013e3283423f35","article-title":"Current update on retinopathy of prematurity: screening and treatment","volume":"23","author":"J Chen","year":"2011","journal-title":"Curr Opin Pediatr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12887-019-1515-6","article-title":"Neonatal hematological parameters and the risk of moderate-severe bronchopulmonary dysplasia in extremely premature infants","volume":"19","author":"X Chen","year":"2019","journal-title":"BMC Pediatr"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12967-015-0409-0","article-title":"Prognostic value of pre-operative inflammatory response biomarkers in gastric cancer patients and the construction of a predictive model","volume":"13","author":"Q Deng","year":"2015","journal-title":"J Transl Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0022-3476(05)83294-9","article-title":"Increased incidence of sepsis at birth in neutropenic infants of mothers with preeclampsia","volume":"125","author":"M W Doron","year":"1994","journal-title":"J Pediatr"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1001\/archopht.121.12.1684","article-title":"Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial","volume":"121","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1677\/joe.0.1440109","article-title":"Endotoxin administration decreases plasma insulin-like growth factor [IGF]-I and IGF-binding protein-2 in Angus x Hereford steers independent of changes in nutritional intake","volume":"144","author":"T H Elsasser","year":"1995","journal-title":"J Endocrinol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/0002-9378(91)90707-X","article-title":"Progress in pathogenesis and management of clinical intraamniotic infection","volume":"164","author":"R S Gibbs","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/s41372-019-0357-2","article-title":"Prenatal and postnatal inflammation-related risk factors for retinopathy of prematurity","volume":"39","author":"G P Goldstein","year":"2019","journal-title":"J Perinatol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1056\/NEJMra1208129","article-title":"Mechanisms and management of retinopathy of prematurity","volume":"367","author":"M E Hartnett","year":"2012","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/S0140-6736(13)60178-6","article-title":"Retinopathy of prematurity","volume":"382","author":"A Hellstr\u00f6m","year":"2013","journal-title":"Lancet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1034\/j.1600-0420.1998.760216.x","article-title":"Neonatal risk factors for retinopathy of prematurity a population-based study","volume":"76","author":"G Holmstrom","year":"1998","journal-title":"Acta Ophthalmol Scand"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/j.jacc.2005.02.054","article-title":"Which white blood cell subtypes predict increased cardiovascular risk?","volume":"45","author":"B D Horne","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"ref18","first-page":"1716","article-title":"The prognostic value of lymphocyte-to-monocyte ratio in retinopathy of prematurity","volume":"10","author":"Y X Hu","year":"2017","journal-title":"Int J Ophthalmol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e736","DOI":"10.1542\/peds.2009-2017","article-title":"Outcome of early-onset sepsis in a national cohort of very low birth weight infants","volume":"125","author":"G Klinger","year":"2010","journal-title":"Pediatrics"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jaapos.2015.04.008","article-title":"Serum neutrophil-to-lymphocyte ratio in retinopathy of prematurity","volume":"19","author":"B E Kurtul","year":"2015","journal-title":"J AAPOS"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.siny.2011.08.007","article-title":"Perinatal infection, inflammation, and retinopathy of prematurity","volume":"17","author":"J Lee","year":"2012","journal-title":"Semin Fetal Neonatal Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1001\/archsurg.134.12.1325","article-title":"Proinflammatory mediators stimulate neutrophil-directed angiogenesis","volume":"134","author":"M McCourt","year":"1999","journal-title":"Arch Surg"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1055\/s-2007-993886","article-title":"Preeclampsia does not increase the risk for culture proven sepsis in very low birth weight infants","volume":"16","author":"D A Paul","year":"1999","journal-title":"Am J Perinatol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12974-017-0943-1","article-title":"Retinopathy of prematurity: inflammation, choroidal degeneration, and novel promising therapeutic strategies","volume":"14","author":"J C Rivera","year":"2017","journal-title":"J Neuroinflammation"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1159\/000330174","article-title":"Understanding retinopathy of prematurity: update on pathogenesis","volume":"100","author":"J C Rivera","year":"2011","journal-title":"Neonatology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"B Sibai","year":"2005","journal-title":"Lancet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1203\/PDR.0b013e3181d01a36","article-title":"NICHD Neonatal Research Network: Perinatal systemic inflammatory response syndrome and retinopathy of prematurity","volume":"67","author":"B G Sood","year":"2010","journal-title":"Pediatr Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.clineuro.2019.03.012","article-title":"Peripheral blood neutrophil-to-lymphocyte ratio in preterm infants with intraventricular hemorrhage","volume":"180","author":"A A Stein","year":"2019","journal-title":"Clin Neurol Neurosurg"},{"key":"ref29","first-page":"491","article-title":"Association between neutrophil\/lymphocyte ratio with ductus arteriosus patency in preterm newborns","volume":"118","author":"M T Temel","year":"2017","journal-title":"Bratisl Lek Listy"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/hdi.12065","article-title":"The relationship between neutrophil-to-lymphocyte ratio and vascular calcification in end-stage renal disease patients","volume":"18","author":"K Turkmen","year":"2014","journal-title":"Hemodial Int"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s00417-011-1648-2","article-title":"Effects of maternal and placental inflammation on retinopathy of prematurity","volume":"250","author":"S J Woo","year":"2012","journal-title":"Graefes Arch Clin Exp Ophthalmol"}],"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1289-0105.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T22:47:24Z","timestamp":1631573244000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1289-0105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,18]]},"references-count":31,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2021,9,13]]},"published-print":{"date-parts":[[2021,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1289-0105","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"value":"0300-8630","type":"print"},{"value":"1439-3824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,18]]}}}