{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T15:13:24Z","timestamp":1714230804837},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nBackground Lead is a hazardous heavy metal, which causes many problems in the human body. Unfortunately, recent reports showed that smugglers and opium sellers add lead to drugs during the production procedure in order to increase its weight and cost.<\/jats:p><jats:p>\nPurpose The aim of this study was development of a rapid and accurate method for measurement of blood lead levels (BLL) in the oral and inhaled opiate abuser people.<\/jats:p><jats:p>\nMethods BLL in samples obtained from the oral and inhaled opium addicted patients referring to Sina Hospital in Tabriz, Iran, during 2017 was compared with healthy control group (N=15). The wet digestion method was used to prepare whole blood and Mercury Droplet Electrode Polarography (MDEP) method was utilized for measurement of the lead content of digested samples.<\/jats:p><jats:p>\nResults Results showed that there were significant differences between the BLL of samples obtained from oral (17.12\u00b174.61\u2009\u03bcg\/dL, p&lt;0.0003) and inhaled (19.33\u00b12.257\u2009\u03bcg\/dL, p&lt;0.0001) opium addicted groups in comparison with healthy control group (4.669\u00b10.3367\u2009\u03bcg\/dL).<\/jats:p><jats:p>\nConclusion Based on the results of this study it was observed that BLL in opium addicted people needs to be measured as soon as possible. Furthermore, screening of blood lead concentrations in opium-addicted people with a rapid and accurate MDEP method is very necessary and important.<\/jats:p>","DOI":"10.1055\/a-1293-6924","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T01:43:52Z","timestamp":1605231832000},"page":"193-198","source":"Crossref","is-referenced-by-count":1,"title":["A Rapid Mercury Droplet Electrode Polarography Method for Determination of Blood Lead Level in Lead Poisoned People"],"prefix":"10.1055","volume":"71","author":[{"given":"Golriz","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jalal","family":"Hanaie","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ostadi","sequence":"additional","affiliation":[{"name":"Sian Hospital, Department of Internal Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javad","family":"Valipor","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Chemistry, Tabriz University, Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliasghar","family":"Hamidi","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran"},{"name":"Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Ghanbarzadeh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ijheh.2005.01.028","article-title":"Blood lead levels and risk factors for lead poisoning in children and caregivers in Chuuk State, Micronesia","volume":"208","author":"L M Brown","year":"2005","journal-title":"International Journal of Hygiene and Environmental Health"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0013-9351(03)00036-7","article-title":"The effect of lead-based paint hazard remediation on blood lead levels of lead poisoned children in New York City","volume":"92","author":"J Leighton","year":"2003","journal-title":"Environmental Research"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"100757","DOI":"10.1016\/j.cppeds.2020.100757","article-title":"Severe lead poisoning requiring hospitalization: A case report","author":"B Stierman","year":"2020","journal-title":"Current Problems in Pediatric and Adolescent Health Care"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jtemb.2019.04.016","article-title":"Lead poisoning due to ingestion of lead-contaminated opium: A diagnostic study on patients\u2019 imaging findings","volume":"55","author":"N Zamani","year":"2019","journal-title":"Journal of Trace Elements in Medicine and Biology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"105379","DOI":"10.1016\/j.envint.2019.105379","article-title":"Blood lead levels among Chinese children: The shifting influence of industry, traffic, and e-waste over three decades","volume":"135","author":"Y Zhang","year":"2020","journal-title":"Environment International"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.scitotenv.2019.03.123","article-title":"Blood and bone lead levels in South Africa\u2019s Gyps vultures: Risk to nest-bound chicks and comparison with other avian taxa","volume":"669","author":"L van den Heever","year":"2019","journal-title":"Science of The Total Environment"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1515\/intox-2015-0009","article-title":"Lead toxicity: A review","volume":"8","author":"A L Wani","year":"2015","journal-title":"Interdisciplinary Toxicology"},{"key":"ref11","first-page":"e69","article-title":"Blood Lead Levels in Asymptomatic Opium Addict Patients; 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