{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T02:55:12Z","timestamp":1722394512694},"reference-count":13,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"abstract":"<jats:p>\n            Background\u2002CT is important in the care of patients with COVID-19 pneumonia. However, CT morphology can change significantly over the course of the disease. To evaluate the CT morphology of RT-PCR-proven COVID-19 pneumonia in a German cohort with special emphasis on identification of potential differences of CT features depending on duration and severity of disease.<\/jats:p><jats:p>\n            Method\u2002All patients with RT-PCR-proven COVID-19 pneumonia and chest CT performed between March 1 and April 15, 2020 were retrospectively identified. The CT scans were evaluated regarding the presence of different CT features (e.\u200ag. ground glass opacity, consolidation, crazy paving, vessel enlargement, shape, and margin of opacifications), distribution of lesions in the lung and extent of parenchymal involvement. For subgroup analyses the patients were divided according to the percentage of parenchymal opacification (0\u201333\u200a%, 34\u201366\u200a%, 67\u2013100\u200a%) and according to time interval between symptom onset and CT date (0\u20135\u200ad, 6\u201310\u200ad, 11\u201315\u200ad, &gt;\u200a15\u200ad). Differences in CT features and distribution between subgroups were tested using the Mantel-Haenszel Chi Squared for trend.<\/jats:p><jats:p>\n            Results\u2002The frequency of CT features (ground glass opacity, consolidation, crazy paving, bronchial dilatation, vessel enlargement, lymphadenopathy, pleural effusion) as well as pattern of parenchymal involvement differed significantly depending on the duration of disease and extent of parenchymal involvement. The early phase of disease was characterized by GGO and to a lesser extent consolidation. The opacifications tended to be round and to some extent with sharp margins and a geographic configuration. The vessels within\/around the opacifications were frequently dilated. Later on, the frequency of consolidation and especially crazy paving increased, and the round\/geographic shape faded. After day 15, bronchial dilatation occurred, and lymphadenopathy and pleural effusion were seen more frequently than before.<\/jats:p><jats:p>\n            Conclusion\u2002The prevalence of CT features varied considerably during the course of disease and depending on the severity of parenchymal involvement. Radiologists should take into account the time interval between symptom onset and date of CT and the severity of disease when discussing the likelihood of COVID-19 pneumonia based on CT morphology.<\/jats:p><jats:p>\n            Key Points:\u2002<\/jats:p><jats:p>\n            Citation Format\n          <\/jats:p>","DOI":"10.1055\/a-1293-9163","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T01:49:22Z","timestamp":1608256162000},"source":"Crossref","is-referenced-by-count":1,"title":["CT Features of COVID-19 Pneumonia Differ Depending on the Severity and Duration of Disease"],"prefix":"10.1055","author":[{"given":"Jan","family":"Schaible","sequence":"additional","affiliation":[{"name":"Regensburg University Medical Center, Department of Radiology, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Meiler","sequence":"additional","affiliation":[{"name":"Regensburg University Medical Center, Department of Radiology, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Poschenrieder","sequence":"additional","affiliation":[{"name":"Regensburg University Medical Center, Department of Radiology, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Scharf","sequence":"additional","affiliation":[{"name":"Regensburg University Medical Center, Department of Radiology, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Zeman","sequence":"additional","affiliation":[{"name":"Regensburg University Medical Center, Center for Clinical Studies, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Knobloch","sequence":"additional","affiliation":[{"name":"Regensburg University Medical Center, Department of Radiology, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine","family":"Rennert","sequence":"additional","affiliation":[{"name":"Regensburg University Medical Center, Department of Radiology, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Pregler","sequence":"additional","affiliation":[{"name":"Regensburg University Medical Center, Department of Radiology, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Kleine","sequence":"additional","affiliation":[{"name":"Hospital Barmherzige Br\u00fcder, Department of Pneumology, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Menzel","sequence":"additional","affiliation":[{"name":"Hospital Barmherzige Br\u00fcder, Department of Radiology, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Stroszczynski","sequence":"additional","affiliation":[{"name":"Regensburg University Medical Center, Department of Radiology, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Zorger","sequence":"additional","affiliation":[{"name":"Hospital Barmherzige Br\u00fcder, Department of Radiology, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Okka W","family":"Hamer","sequence":"additional","affiliation":[{"name":"Regensburg University Medical Center, Department of Radiology, Regensburg, Germany"},{"name":"Hospital Donaustauf, Department of Radiology, Donaustauf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1473-3099(20)30086-4","article-title":"Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study","volume":"20","author":"H Shi","year":"2020","journal-title":"Lancet Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e200034","DOI":"10.1148\/ryct.2020200034","article-title":"Imaging Profile of the COVID-19 Infection: Radiologic Findings and Literature Review","volume":"2","author":"M Y Ng","year":"2020","journal-title":"Radiol Cardiothorac Imaging"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/RLI.0000000000000672","article-title":"The Clinical and Chest CT Features Associated with Severe and Critical COVID-19 Pneumonia","volume":"55","author":"K Li","year":"2020","journal-title":"Investigative Radiology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"338","DOI":"10.2214\/AJR.20.22961","article-title":"Early Clinical and CT Manifestations of Coronavirus Disease 2019 (COVID-19) Pneumonia","volume":"215","author":"R Han","year":"2020","journal-title":"American Journal of Roentgenology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1148\/radiol.2020200230","article-title":"CT imaging features of 2019 novel coronavirus (2019-NCoV)","volume":"295","author":"M Chung","year":"2020","journal-title":"Radiology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"E79","DOI":"10.1148\/radiol.2020201237","article-title":"Chest CT Features of COVID-19 in\u00a0Rome, Italy","volume":"296","author":"D Caruso","year":"2020","journal-title":"Radiology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1007\/s00330-020-06865-y","article-title":"COVID-19 patients and the radiology 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Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA","volume":"2","author":"S Simpson","year":"2020","journal-title":"Radiol Cardiothorac Imaging"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"E97","DOI":"10.1148\/radiol.2020201473","article-title":"CO-RADS \u2013 A\u00a0categorical CT assessment scheme for patients with suspected COVID-19: definition and evaluation","volume":"296","author":"M Prokop","year":"2020","journal-title":"Radiology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"E145","DOI":"10.1148\/radiol.2020201343","article-title":"Diagnostic Performance of CT and Reverse Transcriptase-Polymerase Chain Reaction for Coronavirus Disease 2019: A Meta-Analysis","volume":"296","author":"H Kim","year":"2020","journal-title":"Radiology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"E115","DOI":"10.1148\/radiol.2020200432","article-title":"Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR","volume":"296","author":"Y Fang","year":"2020","journal-title":"Radiology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"E32","DOI":"10.1148\/radiol.2020200642","article-title":"Correlation of Chest CT and RT-PCR Testing in Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases","volume":"296","author":"T Ai","year":"2020","journal-title":"Radiology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"E46","DOI":"10.1148\/radiol.2020200823","article-title":"Performance of radiologists in differentiating COVID-19 from viral pneumonia on chest CT","volume":"296","author":"H X Bai","year":"2020","journal-title":"Radiology"}],"container-title":["R\u00f6Fo - Fortschritte auf dem Gebiet der R\u00f6ntgenstrahlen und der bildgebenden Verfahren"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1293-9163.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T01:49:25Z","timestamp":1608256165000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1293-9163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,17]]},"references-count":13,"URL":"https:\/\/doi.org\/10.1055\/a-1293-9163","relation":{},"ISSN":["1438-9029","1438-9010"],"issn-type":[{"value":"1438-9029","type":"print"},{"value":"1438-9010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,17]]}}}