{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T10:15:25Z","timestamp":1776507325036,"version":"3.51.2"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Bei Patienten mit Herzinsuffizienz und reduzierter Ejektionsfraktion wird durch eine optimierte medikament\u00f6se Therapie sowohl die Symptomkontrolle verbessert als auch die Mortalit\u00e4t gesenkt. Eckpfeiler der Herzinsuffizienztherapie sind dabei Medikamente mit Einfluss auf das Renin-Angiotensin-Aldosteron-System, sogenannte RAAS-Inhibitoren. Dieser Artikel stellt einen kardiologisch-nephrologischen Konsens zur praxisorientierten Hilfestellung bei abnehmender glomerul\u00e4rer Filtrationsrate oder Anstieg des Serum-Kaliumspiegels vor. Dies sind die 2 h\u00e4ufigsten Gr\u00fcnde f\u00fcr eine Dosisreduktion oder das Absetzen von prognoseverbessernden Medikamenten bei Herzinsuffizienzpatienten.<\/jats:p>","DOI":"10.1055\/a-1307-8652","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T00:25:33Z","timestamp":1611361533000},"page":"e47-e55","source":"Crossref","is-referenced-by-count":1,"title":["Symptomkontrolle bei Herzinsuffizienzpatienten \u2013 was tun bei abfallender GFR und bei Hyperkali\u00e4mie?"],"prefix":"10.1055","volume":"146","author":[{"given":"Vincent","family":"Brandenburg","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie, Nephrologie und Internistische Intensivmedizin, Rhein-Maas-Klinikum, W\u00fcrselen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johann","family":"Bauersachs","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie und Angiologie, Medizinische Hochschule Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Innere Medizin III \u2013 Kardiologie, Angiologie und Internistische Intensivmedizin, Universit\u00e4tsklinikum des\u00a0Saarlandes, Homburg\/Saar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo","family":"Fliser","sequence":"additional","affiliation":[{"name":"Innere Medizin IV \u2013 Nieren- und Hochdruckkrankheiten, Universit\u00e4tsklinikum des Saarlandes, Homburg\/Saar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Frantz","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I (Kardiologie, Endokrinologie, Nephrologie, Pneumologie, Intensiv- und\u00a0Notfallmedizin) Universit\u00e4tsklinikum W\u00fcrzburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Frey","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III (Schwerpunkt Kardiologie, Angiologie und Intensivmedizin), Universit\u00e4tsklinikum Schleswig-Holstein, Kiel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd","family":"Hasenfu\u00df","sequence":"additional","affiliation":[{"name":"Herzzentrum, Abt. 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