{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:09:40Z","timestamp":1767337780254},"reference-count":50,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zentralbl Chir"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Protonenpumpenhemmer werden seit etwa 30 Jahren erfolgreich gegen magens\u00e4ureassoziierte Erkrankungen, wie peptische Ulzera oder Refluxerkrankungen, eingesetzt. Durch ihre kovalente Bindung an die Protonenpumpen in den Parietalzellen des Magens kann die Magens\u00e4ureproduktion effektiv reduziert und die therapeutische Wirkung der Protonenpumpenhemmer entfaltet werden. Auf diese Weise wird aber auch ein wichtiger Bestandteil der unspezifischen Immunabwehr ausgeschaltet, der den K\u00f6rper \u2013 und vor allem das Darmmikrobiom \u2013 vor mit der Nahrung aufgenommenen Pathogenen oder eingeschwemmten Mundkeimen sch\u00fctzt. Daraus ergeben sich Ver\u00e4nderungen des Darmmikrobioms, wie eine Reduktion der Diversit\u00e4t des Mikrobioms oder eine Fehlbesiedelung des D\u00fcnndarms, die mit verschiedenen Nebenwirkungen der Protonenpumpen-(Langzeit-)Therapie, wie einem erh\u00f6hten Risiko f\u00fcr Clostridium-difficile-Infektionen oder gastrointestinalen Beschwerden, assoziiert sind. Bei Menschen mit Leberzirrhose bspw.\n\t\t\t\t\tist die Einwanderung von oralen Bakterien in den Darm mit intestinaler Inflammation und Permeabilit\u00e4t verbunden und kann als Biomarker f\u00fcr das 3-Jahres-\u00dcberleben herangezogen werden. Mikrobiomassoziierte Nebenwirkungen sollten daher in den Diskurs \u00fcber die Risiken von Langzeittherapien mit Protonenpumpenhemmern und dem Abw\u00e4gen von Alternativen miteinbezogen werden.<\/jats:p>","DOI":"10.1055\/a-1312-7587","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:31:41Z","timestamp":1608165101000},"page":"165-169","source":"Crossref","is-referenced-by-count":1,"title":["Das Mikrobiom als Drehscheibe f\u00fcr Nebenwirkungen der Protonenpumpenhemmer-Therapie"],"prefix":"10.1055","volume":"146","author":[{"given":"Angela","family":"Horvath","sequence":"additional","affiliation":[{"name":"Klinische Abteilung f\u00fcr Gastroenterologie und Hepatologie, Medizinische Universit\u00e4t Graz, \u00d6sterreich"},{"name":"Center for Biomarker Research in Medicine, Graz, \u00d6sterreich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Stadlbauer","sequence":"additional","affiliation":[{"name":"Klinische Abteilung f\u00fcr Gastroenterologie und Hepatologie, Medizinische Universit\u00e4t Graz, \u00d6sterreich"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,12,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejim.2016.10.007","article-title":"The appropriate use of proton pump inhibitors (PPIs): Need for a reappraisal","volume":"37","author":"V Savarino","year":"2017","journal-title":"Eur J Intern Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s00228-010-0871-9","article-title":"Appropriateness of treatment recommendations for PPI in hospital discharge letters","volume":"66","author":"D Ahrens","year":"2010","journal-title":"Eur J Clin Pharmacol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/BOR.0000000000000291","article-title":"Proton pump inhibitors and osteoporosis","volume":"28","author":"B N 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