{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T10:16:09Z","timestamp":1648548969580},"reference-count":6,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aktuelle Urol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Instillationstherapie stellt im Feld der urothelialen Neoplasien der Harnblase eine einzigartige Therapiem\u00f6glichkeit dar, die so in keinem anderen medizinischen Bereich zur Anwendung kommt. Mit der Wahl des zu instillierenden Medikamentes hat sich die Forschung der vergangenen Jahre intensiv besch\u00e4ftigt, hierbei hat sich besonders der Einsatz von Bacillus Calmette-Guerin (BCG) und Mitomycin C (MMC) bew\u00e4hrt. Weitere Medikamente, die jedoch seltener zum Einsatz kommen, sind Chemotherapeutika wie Gemcitabin, dessen klinische Relevanz in diesem Artikel beleuchtet werden soll.<\/jats:p><jats:p>So vielf\u00e4ltig, wie die Therapiem\u00f6glichkeiten der Harnblasentumore, ist auch ihre Histopathologie. Das invertierte Papillom stellt im Formenkreis der urologischen Erkrankungen eine seltene Krankheitsentit\u00e4t dar. Eine Assoziation zum nicht-muskelinvasiven Harnblasenkarzinom wird diskutiert.<\/jats:p><jats:p>Wir berichten von dem Fall einer Patientin mit invertiertem Papillom der Harnblase, welche nach Versagen einer BCG-Therapie und einer allergischen Reaktion gegen MMC mit einer Gemcitabin-Instillationstherapie behandelt wurde.<\/jats:p>","DOI":"10.1055\/a-1312-9032","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:06:04Z","timestamp":1612224364000},"page":"43-46","source":"Crossref","is-referenced-by-count":1,"title":["Intravesikale Gemcitabin-Instillationstherapie bei BCG-Versagen und Mitomycin-Allergie \u2013 Der besondere Fall einer Patientin mit invertiertem Papillom der Harnblase"],"prefix":"10.1055","volume":"52","author":[{"given":"Merle","family":"Matzen","sequence":"additional","affiliation":[{"name":"University Hospital Schleswig-Holstein, Campus Luebeck, Department of Urology, Luebeck"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Offermann","sequence":"additional","affiliation":[{"name":"University Hospital Schleswig-Holstein, Campus Luebeck, Institute of Pathology, Luebeck"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Tharun","sequence":"additional","affiliation":[{"name":"University Hospital Schleswig-Holstein, Campus Luebeck, Institute of Pathology, Luebeck"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Perner","sequence":"additional","affiliation":[{"name":"University Hospital Schleswig-Holstein, Campus Luebeck, Institute of Pathology, Luebeck"},{"name":"Research Center Borstel, Leibniz Lung Center, Pathology, Borstel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel S.","family":"Merseburger","sequence":"additional","affiliation":[{"name":"University Hospital Schleswig-Holstein, Campus Luebeck, Department of Urology, Luebeck"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Kramer","sequence":"additional","affiliation":[{"name":"University Hospital Schleswig-Holstein, Campus Luebeck, Department of Urology, Luebeck"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Christine","family":"Hupe","sequence":"additional","affiliation":[{"name":"University Hospital Schleswig-Holstein, Campus Luebeck, Department of Urology, Luebeck"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"ref2","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1097\/01.ju.0000085342.15918.d7","article-title":"Clinical studies on inverted papilloma of the urinary tract: report of 48 cases and review of the literature","volume":"170","author":"K Asano","year":"2003","journal-title":"J Urol"},{"key":"ref3","first-page":"35","article-title":"Prognostic value of inverted papilloma of the lower urinary tract","volume":"54","author":"C Nunez Mora","year":"2001","journal-title":"Arch Esp Urol"},{"key":"ref4","first-page":"14","volume-title":"Oberfl\u00e4chlicher Harnblasentumor \u2013 intravesikale Therapie","author":"M Retz","year":"2010"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1600-0536.1991.tb01699.x","article-title":"Systemic allergic contact dermatitis from intravesical instillation of the antitumor antibiotic mitomycin C","volume":"24","author":"A C De Groot","year":"1991","journal-title":"Contact Dermatitis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1200\/JCO.2008.20.8199","article-title":"Randomized phase III trial on gemcitabine versus mytomicin in recurrent superficial bladder cancer: evaluation of efficacy and tolerance","volume":"28","author":"R Addeo","year":"2010","journal-title":"J Clin 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