{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:41:35Z","timestamp":1789627295955,"version":"build-2803163510"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2002Bleeding after endoscopic submucosal dissection (ESD) is a severe adverse event. Several methods to prevent post-ESD bleeding (PEB) have been introduced; however, they have not been widely used because of technical difficulties. We aimed to investigate whether polysaccharide hemostatic powder (PHP), which is very easy to apply, can prevent early post-ESD bleeding, especially in patients with a high risk of post-ESD bleeding.<\/jats:p><jats:p>\n          Methods\u2002This was a prospective, multicenter, randomized, open-label, controlled trial. Patients with a high risk for post-ESD bleeding were enrolled. Patients with gastric neoplasms in whom the resected specimen size was expected to be &gt;\u200a40\u200amm and those who were regularly taking antithrombotic agents were defined as high risk patients. Patients were randomly assigned to the PHP or control groups. <\/jats:p><jats:p>\n          Results\u2002Between May 2017 and September 2018, 143 patients were enrolled (PHP group, 73; control group, 70). The total post-ESD bleeding rate was 6.3\u200a% (PHP group, 5.5\u200a% vs. control group, 7.1\u200a%; P\u200a=\u200a0.74). There was no bleeding within 7 days after ESD in the PHP group.\u200aContinued antithrombotic use was an independent risk factor for post-ESD bleeding. In subgroup analysis excluding the patients who continued to take antithrombotic agents (n\u200a=\u200a129) during ESD, the rate of post-ESD bleeding tended to be lower in the PHP group than in the control group (0\u200a% vs. 6.3\u200a%; P\u200a=\u200a0.06).<\/jats:p><jats:p>\n          Conclusion\u2002PHP did not demonstrate a significant effect on the prevention of post-ESD bleeding in this study. Further larger scale, randomized controlled trials are needed to confirm this.<\/jats:p>","DOI":"10.1055\/a-1312-9420","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T05:33:46Z","timestamp":1605677626000},"page":"994-1002","source":"Crossref","is-referenced-by-count":23,"title":["Polysaccharide hemostatic powder to prevent bleeding after endoscopic submucosal dissection in high risk patients: a randomized controlled trial"],"prefix":"10.1055","volume":"53","clinical-trial-number":[{"clinical-trial-number":"nct03169569","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Da Hyun","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8806-2163","authenticated-orcid":false,"given":"Hee Seok","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3824-3481","authenticated-orcid":false,"given":"Chan Hyuk","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8018-0010","authenticated-orcid":false,"given":"Jun Chul","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of 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