{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:30:55Z","timestamp":1790818255618,"version":"4.1.0"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aim\u2002Pre-endoscopic use of a preparation with tensioactive and mucolytic agents improved gastric mucosa visualization in Eastern studies. Data on Western population are scanty.<\/jats:p><jats:p>\n          Patients and methods\u2002This prospective, endoscopist-blinded, randomized study enrolled patients who underwent esophagogastroduodenoscopy in a single center. Before endoscopy patients, were randomized to receive or not receive an oral preparation with simethicone and N-acetylcysteine in water. A pretested score (Crema Stomach Cleaning Score [CSCS]) for gastric mucosa cleaning evaluation was used. In detail, the stomach was divided into the antrum, body, and fundus and a score of 1 to 3 was assigned to each part (the higher the score, the better the preparation), and a total value \u2264\u200a5 was considered as insufficient. Time between endoscope insertion and clean achievement (mouth to clean time) or the end of examination (mouth to mouth time) was recorded.<\/jats:p><jats:p>\n          Results\u2002A total of 197 patients were enrolled. The mean overall CSCS value and mucosal cleaning in all parts was better in treated patients than in controls. Prevalence total score\u200a\u2264\u200a5 was significantly lower in patients treated before endoscopy. Need for water flush occurred less frequently in treated patients (P\u200a&lt;\u200a0.0001). The mouth to clean time was lower in the treated than in the control group (2.3\u200a\u00b1\u200a1.6 vs 3.8\u200a\u00b1\u200a1.6 min; P\u200a&lt;\u200a0.001), whereas no significant difference in mouth to mouth time emerged.<\/jats:p><jats:p>\n          Conclusions\u2002Data from this study show that premedication with simethicone and N-acetylcysteine results in significantly better endoscopic visualization of gastric mucosa, and the proposed CSCS could be useful for standardizing this evaluation. <\/jats:p>","DOI":"10.1055\/a-1315-0114","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T23:33:49Z","timestamp":1611617629000},"page":"E190-E194","source":"Crossref","is-referenced-by-count":26,"title":["Premedication with simethicone and N-acetylcysteine for improving mucosal visibility during upper gastrointestinal endoscopy in a Western population"],"prefix":"10.1055","volume":"09","author":[{"given":"Guido","family":"Manfredi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Department, ASST Crema Maggiore Hospital, Crema, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Bert\u00e8","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Department, ASST Crema Maggiore Hospital, Crema, Italy"},{"name":"Gastroenterology and Endoscopy Department, \u2018Ca\u2019 Granda\u2019 Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Iiritano","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Department, ASST Crema Maggiore Hospital, Crema, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Alicante","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Department, ASST Crema Maggiore Hospital, Crema, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Londoni","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Department, ASST Crema Maggiore Hospital, Crema, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Brambilla","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Department, ASST Crema Maggiore Hospital, Crema, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samanta","family":"Romeo","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Department, ASST Crema Maggiore Hospital, Crema, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Menozzi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Department, ASST Crema Maggiore Hospital, Crema, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Griffanti","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Department, ASST Crema Maggiore Hospital, Crema, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Brandi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Department, ASST Crema Maggiore Hospital, Crema, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliva","family":"Moreschi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Department, ASST Crema Maggiore Hospital, Crema, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Pezzilli","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, \u2018San Carlo\u2019 Hospital, Potenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Zullo","sequence":"additional","affiliation":[{"name":"Gastroenterology, \u2018Nuovo Regina Margherita\u2019 Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Buscarini","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Department, ASST Crema Maggiore Hospital, Crema, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,1,25]]},"reference":[{"key":"ref1","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"F Bray","year":"2018","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1136\/gutjnl-2019-320234","article-title":"Is gastric cancer becoming a rare disease? 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