{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T02:00:53Z","timestamp":1770343253666,"version":"3.49.0"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction Until now, venous pressure within the eye has widely been equated with intraocular pressure (IOP). Measurements with dynamometers calibrated in instrument units or in\n\t\t\t\t\tforce showed that the retinal venous pressure (RVP) may be higher than the IOP in glaucoma patients. In this study, the RVP was measured with a contact lens dynamometer calibrated in\n\t\t\t\t\tmmHg.<\/jats:p><jats:p>\n          Methods Study type: cross-sectional. Subjects: Fifty consecutive patients with primary open-angle glaucoma (POAG) who underwent diurnal curve measurement under medication. Age:\n\t\t\t\t\t69\u2009\u00b1\u20098 years. Measurement of RVP: contact lens dynamometry. IOP measurement: dynamic contour tonometry.<\/jats:p><jats:p>\n          Results Pressures are given in mmHg. In all 50 patients, the IOP was 15.9 (13.6; 17.1) [median (Q1; Q3)], and the RVP was 17.4 (14.8; 27.2). The distribution of the IOP was normal\n\t\t\t\t\tand that of the RVP was right skewed. In the subgroup of 34\u00a0patients with spontaneous pulsation of the central retinal vein (SVP), the IOP and therefore, by definition, the RVP was 16.5\n\t\t\t\t\t(13.7; 17.4). In the subgroup of 16 patients without SVP, the IOP was 14.8 (13.3; 16.4), and the RVP was 31.3 (26.2; 38.8) (p\u2009\u2264\u20090.001). In systemic treatment, the prescribed drugs were (the\n\t\t\t\t\tnumber of patients is given in parentheses): ACE inhibitors (20), \u03b2-blockers (17), angiotensin II-receptor blockers (13), calcium channel blockers (12), diuretics (7). No difference\n\t\t\t\t\tin RVP was observed between patients receiving these drugs and not receiving them, except in the \u03b2-blocker group. Here, the 17 patients with systemic \u03b2-blockers had a median\n\t\t\t\t\tRVP of 15.6\u2009mmHg and without 20.2\u2009mmHg (p\u2009=\u20090.003). In the 16 patients with a higher RVP than IOP, only one patient received a systemic \u03b2-blocker. The median IOP was 15.7\u2009mmHg with\n\t\t\t\t\tsystemic \u03b2-blockers and 16.1\u2009mmHg without (p\u2009=\u20090.85).<\/jats:p><jats:p>\n          Conclusion In a subgroup of 16 of the 50 patients studied, the RVP was greater than the IOP by a highly statistically and clinically significant degree. According to the widely\n\t\t\t\t\taccepted thinking on the pathophysiology of retinal and optic nerve head circulation, the blood flow in these tissues may be much more compromised in this group of patients than has been\n\t\t\t\t\tassumed. They may be identified by a missing SVP. Topical and systemic medications showed no statistically significant influence on the RVP, except for the systemic \u03b2-blockers, in\n\t\t\t\t\twhich the RVP was lower by 4.6\u2009mmHg than for the patients who did not receive these drugs (p\u2009=\u20090.003).<\/jats:p>","DOI":"10.1055\/a-1318-9991","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T23:41:39Z","timestamp":1610494899000},"page":"319-325","source":"Crossref","is-referenced-by-count":4,"title":["The Distribution of Retinal Venous Pressure and Intraocular Pressure Differs Significantly in Patients with Primary Open-Angle Glaucoma"],"prefix":"10.1055","volume":"239","author":[{"given":"Richard","family":"Stodtmeister","sequence":"additional","affiliation":[{"name":"Augenklinik, Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"Augenarzt, Augenspezialisten Saar, V\u00f6lklingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiebke","family":"Koch","sequence":"additional","affiliation":[{"name":"Augenklinik, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvana","family":"Georgii","sequence":"additional","affiliation":[{"name":"Augenklinik, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin R.","family":"Pillunat","sequence":"additional","affiliation":[{"name":"Augenkinik, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberhard","family":"Sp\u00f6rl","sequence":"additional","affiliation":[{"name":"Augenklinik, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz E.","family":"Pillunat","sequence":"additional","affiliation":[{"name":"Augenklinik, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1136\/bjo.2010.182527","article-title":"Open-angle glaucoma and ocular perfusion","volume":"94","author":"A G Konstas","year":"2010","journal-title":"Br J Ophthalmol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.coph.2012.09.003","article-title":"Ocular perfusion pressure and ocular blood flow in glaucoma","volume":"13","author":"A P Cherecheanu","year":"2013","journal-title":"Curr Opin Pharmacol"},{"key":"ref3","first-page":"211","volume-title":"Local determinants","author":"J W Kiel","year":"2012"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.ajo.2010.01.018","article-title":"Blood pressure, perfusion pressure, and glaucoma","volume":"149","author":"J 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Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1318-9991.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T14:09:42Z","timestamp":1676038182000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1318-9991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,12]]},"references-count":34,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2022,3,22]]},"published-print":{"date-parts":[[2022,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1318-9991","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"value":"0023-2165","type":"print"},{"value":"1439-3999","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,12]]}}}