{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:48:25Z","timestamp":1788306505362,"version":"build-2803163510"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose\u2002To describe the prenatal ultrasonographic characteristics and perinatal outcomes of congenital cataract.<\/jats:p><jats:p>\n          Materials and Methods\u2002We analyzed congenital cataract diagnosed prenatally at four referral centers between August 2004 and February 2019. The diagnosis was confirmed by postnatal ophthalmologic evaluation of liveborn infants or autopsy for terminated cases. Maternal demographics, genetic testing results, prenatal ultrasound images, and perinatal outcomes were abstracted.<\/jats:p><jats:p>\n          Results\u2002Total of 41 cases of congenital cataract diagnosed prenatally among 788\u200a751 women undergoing anatomic survey. Based on the sonographic characteristics, 16\/41 (39.0\u200a%) had a dense echogenic structure, 15\/41 (36.6\u200a%) had a hyperechogenic spot and 10\/41 (24.4\u200a%) had the \u201cdouble ring\u201d sign. 17\/41 (41.5\u200a%) were isolated, and 24\/41 (58.5\u200a%) had associated intraocular and extraocular findings. Microphthalmia, cardiac abnormalities, and central nervous system abnormalities were the most common associated abnormalities. Regarding potential etiology, 6 cases had a known family history of congenital cataract, 4 cases had confirmed congenital rubella infection, and 2 cases had aneuploidy. 31\/41 (75.6\u200a%) elected termination and 10\/41 (24.4\u200a%) elected to continue their pregnancy. Among the 10 cases, one case died, one case was lost to follow-up, and the remaining 8 cases were referred for ophthalmologist follow-up and postnatal surgery.<\/jats:p><jats:p>\n          Conclusion\u2002Once fetal cataracts are detected, a detailed fetal anatomy survey to rule out associated abnormalities and a workup to identify the potential etiology are recommended. Prenatal diagnosis of congenital cataracts provides vital information for counseling and subsequent management.<\/jats:p>","DOI":"10.1055\/a-1320-0799","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:10:40Z","timestamp":1615939840000},"page":"e125-e134","source":"Crossref","is-referenced-by-count":9,"title":["Prenatal Diagnosis of Congenital Cataract: Sonographic Features and\u00a0Perinatal Outcome in 41 Cases"],"prefix":"10.1055","volume":"43","author":[{"given":"Yue","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Shenzhen Maternity & Child Healthcare Hospital, The First School of Clinical Medicine, Southern Medical University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Xiamen Maternal\uff06Child HealthCare Hospital, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaxuan","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Shenzhen Maternity & Child Healthcare Hospital, The First School of Clinical Medicine, Southern Medical University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Shenzhen Maternity & Child Healthcare Hospital, The First School of Clinical Medicine, Southern Medical University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimei","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Shenzhen Maternity & Child Healthcare Hospital, The First School of Clinical Medicine, Southern Medical University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Shenzhen Maternity & Child Healthcare Hospital, The First School of Clinical Medicine, Southern Medical University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Shenzhen Maternity & Child Healthcare Hospital, The First School of Clinical Medicine, Southern Medical University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Affiliated Hospital of Guizhou Medical University, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaju","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Shenzhen Renai Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongrui","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Cangxian Hospital, Cangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuihua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Maternity & Child Healthcare Hospital of Guangxi Zhuang Autonomous Region, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxian","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Maternity & Child Healthcare Hospital of Guangxi Zhuang Autonomous Region, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Howard University College of Medicine, Washington, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2649-1085","authenticated-orcid":false,"given":"Shengli","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Shenzhen Maternity & Child Healthcare Hospital, The First School of Clinical Medicine, Southern Medical University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"ref1","first-page":"277","article-title":"Advancement of congenital cataract in the responsible gene","volume":"3","author":"L Peng","year":"2010","journal-title":"Int J Ophthalmol"},{"key":"ref2","first-page":"793","article-title":"Mutation analysis of CRYAA, CRYGC, and CRYGD associated with autosomal dominant congenital cataract in Brazilian families","volume":"15","author":"A Santana","year":"2009","journal-title":"Mol Vis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000442495","article-title":"Genetics of Congenital Cataract","volume":"57","author":"F Pichi","year":"2016","journal-title":"Dev Ophthalmol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000238117","article-title":"Prenatal diagnosis of fetal cataract: case report and review of the literature","volume":"26","author":"A L\u00e9onard","year":"2009","journal-title":"Fetal Diagn Ther"},{"key":"ref5","first-page":"443","article-title":"First- and second-trimester diagnosis of fetal ocular defects and associated anomalies: Report of eight cases","volume":"77","author":"M Bronshtein","year":"1991","journal-title":"Obstet Gynecol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.tjog.2015.06.004","article-title":"Congenital cataracts diagnosed by prenatal ultrasound","volume":"54","author":"P F Chen","year":"2015","journal-title":"Taiwan J Obstet Gynecol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.survophthal.2004.02.013","article-title":"Molecular genetic basis of inherited cataract and associated phenotypes","volume":"49","author":"M A Reddy","year":"2004","journal-title":"Surv Ophthalmol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/s-0042-120841","article-title":"Prenatal Ultrasonographic Diagnosis of Cataract: In Utero Manifestations of Cryptic Disease","volume":"39","author":"E Ashwal","year":"2018","journal-title":"Ultraschall in Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/uog.1748","article-title":"Early sonographic detection of recurrent fetal eye anomalies","volume":"24","author":"R Mashiach","year":"2004","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/ajmg.a.30109","article-title":"Congenital cataract, microphthalmia, hypoplasia of corpus callosum and hypogenitalism: report and review of Micro syndrome","volume":"128A","author":"M Derbent","year":"2004","journal-title":"Am J Med Genet A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000264467","article-title":"Second-Trimester Diagnosis of Fetal Cataract in a Fetus with Walker-Warburg Syndrome","volume":"12","author":"E J Beinder","year":"1997","journal-title":"Fetal Diagn Ther"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1016\/S0140-6736(16)31982-1","article-title":"Global prevalence and epidemiological characteristics of congenital cataract: a systematic review and meta-analysis","volume":"388","author":"X Wu","year":"2016","journal-title":"Lancet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/pd.1970130612","article-title":"Sonographic diagnosis of fetal congenital cataracts","volume":"13","author":"E Z Zimmer","year":"1993","journal-title":"Prenat Diagn"},{"key":"ref14","first-page":"2108","article-title":"Congenital and infantile cataract in the United Kingdom: underlying or associated factors. British Congenital Cataract Interest Group","volume":"41","author":"J S Rahi","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1136\/bjo.86.7.782","article-title":"Aetiology of congenital and paediatric cataract in an Australian population","volume":"86","author":"M G Wirth","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.3892\/etm.2016.3348","article-title":"Detection of TORCH pathogens in children with congenital cataracts","volume":"12","author":"B Lu","year":"2016","journal-title":"Exp Ther Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/eye.2016.159","article-title":"Congenital cataract associated with persistent fetal vasculature: findings from IoLunder2","volume":"30","author":"A L Solebo","year":"2016","journal-title":"Eye (Lond)"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1136\/bjo.2006.094656","article-title":"Long term results of primary posterior chamber intraocular lens implantation for congenital cataract in the first year of life","volume":"90","author":"P Gouws","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1091-8531(02)42009-5","article-title":"Complications in infants undergoing surgery for congenital cataract in the first 12 weeks of life: is early surgery better?","volume":"7","author":"P Watts","year":"2003","journal-title":"J AAPOS"},{"key":"ref20","first-page":"620","article-title":"Treatment of congenital cataract","volume":"35","author":"A R Labelle","year":"1961","journal-title":"J Int Coll Surg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00417-012-1979-7","article-title":"Long-term outcome of primary versus secondary intraocular lens implantation after simultaneous removal of bilateral congenital cataract","volume":"251","author":"A Magli","year":"2013","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0002-9394(89)90007-X","article-title":"Complications after surgery for congenital and infantile cataracts","volume":"108","author":"R V Keech","year":"1989","journal-title":"Am J Ophthalmol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"234","DOI":"10.7863\/jum.1993.12.4.234","article-title":"In utero detection of fetal cataracts","volume":"12","author":"E A Gaary","year":"1993","journal-title":"J Ultrasound Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1046\/j.1469-0705.1996.08020104.x","article-title":"Autosomal dominant cataracts of the fetus: early detection by transvaginal ultrasound","volume":"8","author":"A Monteagudo","year":"1996","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1046\/j.1469-0705.1997.09010062.x","article-title":"Prenatal detection of congenital inherited cataracts","volume":"9","author":"K Drysdale","year":"1997","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"385","DOI":"10.5694\/j.1326-5377.1998.tb126810.x","article-title":"Prenatal detection of congenital idiopathic cataracts","volume":"169","author":"I A Burgess","year":"1998","journal-title":"Med J Aust"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000053917","article-title":"Congenital Cataract in Triplet Pregnancy after IVF with Frozen Embryos: Prenatal Diagnosis and Management","volume":"16","author":"B Cengiz","year":"2001","journal-title":"Fetal Diagn Ther"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jaapos.2003.07.001","article-title":"Antenatal ophthalmology","volume":"7","author":"S S Lehman","year":"2003","journal-title":"J AAPOS"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1017\/thg.2013.50","article-title":"Isolated congenital hereditary cataract in a dizygotic twin: prenatal ultrasonographic diagnosis","volume":"16","author":"K A Lee","year":"2013","journal-title":"Twin Res Hum Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/ajmg.a.37685","article-title":"Early detection of bilateral cataracts in utero may represent a manifestation of severe congenital disease","volume":"170","author":"M Trkova","year":"2016","journal-title":"Am J Med Genet A"}],"container-title":["Ultraschall in der Medizin - European Journal of Ultrasound"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1320-0799.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T15:19:10Z","timestamp":1676042350000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1320-0799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,16]]},"references-count":30,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2022,12,5]]},"published-print":{"date-parts":[[2022,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1320-0799","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0172-4614","1438-8782"],"issn-type":[{"value":"0172-4614","type":"print"},{"value":"1438-8782","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,16]]}}}