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Brazilian biodiversity is one of the most extensive in the world and could be an effective source of new chemical entities for drug discovery. Mosquitoes are vectors for the transmission of dengue, Zika, chikungunya, yellow fever, and many other diseases of public health importance. These diseases have a major impact on tropical and subtropical countries, and their incidence has increased dramatically in recent decades, reaching billions of people at risk worldwide. The prevention of these diseases is mainly through vector control, which is becoming more difficult because of the emergence of resistant mosquito populations to the chemical insecticides. Strategies to provide efficient and safe vector control are needed, and secondary metabolites from plant species from the Brazilian biodiversity, especially Cerrado, that are biologically active for mosquito control are herein highlighted. Also, this is a literature revision of targets as insights to promote advances in the task of developing active compounds for vector control. In view of the expansion and occurrence of arboviruses diseases worldwide, scientific reviews on bioactive natural products are important to provide molecular models for vector control and contribute with effective measures to reduce their incidence.<\/jats:p>","DOI":"10.1055\/a-1320-4610","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:04:37Z","timestamp":1608595477000},"page":"6-23","source":"Crossref","is-referenced-by-count":10,"title":["The Potential of Biologically Active Brazilian Plant Species as a Strategy to Search for Molecular Models for Mosquito Control"],"prefix":"10.1055","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1106-183X","authenticated-orcid":false,"given":"Marilia","family":"Valli","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal and Computational Chemistry (LQMC), Centre for Research and Innovation in Biodiversity and Drug Discovery (CIBFar), Institute of Physics of S\u00e3o Carlos, University of S\u00e3o Paulo (USP), S\u00e3o Carlos, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6212-8216","authenticated-orcid":false,"given":"Let\u00edcia Cristina Vieira","family":"Atan\u00e1zio","sequence":"additional","affiliation":[{"name":"Nuclei of Bioassays, Biosynthesis and Ecophysiology of Natural Products (NuBBE), Department of Organic Chemistry, Institute of Chemistry, S\u00e3o Paulo State University (UNESP), Araraquara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3011-3028","authenticated-orcid":false,"given":"Gustavo Claro","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacognosia, Universidade de Bras\u00edlia, Campus Universit\u00e1rio Darcy Ribeiro, Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5733-1981","authenticated-orcid":false,"given":"Roberta Ramos","family":"Coelho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacognosia, Universidade de Bras\u00edlia, Campus Universit\u00e1rio Darcy Ribeiro, Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3576-5148","authenticated-orcid":false,"given":"Daniel Pecoraro","family":"Demarque","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacognosia, Universidade de Bras\u00edlia, Campus Universit\u00e1rio Darcy Ribeiro, Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0457-818X","authenticated-orcid":false,"given":"Adriano Defini","family":"Andricopulo","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal and Computational Chemistry (LQMC), Centre for Research and Innovation in Biodiversity and Drug Discovery (CIBFar), Institute of Physics of S\u00e3o Carlos, University of S\u00e3o Paulo (USP), S\u00e3o Carlos, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1886-868X","authenticated-orcid":false,"given":"Laila Salmen","family":"Espindola","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacognosia, Universidade de Bras\u00edlia, Campus Universit\u00e1rio Darcy Ribeiro, Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7019-5825","authenticated-orcid":false,"given":"Vanderlan da Silva","family":"Bolzani","sequence":"additional","affiliation":[{"name":"Nuclei of Bioassays, Biosynthesis and Ecophysiology of Natural Products (NuBBE), Department of Organic Chemistry, Institute of Chemistry, S\u00e3o Paulo State University (UNESP), Araraquara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,12,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"D J Newman","year":"2020","journal-title":"J Nat Prod"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1021\/acs.jcim.8b00619","article-title":"Chemical space and diversity of the NuBBE database: A chemoinformatic characterization","volume":"59","author":"F I Saldivar-Gonzalez","year":"2019","journal-title":"J Chem Inf Model"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/35002501","article-title":"Biodiversity hotspots for conservation priorities","volume":"403","author":"N 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