{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T08:10:36Z","timestamp":1749024636450},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"08","funder":[{"name":"National Research Foundation of Korea (NRF) grants funded by the Korea government","award":["NRF-2017R1D1A1B03036116 (W.J.C.)"],"award-info":[{"award-number":["NRF-2017R1D1A1B03036116 (W.J.C.)"]}]},{"name":"National Research Foundation of Korea (NRF) grants funded by the Korea government","award":["NRF-2018R1A5A2023127 (Y.H.C.)"],"award-info":[{"award-number":["NRF-2018R1A5A2023127 (Y.H.C.)"]}]},{"name":"National Research Foundation of Korea (NRF) grants funded by the Korea government","award":["NRF-2019R1A2C2009053 (Y.-W.C.)"],"award-info":[{"award-number":["NRF-2019R1A2C2009053 (Y.-W.C.)"]}]},{"name":"National Research Foundation of Korea (NRF) grants funded by the Korea government","award":["NRF\u20102016R1C1B2010849 (Y.H.C.)"],"award-info":[{"award-number":["NRF\u20102016R1C1B2010849 (Y.H.C.)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Moracin C from Morus alba fruits, also known as the mulberry, has been proven to exhibit inhibitory activities against lipoxygenase enzymes, TNF-\u03b1 and interleukin-1\u03b2 secretion, and proprotein convertase subtilisin\/kexin type 9 expression. Despite the various pharmacological activities of moracin C, its pharmacokinetic characteristics have yet to be reported. Here, the pharmacokinetic parameters and tissue distribution of moracin C have been investigated in mice, and the plasma concentration of moracin C with multiple dosage regimens was simulated via pharmacokinetic modeling. Our results showed that moracin C was rapidly and well absorbed in the intestinal tract, and was highly distributed in the gastrointestinal tract, liver, kidneys, and lungs. Moracin C was distributed in the ileum, cecum, colon, and liver at a relatively high concentration compared with its plasma concentration. It was extensively metabolized in the liver and intestine, and its\n\t\t\t\t\tglucuronidated metabolites were proposed. In addition, the simulated plasma concentrations of moracin C upon multiple treatments (i.e., every 12 and 24\u2009h) were suggested. We suggest that the pharmacokinetic characteristics of moracin C would be helpful to select a disease model for in vivo evaluation. The simulated moracin C concentrations under various dosage regimens also provide helpful knowledge to support its pharmacological effect.<\/jats:p>","DOI":"10.1055\/a-1321-1519","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T23:34:35Z","timestamp":1611704075000},"page":"642-651","source":"Crossref","is-referenced-by-count":7,"title":["Pharmacokinetic Properties of Moracin C in Mice"],"prefix":"10.1055","volume":"87","author":[{"given":"Byoung Hoon","family":"You","sequence":"first","affiliation":[{"name":"College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Gyeonggi-do, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanayakanakatte Kuberappa","family":"BasavanaGowda","sequence":"first","affiliation":[{"name":"College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Gyeonggi-do, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Un","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Gyeonggi-do, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Won","family":"Chin","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Jun","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Gyeonggi-do, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Hee","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Gyeonggi-do, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,1,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"10383","DOI":"10.1021\/acs.jafc.7b03614","article-title":"The mulberry (Morus alba L.) fruit \u2013 A review of characteristic components and health benefits","volume":"65","author":"Q Yuan","year":"2017","journal-title":"J Agri Food Chem"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1016\/j.fct.2010.05.074","article-title":"Hypolipidemic and antioxidant effect of mulberry (Morus alba L.) fruit in hyperlipidemia rats","volume":"48","author":"X Yang","year":"2010","journal-title":"Food Chem Toxicol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.carbpol.2016.03.043","article-title":"Structural analysis and anti-obesity effect of a pectic polysaccharide 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