{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T17:47:24Z","timestamp":1780595244559,"version":"3.54.1"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myrcia bella is a medicinal plant used for the treatment of diabetes, hemorrhages, and hypertension in Brazilian folk medicine. Considering that plant extracts are attractive sources of new drugs, the aim of the present study was to verify the influence of incorporating 70% hydroalcoholic of M.\u00a0bella leaves in nanostructured lipid systems on the mutagenic and antifungal activities of the extract. In this work, we evaluated the antifungal potential of M.\u00a0bella loaded on the microemulsion against Candida sp for minimum inhibitory concentration, using the microdilution technique. The system was composed of polyoxyethylene 20 cetyl ether and soybean phosphatidylcholine (10%), grape seed oil, cholesterol (10%: proportion 5\/1), and purified water (80%). To investigate the mutagenic activity, the Ames test was used with the Salmonella Typhimurium tester strains. M.\u00a0bella, either incorporated or free, showed an important antifungal effect against all tested strains. Moreover, the incorporation surprisingly inhibited the mutagenicity presented by the extract. The present study attests the antimicrobial properties of M.\u00a0bella extract, contributing to the search for new natural products with biological activities and suggesting caution in its use for medicinal purposes. In addition, the results emphasize the importance of the use of nanotechnology associated with natural products as a strategy for the control of infections caused mainly by the genus Candida sp.<\/jats:p>","DOI":"10.1055\/a-1323-3622","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T06:30:31Z","timestamp":1611901831000},"page":"405-415","source":"Crossref","is-referenced-by-count":9,"title":["Hydroalcoholic Extract of Myrcia bella Loaded into a Microemulsion System: A Study of Antifungal and Mutagenic Potential"],"prefix":"10.1055","volume":"88","author":[{"given":"Gabriel Davi","family":"Marena","sequence":"additional","affiliation":[{"name":"University of Araraquara (UNIARA), Department of Biological Sciences and Health, Araraquara, S\u00e3o Paulo State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza","family":"Girotto","sequence":"additional","affiliation":[{"name":"University of Araraquara (UNIARA), Department of Biological Sciences and Health, Araraquara, S\u00e3o Paulo State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Leonardo","family":"Saldanha","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), Department of Biological Sciences, Faculty of Science, Bauru, S\u00e3o Paulo State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Aparecido dos Santos","family":"Ramos","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), Department of Biological Sciences, School of Pharmaceutical Sciences, Campus Araraquara, S\u00e3o Paulo State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rone Aparecido","family":"De Grandis","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), Department of Biological Sciences, School of Pharmaceutical Sciences, Campus Araraquara, S\u00e3o Paulo State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Bento","family":"da Silva","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), Department of Drugs and Medicines, School of Pharmaceutical Sciences, Campus Araraquara, S\u00e3o Paulo State, Brazil"},{"name":"University of Brasilia, Nanobiotechnology Laboratory, Institute of Biological Sciences, Department of Genetics and Morphology, Bras\u00edlia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne L\u00edgia","family":"Dokkedal","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), Department of Biological Sciences, Faculty of Science, Bauru, S\u00e3o Paulo State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlus","family":"Chorilli","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), Department of Drugs and Medicines, School of Pharmaceutical Sciences, Campus Araraquara, S\u00e3o Paulo State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tais Maria","family":"Bauab","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), Department of Biological Sciences, School of Pharmaceutical Sciences, Campus Araraquara, S\u00e3o Paulo State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Rog\u00e9rio","family":"Pavan","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), Department of Biological Sciences, School of Pharmaceutical Sciences, Campus Araraquara, S\u00e3o Paulo State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane","family":"Trovatti","sequence":"additional","affiliation":[{"name":"University of Araraquara (UNIARA), Department of Biological Sciences and Health, Araraquara, S\u00e3o Paulo State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilton Rog\u00e9rio","family":"Lustri","sequence":"additional","affiliation":[{"name":"University of Araraquara (UNIARA), Department of Biological Sciences and Health, Araraquara, S\u00e3o Paulo State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9432-5919","authenticated-orcid":false,"given":"Fl\u00e1via Ap.","family":"Resende","sequence":"additional","affiliation":[{"name":"University of Araraquara (UNIARA), Department of Biological Sciences and Health, Araraquara, S\u00e3o Paulo State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1126\/science.aap7999","article-title":"Worldwide emergence of resistance to antifungal drugs challenges human health and food security","volume":"360","author":"M C 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