{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:45:17Z","timestamp":1788345917109,"version":"build-2803163510"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"German Conn\u2019s Registry-Else-Kr\u00f6ner Hyperaldosteronism Registry","award":["2013_A182"],"award-info":[{"award-number":["2013_A182"]}]},{"name":"German Conn\u2019s Registry-Else-Kr\u00f6ner Hyperaldosteronism Registry","award":["2015_A171"],"award-info":[{"award-number":["2015_A171"]}]},{"name":"German Conn\u2019s Registry-Else-Kr\u00f6ner Hyperaldosteronism Registry","award":["2019_A104"],"award-info":[{"award-number":["2019_A104"]}]},{"name":"European Research Council (ERC) under the European Union\u2019s Horizon 2020 research and innovation programme","award":["694913"],"award-info":[{"award-number":["694913"]}]},{"name":"Central Relay in Health and Disease"},{"name":"Clinician Scientist PRogram In Vascular MEdicine\n                    (PRIME","award":["MA 2186\/14\u20131 to HS"],"award-info":[{"award-number":["MA 2186\/14\u20131 to HS"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with primary aldosteronism (PA) are at increased cardiovascular\n                        risk, compared to patients with essential hypertension (EH). Cardiovascular\n                        damage could depend on PA phenotype, potentially being lower in milder forms\n                        of PA. Our aim was to assess atherosclerotic burden and arterial stiffness\n                        in 88 prospectively recruited patients, including 44 patients with mild PA\n                        and EH respectively. All patients underwent a structured study program,\n                        including measurements of ankle-brachial index, oscillometric measurement of\n                        central pulse wave velocity (cPWV) and vascular ultrasound examination of\n                        the supraaortic arteries, the abdominal aorta, and the femoropopliteal\n                        arteries. A plaque score was calculated to estimate atherosclerotic burden\n                        for each patient. This is a prospective case-control study set at a tertiary\n                        care hospital. Patients with PA and EH matched well for age, gender, blood\n                        pressure, BMI, and cardiovascular risk factors such as diabetes mellitus and\n                        smoking status. Common carotid intima-media thickness (0.77 vs.\n                        0.75\u2009mm; p=0.997) and cPWV (7.2 vs. 7.1\u2009m\/s;\n                        p=0.372) were comparable between patients with PA and EH. The\n                        atherosclerotic burden, as expressed by the plaque score, did not differ\n                        between the two groups (p=0.159). However, after initiation of\n                        treatment cPWV was significantly decreased in patients with PA\n                        (p=0.017). This study shows that subclinical atherosclerotic burden\n                        and arterial stiffness in patients with milder forms of PA is comparable to\n                        patients with EH. Nevertheless, specific treatment for PA significantly\n                        improved cPWV, which argues for a more liberal use of mineralocorticoid\n                        receptor antagonists in patients with arterial hypertension.<\/jats:p>","DOI":"10.1055\/a-1326-2164","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T23:43:15Z","timestamp":1610581395000},"page":"178-184","source":"Crossref","is-referenced-by-count":9,"title":["Atherosclerotic Burden and Arterial Stiffness are Not Increased in\n                    Patients with Milder Forms of Primary Aldosteronism Compared to Patients with\n                    Essential Hypertension"],"prefix":"10.1055","volume":"53","author":[{"given":"Christian","family":"Lottspeich","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU M\u00fcnchen, Munich,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU M\u00fcnchen, Munich,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Czihal","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU M\u00fcnchen, Munich,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU M\u00fcnchen, Munich,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1556-0951","authenticated-orcid":false,"given":"Holger","family":"Schneider","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU M\u00fcnchen, Munich,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Handgriff","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU M\u00fcnchen, Munich,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU M\u00fcnchen, Munich,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Adolf","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU M\u00fcnchen, Munich,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,1,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.jacc.2017.01.052","article-title":"Prevalence and clinical manifestations of primary aldosteronism encountered in\n                    primary care practice","volume":"69","author":"S Monticone","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.jacc.2006.07.059","article-title":"A prospective study of the prevalence of primary aldosteronism in 1125\n                    hypertensive patients","volume":"48","author":"G P Rossi","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"ref3","first-page":"100","article-title":"Normokali\u00e4mischer prim\u00e4rer Hyperaldosteronismus","author":"M Reincke","year":"2003","journal-title":"Dtsch Arztebl"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1530\/EJE-17-0978","article-title":"Primary aldosteronism: key characteristics at diagnosis: a trend toward milder\n                    forms","volume":"178","author":"D A Heinrich","year":"2018","journal-title":"Eur J Endocrinol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S2213-8587(17)30319-4","article-title":"Cardiovascular events and target organ damage in primary aldosteronism compared\n                    with essential hypertension: a systematic review and meta-analysis","volume":"6","author":"S Monticone","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.jacc.2005.01.015","article-title":"Evidence for an increased rate of cardiovascular events in patients with primary\n                    aldosteronism","volume":"45","author":"P Milliez","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"H1802","DOI":"10.1152\/ajpheart.01096.2001","article-title":"Aldosterone induces a vascular inflammatory phenotype in the rat heart","volume":"283","author":"R Rocha","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref8","first-page":"893","article-title":"Mineralocorticoid excess, dietary sodium, and myocardial fibrosis","volume":"120","author":"C G Brilla","year":"1992","journal-title":"J Lab Clin Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1172\/JCI117269","article-title":"Mineralocorticoids, hypertension, and cardiac fibrosis","volume":"93","author":"M Young","year":"1994","journal-title":"J Clin Invest"},{"key":"ref10","first-page":"20","article-title":"Endothelial dysfunction in primary aldosteronism","author":"Z W Chen","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ijcard.2016.01.200","article-title":"Cardiovascular risk markers in patients with primary aldosteronism: A systematic\n                    review and meta-analysis of literature studies","volume":"208","author":"P Ambrosino","year":"2016","journal-title":"Int J Cardiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1097\/HJH.0b013e32831286fd","article-title":"Arterial stiffness, intima-media thickness and carotid artery fibrosis in\n                    patients with primary aldosteronism","volume":"26","author":"G Bernini","year":"2008","journal-title":"J Hypertens"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.atherosclerosis.2011.12.003","article-title":"Adrenalectomy improves increased carotid intima-media thickness and arterial\n                    stiffness in patients with aldosterone producing adenoma","volume":"221","author":"Y H Lin","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1097\/HJH.0b013e3281268532","article-title":"Increased intima-media thickness of the common carotid artery in primary\n                    aldosteronism in comparison with essential hypertension","volume":"25","author":"R Holaj","year":"2007","journal-title":"J Hypertens"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1097\/HJH.0000000000000464","article-title":"Long-term effect of specific treatment of primary aldosteronism on carotid\n                    intima-media thickness","volume":"33","author":"R Holaj","year":"2015","journal-title":"J Hypertens"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"461","DOI":"10.33549\/physiolres.932344","article-title":"Peripheral arterial stiffness in primary aldosteronism","volume":"61","author":"J Rosa","year":"2012","journal-title":"Physiol Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/clc.20270","article-title":"Myocardial and aortic stiffening in the early course of primary\n                    aldosteronism","volume":"31","author":"C Tsioufis","year":"2008","journal-title":"Clin Cardiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1097\/HJH.0000000000001251","article-title":"Plasma aldosterone level within the normal range is less associated with\n                    cardiovascular and cerebrovascular risk in primary aldosteronism","volume":"35","author":"M Murata","year":"2017","journal-title":"J Hypertens"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1210\/jc.2018-00617","article-title":"Cortisol excess in patients with primary aldosteronism impacts left ventricular\n                    hypertrophy","volume":"103","author":"C Adolf","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: Case detection, diagnosis, and\n                    treatment: An Endocrine Society Clinical Practice Guideline","volume":"101","author":"J W Funder","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1530\/EJE-11-0287","article-title":"Adrenal vein sampling using rapid cortisol assays in primary aldosteronism is\n                    useful in centers with low success rates","volume":"165","author":"M J Betz","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1161\/CIR.0b013e318276fbcb","article-title":"Measurement and interpretation of the ankle-brachial index: a scientific\n                    statement from the American Heart Association","volume":"126","author":"V Aboyans","year":"2012","journal-title":"Circulation"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.ATV.0000133194.94939.42","article-title":"Vascular calcification: mechanisms and clinical ramifications","volume":"24","author":"M Abedin","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000371355","article-title":"Underdiagnosis of obstructive sleep apnoea in peripheral arterial disease","author":"C Pizarro","year":"2015","journal-title":"Respiration"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1024\/0301-1526\/a000858","article-title":"Aortic stiffness and related complications after endovascular repair of blunt\n                    thoracic aortic injury in young patients","volume":"49","author":"A Youssef","year":"2020","journal-title":"Vasa"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1159\/000081812","article-title":"Mannheim intima-media thickness consensus","volume":"18","author":"P J Touboul","year":"2004","journal-title":"Cerebrovasc Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/1358863X08101542","article-title":"Carotid and femoral arterial wall changes and the prevalence of clinical\n                    cardiovascular disease","volume":"14","author":"M Griffin","year":"2009","journal-title":"Vasc Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/bjs.9463","article-title":"Comparison of three ultrasound methods of measuring the diameter of the\n                    abdominal aorta","volume":"101","author":"M Gurtelschmid","year":"2014","journal-title":"Br J Surg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10554-004-8165-x","article-title":"Intima-media thickness score from carotid and femoral arteries predicts the\n                    extent of coronary artery disease: intima-media thickness and CAD","volume":"21","author":"J P Lekakis","year":"2005","journal-title":"Int J Cardiovasc Imaging"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1507\/endocrj.EJ15-0362","article-title":"Eplerenone improves carotid intima-media thickness (IMT) in patients with\n                    primary aldosteronism","volume":"63","author":"Y Matsuda","year":"2016","journal-title":"Endocr J"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s12020-016-0983-9","article-title":"Worsening of lipid metabolism after successful treatment of primary\n                    aldosteronism","volume":"54","author":"C Adolf","year":"2016","journal-title":"Endocrine"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/jch.12986","article-title":"Low dose-eplerenone treatment decreases aortic stiffness in patients with\n                    resistant hypertension","volume":"19","author":"T Kalizki","year":"2017","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/S2213-8587(14)70194-9","article-title":"Anti-albuminuric effect of the aldosterone blocker eplerenone in non-diabetic\n                    hypertensive patients with albuminuria: a double-blind, randomised,\n                    placebo-controlled trial","volume":"2","author":"K Ando","year":"2014","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/ajh.2011.113","article-title":"Inflammation and hypertension: the interplay of interleukin-6, dietary sodium,\n                    and the renin-angiotensin system in humans","volume":"24","author":"B Chamarthi","year":"2011","journal-title":"Am J Hypertens"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s12020-017-1348-8","article-title":"Associations of aldosterone and renin concentrations with inflammation-the Study\n                    of Health in Pomerania and the German Conn\u2019s Registry","volume":"57","author":"A Grotevendt","year":"2017","journal-title":"Endocrine"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s12872-016-0346-8","article-title":"Association between renin and atherosclerotic burden in subjects with and\n                    without type 2 diabetes","volume":"16","author":"I Goncalves","year":"2016","journal-title":"BMC Cardiovasc Disord"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S1357-2725(02)00271-6","article-title":"Inflammation and angiotensin II","volume":"35","author":"Y Suzuki","year":"2003","journal-title":"Int J Biochem Cell Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.atherosclerosis.2011.06.044","article-title":"Carotid plaque, compared with carotid intima-media thickness, more accurately\n                    predicts coronary artery disease events: a meta-analysis","volume":"220","author":"Y Inaba","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.jacc.2015.12.056","article-title":"Femoral and carotid subclinical atherosclerosis association with risk factors\n                    and coronary calcium: The AWHS Study","volume":"67","author":"M Laclaustra","year":"2016","journal-title":"J Am Coll Cardiol"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1326-2164.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T23:35:05Z","timestamp":1614728105000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1326-2164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,13]]},"references-count":39,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2021,3,2]]},"published-print":{"date-parts":[[2021,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1326-2164","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,13]]}}}