{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:07:37Z","timestamp":1790636857094,"version":"4.1.0"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"DOI":"10.13039\/100010129","name":"Maud Kuistilan Muistos\u00e4\u00e4ti\u00f6","doi-asserted-by":"crossref","award":["2019-0366F"],"award-info":[{"award-number":["2019-0366F"]}],"id":[{"id":"10.13039\/100010129","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"crossref","award":["1862\/2018"],"award-info":[{"award-number":["1862\/2018"]}],"id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Difficult biliary cannulation in endoscopic retrograde cholangiopancreatography (ERCP) increases the risk of post-ERCP pancreatitis (PEP). The purpose of this prospective, randomized, multicenter study was to compare two advanced rescue methods, transpancreatic biliary sphincterotomy (TPBS) and a double-guidewire (DGW) technique, in difficult common bile duct (CBD) cannulation. <\/jats:p><jats:p>\n          Methods Patients with native papilla and planned CBD cannulation were recruited at eight Scandinavian hospitals. An experienced endoscopist attempted CBD cannulation with wire-guided cannulation. If the procedure fulfilled the definition of difficult cannulation and a guidewire entered the pancreatic duct, randomization to either TPBS or to DGW was performed. If the randomized method failed, any method available was performed. The primary end point was the frequency of PEP and the secondary end points included successful cannulation with the randomized method.<\/jats:p><jats:p>\n          Results In total, 1190 patients were recruited and 203 (17.1\u200a%) were randomized according to the study protocol (TPBS 104 and DGW 99). PEP developed in 14\/104 patients (13.5\u200a%) in the TPBS group and 16\/99 patients (16.2\u200a%) in the DGW group (P\u200a=\u200a0.69). No difference existed in PEP severity between the groups. The rate of successful deep biliary cannulation was significantly higher with TPBS (84.6\u200a% [88\/104]) than with DGW (69.7\u200a% [69\/99]; P\u200a=\u200a0.01). <\/jats:p><jats:p>\n          Conclusions In difficult biliary cannulation, there was no difference in PEP rate between TPBS and DGW techniques. TPBS is a good alternative in cases of difficult cannulation when the guidewire is in the pancreatic duct.<\/jats:p>","DOI":"10.1055\/a-1327-2025","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T23:46:22Z","timestamp":1610581582000},"page":"1011-1019","source":"Crossref","is-referenced-by-count":35,"title":["Transpancreatic biliary sphincterotomy versus double guidewire in difficult biliary cannulation: a randomized controlled trial"],"prefix":"10.1055","volume":"53","clinical-trial-number":[{"clinical-trial-number":"nct02548884","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Leena","family":"Kyl\u00e4np\u00e4\u00e4","sequence":"additional","affiliation":[{"name":"Abdominal Center, Gastroenterological Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6869-0752","authenticated-orcid":false,"given":"Vilja","family":"Koskensalo","sequence":"additional","affiliation":[{"name":"Abdominal Center, Gastroenterological Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arto","family":"Saarela","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Oulu University Hospital, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Ejstrud","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Aalborg University Hospital, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Udd","sequence":"additional","affiliation":[{"name":"Abdominal Center, Gastroenterological Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Outi","family":"Lindstr\u00f6m","sequence":"additional","affiliation":[{"name":"Abdominal Center, Gastroenterological Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Rainio","sequence":"additional","affiliation":[{"name":"Abdominal Center, Gastroenterological Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Tenca","sequence":"additional","affiliation":[{"name":"Abdominal Center, Gastroenterology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorma","family":"Halttunen","sequence":"additional","affiliation":[{"name":"Abdominal Center, Gastroenterological Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Qvigstad","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urban","family":"Arnelo","sequence":"additional","affiliation":[{"name":"Department of Upper Gastrointestinal Diseases, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Fagerstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Upper Gastrointestinal Diseases, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Truls","family":"Hauge","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Aabakken","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, Rikshospitalet University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Gr\u00f6nroos","sequence":"additional","affiliation":[{"name":"Division of Digestive Surgery and Urology, Turku University Hospital and University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,1,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1055\/s-0042-108641","article-title":"Papillary cannulation and sphincterotomy techniques at ERCP: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline","volume":"48","author":"P A 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cannulation: a prospective multicenter study by the Scandinavian Association for Digestive Endoscopy Study Group for ERCP","volume":"90","author":"E Haraldsson","year":"2019","journal-title":"Gastrointest Endosc"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1007\/s10620-019-05640-4","article-title":"Transpancreatic sphincterotomy is effective and safe in expert hands on the short term","volume":"64","author":"D P\u00e9csi","year":"2019","journal-title":"Dig Dis Sci"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-019-07364-y","article-title":"Transpancreatic biliary sphincterotomy for biliary access is safe also on a long-term scale","author":"V Koskensalo","year":"2020","journal-title":"Surg 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