{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:10Z","timestamp":1740126850702,"version":"3.37.3"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Intraocular epithelial downgrowth is a rare but potentially devastating posttraumatic complication. If left untreated, this may result in corneal decompensation, secondary\n\t\t\t\t\tangle-closure glaucoma, retinal detachment and blindness.<\/jats:p><jats:p>\n          Patient and Method A 10-year-old patient with penetrating globe injury and delayed wound management elsewhere presented with corneal melting and decompensation, retinal detachment\n\t\t\t\t\tand ocular hypotony. Following penetrating keratoplasty, cyclopexy and vitrectomy, corneal melting in the interface with renewed retinal detachment was noted within days. The hopeless\n\t\t\t\t\tprognosis required enucleation of the globe.<\/jats:p><jats:p>\n          Results Optical coherence tomography revealed not only corneal melting, but also markedly hyperreflective structures posterior to the cornea. Immunohistology demonstrated diffuse\n\t\t\t\t\tmulti-layered nonkeratinised squamous cell epithelium on the posterior corneal surface, iris, ciliary bodies, and retina, as well as below the choroid, with renewed tractional retinal\n\t\t\t\t\tdetachment.<\/jats:p><jats:p>\n          Conclusion Posttraumatic epithelial downgrowth may result in tractional retinal detachment, cyclodialysis cleft and\/or corneal melting. Hyperreflective membrane deposits on OCT may\n\t\t\t\t\tbe indicative of diffuse epithelial downgrowth. Especially in children, prompt wound closure in globe injuries is vital to avoid this serious posttraumatic complication.<\/jats:p>","DOI":"10.1055\/a-1332-1734","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T23:54:05Z","timestamp":1612482845000},"page":"191-195","source":"Crossref","is-referenced-by-count":1,"title":["Posttraumatic Ocular Hypotony Through Epithelial Downgrowth"],"prefix":"10.1055","volume":"239","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0384-0622","authenticated-orcid":false,"given":"Joana","family":"Heinzelmann","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik und Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Halle, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celestina","family":"Schober","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik und Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Halle, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Huth","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik und Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Halle, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udo","family":"Siebolts","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie, Martin-Luther-Universit\u00e4t Halle-Wittenberg, Halle, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Viestenz","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik und Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Halle, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1016\/S0161-6420(02)01274-5","article-title":"Epithelial downgrowth after clear cornea phacoemulsification: report of two cases and review of the literature","volume":"109","author":"L G Vargas","year":"2002","journal-title":"Ophthalmology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/ca.22937","article-title":"Epithelial invasion after open globe injury","volume":"31","author":"A Viestenz","year":"2018","journal-title":"Clin Anat"},{"key":"ref3","first-page":"603","volume-title":"Chirurgie der Iris und des Ziliark\u00f6rpers","author":"G Mackensen","year":"1988"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"bcr2013009113","DOI":"10.1136\/bcr-2013-009113","article-title":"Growth of corneal epithelial cells over in situ therapeutic contact lens after simple limbal epithelial transplantation (SLET)","volume":"2013","author":"S Bhalekar","year":"2013","journal-title":"BMJ Case Rep"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.15761\/CCSR.1000143","article-title":"Penetrating excimer Laser-assisted keratoplasty for corneal epithelial downgrowth in Childhood","author":"B Majkutova","year":"2020","journal-title":"Clin Case Studie Rep"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1055\/s-2002-23498","article-title":"Umwandlung der zystischen in eine diffuse Epithelinvasion durch Laser-Zystener\u00f6ffnung. Bericht \u00fcber 4 Patienten","volume":"219","author":"M JM Groh","year":"2002","journal-title":"Klin Monbl Augenheilkd"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/S0002-9394(14)78104-8","article-title":"Surgical Management of Epithelial Ingrowth","volume":"85","author":"W J Stark","year":"1978","journal-title":"Am J Ophthalmol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.eye.6701481","article-title":"Block-excision of cystic epithelial downgrowth as the treatment of choice","volume":"19","author":"A Viestenz","year":"2005","journal-title":"Eye (Lond)"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1055\/s-2003-40942","article-title":"Blockexzision der Epithelinvasion nach Kataraktoperation \u2013 Bericht \u00fcber 15 Patienten","volume":"220","author":"A Viestenz","year":"2003","journal-title":"Klin Monbl Augenheilkd"},{"key":"ref10","first-page":"448","article-title":"Blockexzision intraokularer Prozesse. II. Epitheleinwachsungen in das vordere Augensegment","volume":"166","author":"G Naumann","year":"1975","journal-title":"Klin Monbl Augenheilkd"},{"key":"ref11","first-page":"325485","article-title":"Epithelial Downgrowth after Intraocular Surgery Treated with Intracameral 5-Fluorouracil","volume":"2015","author":"N Ni","year":"2015","journal-title":"Case Rep Ophthalmol Med"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1332-1734.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T03:12:27Z","timestamp":1645758747000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1332-1734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,4]]},"references-count":11,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2022,2,24]]},"published-print":{"date-parts":[[2022,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1332-1734","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"type":"print","value":"0023-2165"},{"type":"electronic","value":"1439-3999"}],"subject":[],"published":{"date-parts":[[2021,2,4]]}}}