{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T21:59:43Z","timestamp":1781128783318,"version":"3.54.1"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2002Peroral endoscopic myotomy (POEM) is an established treatment for achalasia cardia; however, post-POEM gastroesophageal reflux (GER) remains a significant problem. Concomitant endoscopic fundoplication following POEM (POEM\u200a+\u200aF) was recently described to reduce post-POEM GER. This single-center study reports short-term outcomes of POEM\u200a+\u200aF.<\/jats:p><jats:p>\n          Methods\u2002This was a retrospective analysis of a prospectively maintained database of patients undergoing POEM\u200a+\u200aF. Abstracted data included demographics, achalasia type, pre-POEM Eckardt score, prior therapy, follow-up.\u200aFollow-up assessment was 3-monthly for 1 year and included post-POEM Eckardt score, GerdQ score, wrap integrity and esophagitis on esophagogastroduodenoscopy, and pH studies. GER was defined according to Lyon Consensus.<\/jats:p><jats:p>\n          Results\u200225 patients underwent POEM\u200a+\u200aF (mean age 40.1 years [standard deviation (SD) 13.7]; 12 females). POEM\u200a+\u200aF was technically successful in 23\/25 (92.0\u200a%). Significant dysphagia improvement was seen in all 25 patients (mean pre- and post-POEM Eckardt scores 8.21 [SD 1.08] and 0.1 [SD 0.3], respectively; P\u200a=\u200a0.001). Mean total procedure and fundoplication times were 115.6 (SD 27.2) minutes and 46.7 (SD 12.4) minutes, respectively; times reduced significantly after the initial five cases. Median follow-up was 12 months (interquartile range [IQR] 9\u201313). Intact wrap was seen in 19\/23 (82.6\u200a%). GER (abnormal esophageal acid exposure time [EAET]) was seen in 2\/18 (11.1\u200a%) and there was one reported GerdQ &gt;\u200a8.\u200aBorderline GER (asymptomatic grade A esophagitis, normal EAET) was identified in 4\/22 (18.2\u200a%). Three (12.0\u200a%) minor delayed adverse events occurred but required no intervention.<\/jats:p><jats:p>\n          Conclusions\u2002POEM\u200a+\u200aF was safe and reproducible. At 12 months\u2019 follow-up, incidence of post-POEM\u200a+\u200aF GER was low and acceptable.<\/jats:p>","DOI":"10.1055\/a-1332-5911","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T03:18:36Z","timestamp":1607483916000},"page":"1114-1121","source":"Crossref","is-referenced-by-count":44,"title":["Single-session endoscopic fundoplication after peroral endoscopic myotomy (POEM+F) for prevention of post gastroesophageal reflux \u2013 1-year follow-up study"],"prefix":"10.1055","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7632-814X","authenticated-orcid":false,"given":"Amol","family":"Bapaye","sequence":"additional","affiliation":[{"name":"Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parag","family":"Dashatwar","sequence":"additional","affiliation":[{"name":"Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Dharamsi","sequence":"additional","affiliation":[{"name":"Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra","family":"Pujari","sequence":"additional","affiliation":[{"name":"Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshal","family":"Gadhikar","sequence":"additional","affiliation":[{"name":"Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doy071","article-title":"The 2018 ISDE achalasia guidelines","volume":"31","author":"G Zaninotto","year":"2018","journal-title":"Dis Esophagus"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.gie.2019.04.231","article-title":"ASGE guideline on the management of achalasia","volume":"91","author":"M A Khashab","year":"2020","journal-title":"Gastrointest Endosc"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1111\/jgh.14097","article-title":"Management of achalasia cardia: expert consensus statements","volume":"33","author":"M Ramchandani","year":"2018","journal-title":"J Gastroenterol Hepatol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/MCG.0000000000001296","article-title":"Third space endoscopy: lessons learnt from a decade of submucosal endoscopy","volume":"54","author":"A Bapaye","year":"2020","journal-title":"J Clin Gastroenterol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jamcollsurg.2015.03.057","article-title":"Per-oral endoscopic myotomy: a series of 500 patients","volume":"221","author":"H Inoue","year":"2015","journal-title":"J Am Coll Surg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1007\/s00464-013-2913-8","article-title":"The International Per Oral Endoscopic Myotomy Survey (IPOEMS): a snapshot of the global POEM experience","volume":"27","author":"S N Stavropoulos","year":"2013","journal-title":"Surg Endosc"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/j.cgh.2017.01.031","article-title":"Efficacy and safety of peroral endoscopic myotomy for treatment of achalasia after failed Heller myotomy","volume":"15","author":"S Ngamruengphong","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1001\/jama.2019.8859","article-title":"Effect of peroral endoscopic myotomy vs pneumatic dilation on symptom severity and treatment outcomes among treatment-naive patients with achalasia: a randomized clinical trial","volume":"322","author":"F A Ponds","year":"2019","journal-title":"JAMA"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/SLA.0000000000002311","article-title":"Laparoscopic Heller myotomy versus peroral endoscopic myotomy (POEM) for achalasia: a systematic review and meta-analysis","volume":"267","author":"F Schlottmann","year":"2018","journal-title":"Ann Surg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1056\/NEJMoa1905380","article-title":"Endoscopic or surgical myotomy in patients with idiopathic achalasia","volume":"381","author":"Y B Werner","year":"2019","journal-title":"N Engl J Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.gie.2017.10.022","article-title":"GERD after per-oral endoscopic myotomy as compared with Heller\u2019s myotomy with fundoplication: a systematic review with meta-analysis","volume":"87","author":"A Repici","year":"2018","journal-title":"Gastrointest Endosc"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1055\/s-0043-105485","article-title":"Gastroesophageal reflux after peroral endoscopic myotomy: a multicenter case-control study","volume":"49","author":"V Kumbhari","year":"2017","journal-title":"Endoscopy"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1055\/s-0043-112490","article-title":"Will reflux kill POEM?","volume":"49","author":"T Rosch","year":"2017","journal-title":"Endoscopy"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1177\/000313481808400418","article-title":"Laparoscopic Heller myotomy and fundoplication: what is the evidence?","volume":"84","author":"F Rebecchi","year":"2018","journal-title":"Am Surg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1089\/lap.2019.0155","article-title":"Laparoscopic Heller myotomy: a fundoplication is necessary to control gastroesophageal reflux","volume":"29","author":"M Di Corpo","year":"2019","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/SLA.0b013e31818e43ab","article-title":"Endoscopic and surgical treatments for achalasia: a systematic review and meta-analysis","volume":"249","author":"G M Campos","year":"2009","journal-title":"Ann Surg"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ajg.2011.388","article-title":"Peroral endoscopic myotomy for the treatment of achalasia: a prospective single center study","volume":"107","author":"D von Renteln","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/den.12511","article-title":"Gastroesophageal reflux disease after peroral endoscopic myotomy: analysis of clinical, procedural and functional factors, associated with gastroesophageal reflux disease and esophagitis","volume":"28","author":"P Familiari","year":"2016","journal-title":"Dig Endosc"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1089\/lap.2019.0432","article-title":"Systematic review and Bayesian network meta-analysis comparing laparoscopic Heller myotomy, pneumatic dilatation, and peroral endoscopic myotomy for esophageal achalasia","volume":"30","author":"A Aiolfi","year":"2020","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s00464-019-06833-8","article-title":"Multicenter collaborative retrospective evaluation of peroral endoscopic myotomy for esophageal achalasia: analysis of data from more than 1300 patients at eight facilities in Japan","volume":"34","author":"H Shiwaku","year":"2020","journal-title":"Surg Endosc"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1007\/s00464-018-6522-4","article-title":"Peroral endoscopic myotomy leads to higher rates of abnormal esophageal acid exposure than laparoscopic Heller myotomy in achalasia","volume":"33","author":"M R Sanaka","year":"2019","journal-title":"Surg Endosc"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"doz106","DOI":"10.1093\/dote\/doz106","article-title":"Gastroesophageal reflux disease after peroral endoscopic myotomy: lest we forget what we already know","volume":"32","author":"R Bechara","year":"2019","journal-title":"Dis Esophagus"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1053\/j.gastro.2017.10.001","article-title":"Clinical practice update: the use of per-oral endoscopic myotomy in achalasia: expert review and best practice advice from the AGA Institute","volume":"153","author":"P J Kahrilas","year":"2017","journal-title":"Gastroenterology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1055\/a-0820-2731","article-title":"Peroral endoscopic myotomy and fundoplication: a novel NOTES procedure","volume":"51","author":"H Inoue","year":"2019","journal-title":"Endoscopy"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.vgie.2020.02.018","article-title":"Peroral endoscopic fundoplication: a brand-new intervention for GERD","volume":"5","author":"A Toshimori","year":"2020","journal-title":"VideoGIE"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"E73","DOI":"10.1055\/a-1000-8196","article-title":"Concomitant endoscopic fundoplication \u2013 can it reduce the risk of gastroesophageal reflux following peroral endoscopic myotomy?","volume":"52","author":"A Bapaye","year":"2020","journal-title":"Endoscopy"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1136\/gutjnl-2017-314722","article-title":"Modern diagnosis of GERD: the Lyon Consensus","volume":"67","author":"C P Gyawali","year":"2018","journal-title":"Gut"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/j.1365-2036.2009.04142.x","article-title":"Development of the GerdQ, a tool for the diagnosis and management of gastro-oesophageal reflux disease in primary care","volume":"30","author":"R Jones","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.gie.2009.10.027","article-title":"A lexicon for endoscopic adverse events: report of an ASGE workshop","volume":"71","author":"P B Cotton","year":"2010","journal-title":"Gastrointest Endosc"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12876-016-0452-1","article-title":"Prevalence of gastroesophageal reflux disease and its risk factors in a community-based population in southern India","volume":"16","author":"H Y Wang","year":"2016","journal-title":"BMC Gastroenterol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1136\/gutjnl-2019-318950","article-title":"Case of early Barrett cancer following peroral endoscopic myotomy","volume":"68","author":"Y Ichkhanian","year":"2019","journal-title":"Gut"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1136\/gutjnl-2015-310602","article-title":"Long-term results of the 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