{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:12Z","timestamp":1740126852818,"version":"3.37.3"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>With the advent of long-acting anti-vascular endothelial growth factor substances, \u201chealing of AMD (age-related macular degeneration)\u201d might be easily assumed due to prolonged treatment intervals. Adoption of the oncological concept of minimal residual disease for quiescent choroidal neovascularization (CNV) lesions might enhance the importance of continued monitoring, and spur research into the core of the disease, i.e., CNV biology.<\/jats:p>","DOI":"10.1055\/a-1333-3522","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T23:22:29Z","timestamp":1618442549000},"page":"700-702","source":"Crossref","is-referenced-by-count":0,"title":["Minimal Residual Disease in Neovascular Age-Related Macular Degeneration"],"prefix":"10.1055","volume":"238","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0279-4823","authenticated-orcid":false,"given":"Jakob","family":"Siedlecki","sequence":"additional","affiliation":[{"name":"Augenklinik der LMU, Klinikum der Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Pulido","sequence":"additional","affiliation":[{"name":"Department of Translational Ophthalmology, Wills Eye Hospital, Philadelphia, Pennsylvania, United States"},{"name":"Ophthalmology and Molecular Medicine, Mayo Clinic, Rochester, MN (Minnesota), United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Priglinger","sequence":"additional","affiliation":[{"name":"Augenklinik der LMU, Klinikum der Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrc.2017.125","article-title":"Targeting minimal residual disease: a path to cure?","volume":"18","author":"M R Luskin","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/sj.bmt.1703388","article-title":"Assessing minimal residual disease (MRD) in leukemia: a\u00a0changing definition and concept?","volume":"29","author":"E Paietta","year":"2002","journal-title":"Bone Marrow Transplant"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1097\/IAE.0000000000002851","article-title":"The Concept of Minimal Residual Disease in the Treatment and Staging of Vitreoretinal Lymphoma","volume":"40","author":"A W Stacey","year":"2020","journal-title":"Retina"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1056\/NEJMoa1815111","article-title":"Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy","volume":"381","author":"M L Gantner","year":"2019","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ajo.2016.06.042","article-title":"Optical Coherence Tomography Angiography: A Useful Tool for Diagnosis of Treatment-Naive Quiescent Choroidal Neovascularization","volume":"169","author":"A Carnevali","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"6886","DOI":"10.1167\/iovs.13-11665","article-title":"Functional characterization and multimodal imaging of treatment-na\u00efve \u201cquiescent\u201d choroidal neovascularization","volume":"54","author":"G Querques","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.oret.2018.02.002","article-title":"Natural History of Treatment-Na\u00efve Quiescent Choroidal Neovascularization in Age-Related Macular Degeneration Using OCT Angiography","volume":"2","author":"A Carnevali","year":"2018","journal-title":"Ophthalmol Retina"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ajo.2017.07.009","article-title":"Treatment-Naive Quiescent Choroidal Neovascularization in Geographic Atrophy Secondary to Nonexudative Age-Related Macular Degeneration","volume":"182","author":"V Capuano","year":"2017","journal-title":"Am J Ophthalmol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.oret.2019.05.013","article-title":"Outcomes of Suspending VEGF Inhibitors for Neovascular Age-Related Macular Degeneration When Lesions Have Been Inactive for 3 Months","volume":"3","author":"V Nguyen","year":"2019","journal-title":"Ophthalmol Retina"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.oret.2017.07.009","article-title":"Recurrence Rate of Choroidal Neovascularization in Neovascular Age-Related Macular Degeneration Managed with a Treat-Extend-Stop Protocol","volume":"2","author":"S D Adrean","year":"2018","journal-title":"Ophthalmol Retina"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/IAE.0000000000001923","article-title":"Exit strategy in a treat-and-extend regimen for exudative age-related macular degeneration","volume":"39","author":"P Arendt","year":"2019","journal-title":"Retina"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3322\/caac.21498","article-title":"Local Cancer Recurrence: The Realities, Challenges, and Opportunities for New Therapies","volume":"68","author":"D A Mahvi","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1097\/IAE.0000000000000819","article-title":"Optical coherence tomography angiography features of subretinal fibrosis in age-related macular degeneration","volume":"35","author":"A Miere","year":"2015","journal-title":"Retina"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41433-018-0229-6","article-title":"The diagnostic accuracy of OCT angiography in naive and treated neovascular age-related macular degeneration: a review","volume":"33","author":"R Perrott-Reynolds","year":"2019","journal-title":"Eye (Lond)"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.oret.2019.09.016","article-title":"Type 1 Choroidal Neovascularization Is Associated with Reduced Localized Progression of Atrophy in Age-Related Macular Degeneration","volume":"4","author":"M Pfau","year":"2020","journal-title":"Ophthalmol Retina"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1333-3522.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T22:35:58Z","timestamp":1624401358000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1333-3522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,14]]},"references-count":15,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2021,6,22]]},"published-print":{"date-parts":[[2021,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1333-3522","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"type":"print","value":"0023-2165"},{"type":"electronic","value":"1439-3999"}],"subject":[],"published":{"date-parts":[[2021,4,14]]}}}