{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:30:05Z","timestamp":1759775405919},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nBackground MRI has shortcomings in differentiation between tumor tissue and post-therapeutic changes in pretreated brain tumor patients.<\/jats:p><jats:p>\nPatients We assessed 22 static FET-PET\/CT-scans of 17 pediatric patients (median age 12 years, range 2\u201316 years, ependymoma n=4, medulloblastoma n=4, low-grade glioma n=6, high-grade glioma n=3, germ cell tumor n=1, choroid plexus tumor n=1, median follow-up: 112 months) with multimodal treatment.<\/jats:p><jats:p>\nMethod FET-PET\/CT-scans were analyzed visually by 3 independent nuclear medicine physicians. Additionally quantitative FET-Uptake for each lesion was determined by calculating standardized uptake values (SUVmaxT\/SUVmeanB, SUVmeanT\/SUVmeanB). Histology or clinical follow-up served as reference.<\/jats:p><jats:p>\nResults Static FET-PET\/CT reliably distinguished between tumor tissue and post-therapeutic changes in 16 out of 17 patients. It identified correctly vital tumor tissue in 13 patients and post-therapeutic changes in 3 patients. SUV-based analyses were less sensitive than visual analyses. Except from a choroid plexus carcinoma, all tumor entities showed increased FET-uptake.<\/jats:p><jats:p>\nDiscussion Our study comprises a limited number of patients but results corroborate the ability of FET to detect different brain tumor entities in pediatric patients and discriminate between residual\/recurrent tumor and post-therapeutic changes.<\/jats:p><jats:p>\nConclusions We observed a clear benefit from additional static FET-PET\/CT-scans when conventional MRI identified equivocal lesions in pretreated pediatric brain tumor patients. These results warrant prospective studies that should include dynamic scans.<\/jats:p>","DOI":"10.1055\/a-1335-4844","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T01:19:56Z","timestamp":1613611196000},"page":"127-134","source":"Crossref","is-referenced-by-count":9,"title":["Benefit of Static FET PET in Pretreated Pediatric Brain Tumor Patients with Equivocal Conventional MRI Results"],"prefix":"10.1055","volume":"233","author":[{"given":"Frederik","family":"Grosse","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Department of Gastroenterology and Diabetology, St\u00e4dtisches Klinikum Brandenburg GmbH, Brandenburg an der Havel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Wedel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich-Wilhelm","family":"Thomale","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Section of pediatric Neurosurgery, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Steffen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arend","family":"Koch","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winfried","family":"Brenner","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michail","family":"Plotkin","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Nuklearmedizin, Vivantes-Netzwerk fur Gesundheit GmbH, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo Hern\u00e1iz","family":"Driever","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-18-1965","article-title":"The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma","author":"J L Buhl","year":"2018","journal-title":"Clin Cancer Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s11060-011-0794-z","article-title":"Spurious progression in pediatric brain tumors","volume":"107","author":"S Chawla","year":"2012","journal-title":"J Neurooncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/neuonc\/nop031","article-title":"High-dose carboplatin, thiotepa, and etoposide with autologous stem cell rescue for patients with previously irradiated recurrent medulloblastoma","volume":"12","author":"I J Dunkel","year":"2010","journal-title":"Neuro Oncol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.148734","article-title":"The usefulness of dynamic O-(2-[18F]fluoroethyl)-L-tyrosine-PET in the clinical evaluation of brain tumors in children and adolescents. 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