{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:56:09Z","timestamp":1790636169063,"version":"4.1.0"},"reference-count":285,"publisher":"Georg Thieme Verlag KG","issue":"S 01","license":[{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Speicheldr\u00fcsenerkrankungen sind, insgesamt gesehen eher selten. In der Europ\u00e4ischen Union (EU) gilt eine Erkrankung als selten, wenn nicht mehr als 5 von 10,000 Menschen in der EU von ihr betroffen sind. Allein in Deutschland leben Sch\u00e4tzungen zufolge etwa 4 Millionen Menschen mit einer seltenen Erkrankung, in der gesamten EU geht man von 30 Millionen aus 1. Die meisten in der vorliegenden Arbeit beschriebenen Krankheitsbilder der Speicheldr\u00fcsen und des N. facialis fallen unter diese Kategorie. Sie bilden eine sehr heterogene Gruppe, deren Behandlung sich auf spezialisierte Zentren konzentriert. Dennoch ist es f\u00fcr den HNO-Arzt unerl\u00e4sslich, auch diese seltenen Erkrankungen zu erkennen und zu diagnostizieren, um dann die richtigen therapeutischen Schritte einzuleiten. Die Arbeit ist eine Zusammenstellung des gesamten Spektrums angeborener und erworbener seltener Speicheldr\u00fcsen- und N. facialis-Erkrankungen. Dabei werden die \u00c4tiologien entz\u00fcndlicher Erkrankungen, Autoimmunerkrankungen und Tumoren ber\u00fccksichtigt. F\u00fcr die einzelnen Themenkomplexe wurde, soweit vorhanden, die aktuelle Literatur ausgewertet und f\u00fcr den Leser in Fakten zusammengefasst. Dazu wird auf die Entwicklung neuer Verfahren in Diagnostik, Bildgebung und Therapie eingegangen. Auch genetische Hintergr\u00fcnde von Tumorerkrankungen bei Speicheldr\u00fcsentumoren und die Trends in der Behandlung tumor\u00f6ser L\u00e4sionen des N. facialis werden aufgegriffen. Des Weiteren werden auch seltene Erkrankungen der Speicheldr\u00fcsen im Kindesalter betrachtet. Diese k\u00f6nnen zwar teilweise auch bei Erwachsenen vorkommen, unterscheiden sich aber doch in H\u00e4ufigkeit und Symptomatik. Auf Grund der Seltenheit der hier abgehandelten Erkrankungen ist es zu empfehlen, diese in spezialisierten Zentren mit entsprechender Erfahrung zu behandeln. Abschlie\u00dfend werden die Schwierigkeiten der Studiendurchf\u00fchrung und die Problematik der Erstellung von Krankheitsregistern beim Thema Speicheldr\u00fcsenerkrankungen besprochen, da diese auf Grund der allgemeinen Seltenheit dieser Pathologien besonders relevant sind.<\/jats:p>","DOI":"10.1055\/a-1337-6994","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T23:32:31Z","timestamp":1619825551000},"page":"S1-S28","source":"Crossref","is-referenced-by-count":5,"special_numbering":"S","title":["Seltene Erkrankungen der Speicheldr\u00fcsen und des Nervus Facialis"],"prefix":"10.1055","volume":"100","author":[{"given":"Claudia","family":"Scherl","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universit\u00e4tsklinikum Mannheim"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,4,30]]},"reference":[{"key":"ref2","first-page":"1","article-title":"Assyrian Medical Texts","volume":"17","author":"R C Thompson","year":"1924","journal-title":"Proc R Soc Med"},{"key":"ref3","first-page":"403","article-title":"A brief history of salivary gland surgery","volume":"44","author":"G M Melo","year":"2017","journal-title":"Rev Col Bras Cir"},{"key":"ref6","first-page":"57","article-title":"Ranula in the Arab Medical Heritage JISHIM","volume":"5","author":"A N Kaadan","year":"2006"},{"key":"ref7","first-page":"1543","volume-title":"De humani corporis fabrica libre septem","author":"A Vesalius"},{"key":"ref8","first-page":"411","article-title":"Thomas Wharton\u2019s Adenographia","volume":"42","author":"H J Cook","year":"1998","journal-title":"Med Hist"},{"key":"ref10","volume-title":"A general system of surgery in three parts","author":"L Heister","year":"1750"},{"key":"ref12","volume-title":"Die Versuche mit dem Schwefel\u00e4ther","author":"J F Heyfelder","year":"1847"},{"key":"ref13","volume-title":"Salivary Gland Disorders and Diseases: Diagnosis and Management","author":"PatrickJ. 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