{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T05:58:36Z","timestamp":1723615116551},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Ziel\u2002Dyspnoe ist ein h\u00e4ufiges und schwer beeintr\u00e4chtigendes Krankheitssymptom bei Patienten mit fortgeschrittenem Lungenkarzinom. Exogene wie endogene Faktoren tragen zum subjektiven Symptom Luftnot bei. Um eine effektive Therapie einleiten zu k\u00f6nnen, ist die Kenntnis von beeinflussbaren Faktoren essenziell. Mit dem Ziel, die Atemnot gezielter behandeln zu k\u00f6nnen, wurde in dieser Arbeit die Auswirkung von Begleitfaktoren und Komorbidit\u00e4ten auf den Schweregrad von Luftnot bei Patienten mit Lungenkarzinom untersucht.<\/jats:p><jats:p>\n          Methode\u2002Im Rahmen einer prospektiven, monozentrischen Beobachtungsstudie wurde der Schweregrad der Atemnot bei Patienten mit fortgeschrittenem Lungenkarzinom anhand des mMRC-Scores abgefragt und standardisiert nach kardialer oder pulmonaler Komorbidit\u00e4t befragt. Zudem wurden Schmerzsymptomatik und psychische Belastung der Patienten durch die Tumorerkrankung anhand numerischer Ratingskalen (NRS) abgefragt.<\/jats:p><jats:p>\n          Ergebnisse\u200225 (48,1\u200a%) von 52 eingeschlossenen Lungenkarzinompatienten gaben m\u00e4\u00dfige bis starke Dyspnoe an. Vorbekannte COPD, kardiopulmonale Begleiterkrankungen, starke Schmerzen, eine obstruktive Ventilationsst\u00f6rung in der Lungenfunktion sowie nachweisbare Pleuraerg\u00fcsse korrelierten in der logistischen Regressionsanalyse mit dem Auftreten von Dyspnoeschweregraden \u2265\u200a\u200a3 in der mMRC-Skala. In dieser Untersuchung war auch das niedrigere UICC-Stadium III bzw. eine M0-Situation mit einer h\u00f6heren Wahrscheinlichkeit einer schweren Dyspnoe korreliert als ein h\u00f6heres Stadium IV nach UICC.<\/jats:p><jats:p>\n          Schlussfolgerung\u2002Unsere Untersuchung best\u00e4tigt die klinische Relevanz von Dyspnoe bei Lungenkarzinompatienten. Die Wahrscheinlichkeit f\u00fcr das Auftreten dyspnoeischer Beschwerden wird durch Begleitsymptome wie starke Schmerzen und insbesondere durch das Vorhandensein von kardialen oder pulmonalen Komorbidit\u00e4ten wesentlich beeinflusst. Eine effektive Behandlung von Luftnot sollte daher diese begleitenden Faktoren in der Therapie ber\u00fccksichtigen.<\/jats:p>","DOI":"10.1055\/a-1340-5609","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T01:21:11Z","timestamp":1613611271000},"page":"353-359","source":"Crossref","is-referenced-by-count":1,"title":["Dyspnoe und Komorbidit\u00e4t beim Lungenkarzinom: Warum die Anamnese so wichtig ist"],"prefix":"10.1055","volume":"75","author":[{"given":"A.","family":"Gr\u00fcnewaldt","sequence":"additional","affiliation":[{"name":"Schwerpunkt Pneumologie\/Allergologie, Medizinische Klinik 1, Universit\u00e4tsklinikum, Goethe-Universit\u00e4t Frankfurt am Main"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"St\u00fctzle","sequence":"additional","affiliation":[{"name":"Schwerpunkt Pneumologie\/Allergologie, Medizinische Klinik 1, Universit\u00e4tsklinikum, Goethe-Universit\u00e4t Frankfurt am Main"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lehn","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biostatistik und Mathematische Modellierung, Fachbereich Medizin, Goethe-Universit\u00e4t Frankfurt am Main"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Rohde","sequence":"additional","affiliation":[{"name":"Schwerpunkt Pneumologie\/Allergologie, Medizinische Klinik 1, Universit\u00e4tsklinikum, Goethe-Universit\u00e4t Frankfurt am Main"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.cllc.2017.02.008","article-title":"Emotional Problems, Quality of Life, and Symptom Burden in Patients With Lung Cancer","volume":"18","author":"E J Morrison","year":"2017","journal-title":"Clin Lung Cancer"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.3349\/ymj.2016.57.5.1063","article-title":"Dyspnea as a Prognostic Factor in Patients with Non-Small Cell Lung Cancer","volume":"57","author":"W H Ban","year":"2016","journal-title":"Yonsei Med J"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.ejon.2007.09.006","article-title":"Dyspnea experience in patients with lung cancer in palliative care","volume":"12","author":"I Henoch","year":"2008","journal-title":"Eur J Oncol Nurs"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/ncponc1034","article-title":"The etiology and management of intractable breathlessness in patients with advanced cancer: a systematic review of pharmacological therapy","volume":"5","author":"S Booth","year":"2008","journal-title":"Nat Clin Pract Oncol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"44","DOI":"10.7748\/ns2012.11.27.13.44.c9450","article-title":"Managing breathlessness in patients with lung cancer","volume":"27","author":"L Cairns","year":"2012","journal-title":"Nurs Stand"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/S0885-3924(98)00065-7","article-title":"Dyspnea in the Advanced Cancer Patient","volume":"16","author":"D J Dudgeon","year":"1998","journal-title":"J Pain Symptom Manage"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1056\/NEJMoa1911793","article-title":"Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial","volume":"382","author":"H J de Koning","year":"2020","journal-title":"N Engl J Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.jpainsymman.2009.09.017","article-title":"Do the trajectories of dyspnea differ in prevalence and intensity by diagnosis at the end of life? 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