{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:41Z","timestamp":1740126881408,"version":"3.37.3"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Herpes simplex Virus Typ 1 oder 2 (HSV-1\/2) Infektionen bei Neugeborenen sind selten, aber insbesondere bei systemischen Verlauf mit einer hohen Morbidit\u00e4t und Mortalit\u00e4t belastet. Fr\u00fchgeborene geh\u00f6ren aufgrund ihrer immunologischen Unreife und der h\u00e4ufig unspezifischen, Sepsis-\u00e4hnlichen Klinik einer HSV-1\/2 Infektion zu einer besonders gef\u00e4hrdeten Gruppe. Wir stellen das diagnostische und therapeutische Management bei 2 unreifen Fr\u00fchgeborenen mit systemischer HSV Infektion vor. Beide erhielten entsprechend aktuellen Empfehlungen nach initialer parenteraler Intensivtherapie eine orale Aciclovir Suppressionstherapie.<\/jats:p>","DOI":"10.1055\/a-1345-9835","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:21:54Z","timestamp":1612311714000},"page":"441-444","source":"Crossref","is-referenced-by-count":1,"title":["Infektion durch Herpes simplex Virus bei zwei unreifen Fr\u00fchgeborenen \u2013 Diagnostisches und therapeutisches Management"],"prefix":"10.1055","volume":"225","author":[{"given":"Roland","family":"Haase","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Neonatologie und P\u00e4diatrische Intensivmedizin, Universit\u00e4tsklinikum Halle (Saale), Martin-Luther-Universit\u00e4t Halle-Wittenberg, Halle (Saale), Deutschland"},{"name":"Klinik f\u00fcr Neonatologie und Kinderintensivmedizin, St. Elisabeth & St. Barbara Krankenhaus, Halle (Saale), Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6201-9303","authenticated-orcid":false,"given":"Gregor","family":"Seliger","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik und Poliklinik f\u00fcr Geburtshilfe und Pr\u00e4natalmedizin, Universit\u00e4tsklinikum Halle (Saale), Martin-Luther-Universit\u00e4t Halle-Wittenberg, Halle (Saale), Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Baier","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Neonatologie und P\u00e4diatrische Intensivmedizin, Universit\u00e4tsklinikum Halle (Saale), Martin-Luther-Universit\u00e4t Halle-Wittenberg, Halle (Saale), Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1542\/hpeds.2019-0001","article-title":"Inconsistent Management of Neonatal Herpes Simplex Virus Infections","volume":"9","author":"M Keuning","year":"2019","journal-title":"Hosp Pediatr"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1542\/peds.2011-0177","article-title":"Delayed acyclovir therapy and death among neonates with herpes simplex virus infection","volume":"128","author":"S S Shah","year":"2011","journal-title":"Pediatrics"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e1612","DOI":"10.1542\/peds.2005-1228","article-title":"Herpes simplex virus infections in preterm infants","volume":"118","author":"D P O\u2019Riordan","year":"2006","journal-title":"Pediatrics"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1053\/j.semperi.2018.02.004","article-title":"Neonatal herpes simplex virus infections","volume":"42","author":"S G Pinninti","year":"2018","journal-title":"Seminars in perinatology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e635","DOI":"10.1542\/peds.2012-3216","article-title":"Committee on infectious diseases; Committee on fetus and newborn. Guidance on management of asymptomatic neonates born to women with active genital herpes lesions","volume":"131","author":"D Kimberlin","year":"2013","journal-title":"Pediatrics"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"385697","DOI":"10.1155\/2012\/385697","article-title":"Herpes simplex virus infection in pregnancy","volume":"2012","author":"G Straface","year":"2012","journal-title":"Infect Dis Obstet Gynecol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.3928\/19382359-20170112-01","article-title":"Herpes Simplex Virus in the Neonate","volume":"46","author":"A Wang","year":"2017","journal-title":"Pediatr Ann"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1111\/ddg.13529","article-title":"Vertical transmission of herpes simplex virus: an update","volume":"16","author":"A K Bhatta","year":"2018","journal-title":"Journal of the German Society of Dermatology: JDDG"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"387","DOI":"10.3233\/NPM-190334","article-title":"Evaluation of suspected neonatal herpes simplex virus infection in preterm versus term newborns in the neonatal intensive care unit","volume":"13","author":"N Fernandes","year":"2020","journal-title":"J Neonatal Perinatal Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1001\/jama.289.2.203","article-title":"Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant","volume":"289","author":"Z Brown","year":"2003","journal-title":"JAMA"},{"key":"ref12","first-page":"532","volume-title":"Herpes simplex Infektionen. In: DGPI Handbuch: Infektionen bei Kindern und Jugendlichen","author":"V Schuster","year":"2018","edition":"7. Aufl."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1097\/00006454-199803000-00017","article-title":"Use of Guthrie cards for the early diagnosis of neonatal herpes simplex virus disease","volume":"17","author":"M Barbi","year":"1998","journal-title":"Pediatr Infec Dis J"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"CD004206","DOI":"10.1002\/14651858","article-title":"Antiviral agents for treatment of herpes simplex virus infection in neonates","volume":"2009","author":"C A Jones","year":"2009","journal-title":"The Cochrane database of systematic reviews"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1097\/MOP.0000000000000311","article-title":"Drug-induced acute kidney injury in neonates","volume":"28","author":"M H Hanna","year":"2016","journal-title":"Current opinion in pediatrics"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1056\/NEJMoa1003509","article-title":"Oral acyclovir suppression and neurodevelopment after neonatal herpes","volume":"365","author":"D W Kimberlin","year":"2011","journal-title":"N Engl J Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1056\/NEJMc1112822","article-title":"Oral acyclovir suppression after neonatal herpes","volume":"366","author":"D Bargiela","year":"2012","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.jiac.2015.08.005","article-title":"Recurrent neonatal herpes simplex virus infection with central nervous system disease after completion of a 6-month course of suppressive therapy: Case report","volume":"21","author":"K Kato","year":"2015","journal-title":"J Infect Chemother"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1542\/peds.2004-0777","article-title":"Herpes simplex virus encephalitis during suppressive therapy with acyclovir in a premature infant","volume":"115","author":"M Fonseca-Aten","year":"2005","journal-title":"Pediatrics"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1097\/QCO.0000000000000288","article-title":"Antiviral resistance in herpes simplex virus and varicella-zoster virus infections: diagnosis and management","volume":"29","author":"J Piret","year":"2016","journal-title":"Curr Opin Infect Dis"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1345-9835.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T21:16:09Z","timestamp":1633727769000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1345-9835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,2]]},"references-count":19,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2021,10,7]]},"published-print":{"date-parts":[[2021,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1345-9835","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"type":"print","value":"0948-2393"},{"type":"electronic","value":"1439-1651"}],"subject":[],"published":{"date-parts":[[2021,2,2]]}}}