{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T21:00:17Z","timestamp":1780520417182,"version":"3.54.1"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of anabolic\u2013androgenic steroid (AAS) abuse on the contact activation system (CAS) is not known in detail. We hypothesized that current AAS abuse reduces the kallikrein-generating capacity of CAS significantly and investigated the impact of AAS on the proteins and capacity of CAS in current and former AAS abusers and healthy age-matched controls. Men 18 to 50 years of age were included as current AAS abusers, former AAS abusers, or controls. Blood samples were collected after overnight fasting. Kallikrein generation (lag time, peak height, and endogenous kallikrein potential [EKP]), coagulation factor XII (FXII), prekallikrein, high-molecular-weight kininogen (HK), and Complement C1 esterase inhibitor (C1inh) were assessed. Groups were compared by analysis of variance or Kruskal\u2013Wallis test and probabilities were corrected for multiple comparisons. Associations were evaluated by linear regression models. The EKP was significantly reduced in current (n\u2009=\u200937) AAS abusers (984\u2009\u00b1\u2009328 nmol\/L\u2009\u00d7\u2009min) compared with former (n\u2009=\u200933) abusers (1,543\u2009\u00b1\u2009481 nmol\/L\u2009\u00d7\u2009min) and controls (n\u2009=\u200930) (1,521\u2009\u00b1\u2009339 nmol\/L\u2009\u00d7\u2009min), p\u2009&lt;\u20090.001. Current abusers had higher levels of FXII and C1inh and lower levels of prekallikrein and HK than controls, p \u2264 0.025. Stepwise regression analysis showed that EKP was associated with C1inh and prekallikrein in current AAS abusers, R\n          2\u2009=\u20090.70, p\u2009&lt;\u20090.001. We conclude that current AAS abuse reduces the kallikrein-generating capacity of CAS by increasing the concentration of C1inh and reducing the concentration of prekallikrein. These changes may contribute to the anti-inflammatory effect of testosterone.<\/jats:p>","DOI":"10.1055\/a-1346-3384","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T23:43:11Z","timestamp":1609890191000},"page":"1268-1273","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Anabolic\u2013Androgenic Steroid Abuse on the Contact Activation System"],"prefix":"10.1055","volume":"121","author":[{"given":"Johannes Jakobsen","family":"Sidelmann","sequence":"additional","affiliation":[{"name":"Unit for Thrombosis Research, Department of Regional Health Research, University of Southern, Esbjerg, Denmark"},{"name":"Department of Clinical Biochemistry, University Hospital of Southern Denmark, Esbjerg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen Brodersen","family":"Gram","sequence":"additional","affiliation":[{"name":"Unit for Thrombosis Research, Department of Regional Health Research, University of Southern, Esbjerg, Denmark"},{"name":"Department of Clinical Biochemistry, University Hospital of Southern Denmark, Esbjerg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaseelan","family":"Palarasah","sequence":"additional","affiliation":[{"name":"Unit for Thrombosis Research, Department of Regional Health Research, University of Southern, Esbjerg, Denmark"},{"name":"Department of Clinical Biochemistry, University Hospital of Southern Denmark, Esbjerg, Denmark"},{"name":"Department of Cancer and Inflammation Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon Jarl\u00f8v","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Kistorp","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,2,28]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/andr.12774","article-title":"Testosterone replacement therapy","volume":"8","author":"A Barbonetti","year":"2020","journal-title":"Andrology"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ecl.2019.01.004","article-title":"Transmasculine hormone therapy","volume":"48","author":"J Defreyne","year":"2019","journal-title":"Endocrinol Metab Clin North 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