{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:33:51Z","timestamp":1777631631686,"version":"3.51.4"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003A hypercoagulable condition was described in patients with coronavirus disease 2019 (COVID-19) and proposed as a possible pathogenic mechanism contributing to disease progression and lethality.<\/jats:p><jats:p>\n          Aim\u2003We evaluated if in-hospital administration of heparin improved survival in a large cohort of Italian COVID-19 patients.<\/jats:p><jats:p>\n          Methods\u2003In a retrospective observational study, 2,574 unselected patients hospitalized in 30 clinical centers in Italy from February 19, 2020 to June 5, 2020 with laboratory-confirmed severe acute respiratory syndrome coronavirus-2 infection were analyzed. The primary endpoint in a time-to event analysis was in-hospital death, comparing patients who received heparin (low-molecular-weight heparin [LMWH] or unfractionated heparin [UFH]) with patients who did not. We used multivariable Cox proportional-hazards regression models with inverse probability for treatment weighting by propensity scores.<\/jats:p><jats:p>\n          Results\u2003Out of 2,574 COVID-19 patients, 70.1% received heparin. LMWH was largely the most used formulation (99.5%). Death rates for patients receiving heparin or not were 7.4 and 14.0 per 1,000 person-days, respectively. After adjustment for propensity scores, we found a 40% lower risk of death in patients receiving heparin (hazard ratio\u2009=\u20090.60; 95% confidence interval: 0.49\u20130.74; E-value\u2009=\u20092.04). This association was particularly evident in patients with a higher severity of disease or strong coagulation activation.<\/jats:p><jats:p>\n          Conclusion\u2003In-hospital heparin treatment was associated with a lower mortality, particularly in severely ill COVID-19 patients and in those with strong coagulation activation. The results from randomized clinical trials are eagerly awaited to provide clear-cut recommendations.<\/jats:p>","DOI":"10.1055\/a-1347-6070","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T23:57:19Z","timestamp":1610063839000},"page":"1054-1065","source":"Crossref","is-referenced-by-count":85,"title":["Heparin in COVID-19 Patients Is Associated with Reduced In-Hospital Mortality: The Multicenter Italian CORIST Study"],"prefix":"10.1055","volume":"121","author":[{"given":"Augusto","family":"Di Castelnuovo","sequence":"first","affiliation":[{"name":"Mediterranea Cardiocentro, Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4569-1186","authenticated-orcid":false,"given":"Simona","family":"Costanzo","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Antinori","sequence":"additional","affiliation":[{"name":"UOC Immunodeficienze Virali, National Institute for Infectious Diseases \u201cL. Spallanzani,\u201d IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nausicaa","family":"Berselli","sequence":"additional","affiliation":[{"name":"Section of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Blandi","sequence":"additional","affiliation":[{"name":"Universit\u00e0 di Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marialaura","family":"Bonaccio","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Cauda","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A, Gemelli IRCCS, Rome, Italy"},{"name":"Dipartimento di Sicurezza e Bioetica Sede di Roma, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Guaraldi","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit, Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Menicanti","sequence":"additional","affiliation":[{"name":"IRCCS Policlinico San Donato, San Donato, Milanese (MI), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Mennuni","sequence":"additional","affiliation":[{"name":"University of Eastern Piedmont, Maggiore della Carit\u00e0 Hospital, Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giustino","family":"Parruti","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Azienda Sanitaria Locale (AUSL) di Pescara, Pescara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Patti","sequence":"additional","affiliation":[{"name":"University of Eastern Piedmont, Maggiore della Carit\u00e0 Hospital, Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Santilli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging, Clinica Medica, \u201cSS. Annunziata\u201d Hospital and University of Chieti, Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Signorelli","sequence":"additional","affiliation":[{"name":"School of Medicine, Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Vergori","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d-IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Abete","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche Traslazionali, Universit\u00e0 degli studi di Napoli \u201cFederico II,\u201d Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Ageno","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Insubria, Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Agodi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \u201cG.F. Ingrassia,\u201d University of Catania; AOU Policlinico \u201cG. Rodolico - San Marco,\u201d Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piergiuseppe","family":"Agostoni","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino IRCCS, Milan, Italy"},{"name":"Section of Cardiovascular, Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Aiello","sequence":"additional","affiliation":[{"name":"UOC, Anestesia e Rianimazione, Dipartimento di Chirurgia Generale Ospedale Morgagni-Pierantoni, Forl\u00ec, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Al Moghazi","sequence":"additional","affiliation":[{"name":"UOC Infezioni Sistemiche dell'Immunodepresso, National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Arboretti","sequence":"additional","affiliation":[{"name":"Department of Civil Environmental and Architectural Engineering, University of Padova, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marinella","family":"Astuto","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Medical-Surgical Specialties, University of Catania, U.O. Anestesia, Rianimazione 1. P.O. \u201cG. Rodolico,\u201d AOU Policlinico \u201cG. 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Miulli, Acquaviva delle Fonti, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Leone","sequence":"additional","affiliation":[{"name":"UOC di Pneumologia, P.O. San Giuseppe Moscati, Taranto, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Maccagni","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ospedale di Cremona, Cremona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferruccio","family":"Madaro","sequence":"additional","affiliation":[{"name":"COVID-19 Unit, EE Ospedale Regionale F. 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