{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:47:45Z","timestamp":1791560865280,"version":"4.3.4"},"reference-count":137,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aside from their canonical role in hemostasis, it is increasingly recognized that platelets have inflammatory functions and can regulate both adaptive and innate immune responses. The main topic this review aims to cover is the proinflammatory effects and side effects of platelet transfusion. Platelets prepared for transfusion are subject to stress injury upon collection, preparation, and storage. With these types of stress, they undergo morphologic, metabolic, and functional modulations which are likely to induce platelet activation and the release of biological response modifiers (BRMs). As a consequence, platelet concentrates (PCs) accumulate BRMs during processing and storage, and these BRMs are ultimately transfused alongside platelets. It has been shown that BRMs present in PCs can induce immune responses and posttransfusion reactions in the transfusion recipient. Several recent reports within the transfusion literature have investigated the concept of platelets as immune cells. Nevertheless, current and future investigations will face the challenge of encompassing the immunological role of platelets in the scope of transfusion.<\/jats:p>","DOI":"10.1055\/a-1347-6551","type":"journal-article","created":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T00:05:15Z","timestamp":1615593915000},"page":"128-135","source":"Crossref","is-referenced-by-count":27,"title":["Effects and Side Effects of Platelet Transfusion"],"prefix":"10.1055","volume":"41","author":[{"given":"Fabrice","family":"Cognasse","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang Auvergne-Rh\u00f4ne-Alpes, Saint-\u00c9tienne, France"},{"name":"SAINBIOSE, INSERM U1059, University of Lyon, Universit\u00e9 Jean-Monnet-Saint-Etienne, France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Hally","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anaesthesia, University of Otago, Wellington, New 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Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.3389\/fimmu.2019.01478","article-title":"Platelet inflammatory response to stress","volume":"10","author":"F Cognasse","year":"2019","journal-title":"Front Immunol"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1177\/1753425918789255","article-title":"Start a fire, kill the bug: the role of platelets in inflammation and infection","volume":"24","author":"C Deppermann","year":"2018","journal-title":"Innate Immun"},{"issue":"09","key":"ref5","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.4049\/jimmunol.1900899","article-title":"Platelets in inflammation and resolution","volume":"203","author":"A Margraf","year":"2019","journal-title":"J Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.3389\/fimmu.2018.02712","article-title":"Role of platelets in leukocyte recruitment and resolution of inflammation","volume":"9","author":"J Rossaint","year":"2018","journal-title":"Front Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fmed.2018.00042","article-title":"The non-hemostatic aspects of transfused platelets","volume":"5","author":"C Sut","year":"2018","journal-title":"Front Med (Lausanne)"},{"issue":"09","key":"ref8","doi-asserted-by":"crossref","first-page":"e106239","DOI":"10.1371\/journal.pone.0106239","article-title":"Role of Siglec-7 in apoptosis in human platelets","volume":"9","author":"K A Nguyen","year":"2014","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fimmu.2015.00083","article-title":"The inflammatory role of platelets via their TLRs and Siglec receptors","volume":"6","author":"F Cognasse","year":"2015","journal-title":"Front Immunol"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.thromres.2004.03.023","article-title":"Expression of toll-like receptors on 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Gear","year":"2003","journal-title":"Microcirculation"},{"issue":"05","key":"ref40","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1046\/j.1537-2995.1999.39050498.x","article-title":"Effects of filtration and gamma radiation on the accumulation of RANTES and transforming growth factor-beta1 in apheresis platelet concentrates during storage","volume":"39","author":"M Fujihara","year":"1999","journal-title":"Transfusion"},{"issue":"08","key":"ref41","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1046\/j.1537-2995.2003.00458.x","article-title":"Biologic activity of RANTES in apheresis PLT concentrates and its involvement in nonhemolytic transfusion reactions","volume":"43","author":"S Wakamoto","year":"2003","journal-title":"Transfusion"},{"issue":"03","key":"ref42","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1537-2995.2011.03310.x","article-title":"Allergic agonists in apheresis platelet products are associated with allergic transfusion reactions","volume":"52","author":"W J Savage","year":"2012","journal-title":"Transfusion"},{"issue":"04","key":"ref43","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/vox.12064","article-title":"Parallel comparison of apheresis-collected platelet concentrates stored in four different additive solutions","volume":"105","author":"M Nogawa","year":"2013","journal-title":"Vox Sang"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fimmu.2015.00048","article-title":"Breaking the mold: transcription factors in the anucleate platelet and platelet-derived microparticles","volume":"6","author":"K L Lannan","year":"2015","journal-title":"Front Immunol"},{"issue":"05","key":"ref45","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/MOH.0000000000000166","article-title":"The diversity of platelet microparticles","volume":"22","author":"E Boilard","year":"2015","journal-title":"Curr Opin Hematol"},{"issue":"01","key":"ref46","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/09537104.2011.595850","article-title":"Platelet-derived microparticles cause CD154-dependent activation of dendritic cells","volume":"23","author":"S Nomura","year":"2012","journal-title":"Platelets"},{"issue":"14","key":"ref47","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1182\/blood-2014-08-593806","article-title":"Platelet microparticles are not created equal","volume":"124","author":"J F Dong","year":"2014","journal-title":"Blood"},{"issue":"07","key":"ref48","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1111\/trf.15300","article-title":"Platelet-derived extracellular vesicles convey mitochondrial DAMPs in platelet concentrates and their levels are associated with adverse reactions","volume":"59","author":"G Marcoux","year":"2019","journal-title":"Transfusion"},{"issue":"02","key":"ref49","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/trf.13373","article-title":"Platelet components associated with adverse reactions: predictive value of mitochondrial DNA relative to biological response modifiers","volume":"56","author":"F Cognasse","year":"2016","journal-title":"Transfusion"},{"issue":"03","key":"ref50","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.thromres.2010.10.011","article-title":"Platelet CD40L at the interface of adaptive immunity","volume":"127","author":"B D Elzey","year":"2011","journal-title":"Thromb Res"},{"issue":"06","key":"ref51","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1160\/TH05-04-0270","article-title":"CD40-CD40L interactions in platelet activation","volume":"93","author":"G Dav\u00ec","year":"2005","journal-title":"Thromb 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Immunol"},{"issue":"02","key":"ref59","first-page":"109","article-title":"Improving platelet transfusion safety: biomedical and technical considerations","volume":"14","author":"O Garraud","year":"2016","journal-title":"Blood Transfus"},{"issue":"03","key":"ref60","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.hoc.2016.01.012","article-title":"Transfusion reactions","volume":"30","author":"W J Savage","year":"2016","journal-title":"Hematol Oncol Clin North Am"},{"issue":"03","key":"ref61","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cnc.2017.04.002","article-title":"Adverse reactions to transfusion of blood products and best practices for prevention","volume":"29","author":"S K Frazier","year":"2017","journal-title":"Crit Care Nurs Clin North Am"},{"issue":"04","key":"ref62","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/vox.12494","article-title":"Effect of storage time of platelet products on clinical outcomes after transfusion: a systematic review and meta-analyses","volume":"112","author":"A L Kreuger","year":"2017","journal-title":"Vox Sang"},{"issue":"03","key":"ref63","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/1089253212445488","article-title":"Blood product storage: does age really matter?","volume":"16","author":"S B Edelstein","year":"2012","journal-title":"Semin Cardiothorac Vasc Anesth"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1182\/asheducation-2011.1.470","article-title":"Immunomodulatory mediators in platelet transfusion reactions","volume":"2011","author":"C N Morrell","year":"2011","journal-title":"Hematology (Am Soc Hematol Educ Program)"},{"issue":"03","key":"ref65","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.tmrv.2018.04.001","article-title":"Platelet storage lesions: What more do we know now?","volume":"32","author":"M SY Ng","year":"2018","journal-title":"Transfus Med 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Feys","year":"2019","journal-title":"Transfus Med Rev"},{"issue":"01","key":"ref73","first-page":"152","article-title":"Do manual and automated processes with distinct additive solutions affect whole blood-derived platelet components differently?","volume":"11","author":"K A Nguyen","year":"2013","journal-title":"Blood Transfus"},{"issue":"04","key":"ref74","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1423-0410.2010.01353.x","article-title":"Function and activation state of platelets in vitro depend on apheresis modality","volume":"99","author":"S Macher","year":"2010","journal-title":"Vox Sang"},{"issue":"06","key":"ref75","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/trf.14109","article-title":"Analysis of platelet-derived extracellular vesicles in plateletpheresis concentrates: a multicenter study","volume":"57","author":"A 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