{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:34:24Z","timestamp":1780468464696,"version":"3.54.1"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Seit der Erstpublikation der peroralen endoskopischen Myotomie (POEM) durch Haruhiro Inoue et al. im Jahr 2008 in Japan haben sich verschiedene neuartige endoskopische Verfahren etabliert, welche nach iatrogener Schaffung eines submukosalen Tunnels als \u201eneuen Raum\u201c durchgef\u00fchrt werden 1. \u00dcber den k\u00fcnstlich gebildeten Zugangsweg in der Tela submucosa k\u00f6nnen unter sorgf\u00e4ltiger Schonung der obersten Schleimhautschicht Interventionen im Bereich der Muskelschicht von \u00d6sophagus und Magen durchgef\u00fchrt werden 2. Diese umfassen z.\u200aB. neben der Myotomie der \u00d6sophagusmuskulatur bei Achalasie (POEM) die Durchtrennung des Pylorus bei Gastroparese (Antropyloromyotomie, G-POEM). Weitere Einsatzgebiete sind die Spaltung des Zenker-Divertikels in POEM-Technik (\u201eZ-POEM\u201c) sowie die Entfernung subepithelialer Tumoren (STER: submukosale Tunnelung, endoskopische Resektion). Der langfristige Therapieerfolg (mit &gt;\u200a80\u200a% Ansprechen) dieser innovativen Verfahren ist v.\u200aa. bei der Achalasie mittlerweile durch kontrollierte Studien belegt 2\n          3\n          4\n          5\n          6.<\/jats:p>","DOI":"10.1055\/a-1351-5442","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:01:52Z","timestamp":1619827312000},"page":"608-612","source":"Crossref","is-referenced-by-count":1,"title":["Endoskopische Tunnelungsverfahren bei Achalasie und Gastroparese"],"prefix":"10.1055","volume":"146","author":[{"given":"Christopher Moritz","family":"Schad","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gastroenterologie, Gastroenterologische Tumortherapie und Diabetologie, Gemeinschaftsklinikum Mittelrhein, Kemperhof, Koblenz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Wildner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gastroenterologie, Hepatologie und Gastroenterologische Onkologie, Klinikum Bogenhausen, M\u00fcnchen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Gundling","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gastroenterologie, Gastroenterologische Tumortherapie und Diabetologie, Gemeinschaftsklinikum Mittelrhein, Kemperhof, Koblenz"},{"name":"Medizinische Klinik II: Gastroenterologie, Gastroenterologische Onkologie, Hepatologie, Diabetologie, Stoffwechsel, Infektiologie, Klinikum Bamberg, Bamberg"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,4,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1055\/s-0029-1244080","article-title":"Peroral endoscopic myotomy (POEM) for esophageal achalasia","volume":"42","author":"H Inoue","year":"2010","journal-title":"Endoscopy"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11938-016-0086-y","article-title":"POEM and Submucosal Tunneling","volume":"14","author":"Y B Werner","year":"2016","journal-title":"Curr Treat Options Gastroenterol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1056\/NEJMoa1905380","article-title":"Endoscopic or Surgical Myotomy in Patients with Idiopathic Achalasia","volume":"381","author":"Y B Werner","year":"2019","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1055\/s-0033-1343194","article-title":"Achalasia","volume":"138","author":"D von Renteln","year":"2013","journal-title":"Dtsch Med Wochenschr"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1053\/j.gastro.2008.07.022","article-title":"Achalasia: a new clinically revant classification by high-resolution manometry","volume":"135","author":"J E Pandolfino","year":"2008","journal-title":"Gastroenterol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/bjs.11049","article-title":"Meta-analysis Of clinical outcome after treatment for achalasia based on manometric subtypes","volume":"106","author":"C Andolfi","year":"2019","journal-title":"B J Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1055\/s-0043-112490","article-title":"Will Reflux Kill POEM?","volume":"49","author":"T R\u00f6sch","year":"2017","journal-title":"Endoscopy"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1053\/j.gastro.2008.12.047","article-title":"The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, from 1996 to 2006","volume":"136","author":"H K Jung","year":"2009","journal-title":"Gastroenterol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/ajg.2011.310","article-title":"Risk of gastroparesis in subjects with type 1 and 2 diabetes in the general population","volume":"107","author":"R S Choung","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"ref10","first-page":"889","article-title":"G-POEM in gastroparesis \u2013 another weapon in the armamentarium?","volume":"57","author":"F Gundling","year":"2019","journal-title":"Z Gastroenterol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1056\/NEJMcp062614","article-title":"Clinical practice. 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