{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:40:46Z","timestamp":1763037646188,"version":"3.37.3"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aktuelle Urol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Obwohl der Harntrakt mit Restharnbildung, Harnverhaltung, Pollakisurie, Polyurie, Nykturie, Detrusorstimulation, Detrusorhemmung, H\u00e4maturie, Dysurie und anderen Erscheinungen h\u00e4ufig den Schauplatz unerw\u00fcnschter Arzneimittelwirkungen darstellt, fehlt es an einer Gesamt\u00fcbersicht an Substanzen, die eine solche Harntraktnebenwirkung ausl\u00f6sen k\u00f6nnen und eine entsprechende Bewertung. Vorhandene Listen \u201epotenziell inad\u00e4quater Medikation\u201c fokussieren entweder auf eine pharmakologische Gruppe von Nebenwirkungen (\u201eanticholinergic burden score\u201c), eine Gruppe von Medikamenten bestimmter Indikation (LUTS-Forta) oder auf eine selektionierte Gruppe von Patienten (PRISKUS-Liste, beers-Liste).<\/jats:p><jats:p>Mit dem folgenden interdisziplin\u00e4ren Projekt aus der Arbeitsgruppe Uro-Geriatrie der Universit\u00e4t Witten\/Herdecke sollte diese L\u00fccke geschlossen werden. Es erfolgte eine Identifikation von Substanzen, die eine Harntraktnebenwirkung lt. diverser Datenbanken prinzipiell ausl\u00f6sen k\u00f6nnen, eine Kategorisierung der hierzu vorhandenen Literatur (Kasuistik, Fallsammlung, RCT, Metaanalyse) und eine strukturierte Bewertung des Risikos durch 33 Experten. Das Ergebnis stellt eine Liste von 235 Substanzen dar, die zu verschiedenen Harntraktnebenwirkungen f\u00fchren k\u00f6nnen. Diese Liste enth\u00e4lt einen die Nennung in Datenbanken bzw. deren Korrelat in der Literatur darstellenden \u201etheroretischen\u201c Punktwert, einen die klinische Realit\u00e4t abbildenden \u201epraktischen\u201c Punktwert, der die Expertenbewertung darstellt, und einen Summenscore \u2013 geordnet nach der Systematik der \u201eRoten Liste\u201c.<\/jats:p><jats:p>Erstmals w\u00e4re damit sowohl bei der Neuverordnung einer Substanz vor dem Hintergrund bestehender patientenseitiger Risiken eine Einsch\u00e4tzung dieses Wirkstoffes im Hinblick auf Harntraktnebenwirkungen m\u00f6glich; andersherum k\u00f6nnte die Durchsicht des Medikationsplanes bei Vorhandensein einer Harntraktfunktionsst\u00f6rung die Frage kl\u00e4ren, ob diese medikament\u00f6s (mit-) verursacht ist. Die Entwicklung des \u201eHarntraktnebenwirkungs-Rechners\u201c als \u201eApp\u201c ist geplant.<\/jats:p>","DOI":"10.1055\/a-1352-9370","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T23:34:40Z","timestamp":1622504080000},"page":"481-489","source":"Crossref","is-referenced-by-count":5,"title":["Unerw\u00fcnschte Arzneimittelwirkungen am Harntrakt \u2013 der Wittener Harntrakt-Nebenwirkungs-Score"],"prefix":"10.1055","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4960-7498","authenticated-orcid":false,"given":"Andreas","family":"Wiedemann","sequence":"additional","affiliation":[{"name":"Urologische Abteilung, Evangelisches Krankenhaus Witten"},{"name":"Lehrstuhl f\u00fcr Geriatrie, Universit\u00e4t Witten\/Herdecke"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vedat","family":"D\u00fcndar","sequence":"additional","affiliation":[{"name":"Lehrstuhl f\u00fcr Geriatrie, Universit\u00e4t Witten\/Herdecke"},{"name":"Praxis f\u00fcr Allgemeinmedizin, Dortmund"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Heese","sequence":"additional","affiliation":[{"name":"Urologische Abteilung, Evangelisches Krankenhaus Witten"},{"name":"Lehrstuhl f\u00fcr Geriatrie, Universit\u00e4t Witten\/Herdecke"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Leufgens","sequence":"additional","affiliation":[{"name":"Dr. Pfleger Arzneimittel GmbH, Bamberg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Wirz","sequence":"additional","affiliation":[{"name":"Dr. Pfleger Arzneimittel GmbH, Bamberg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Brauckmann","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Statistik, Chrestos Concept GmbH & Co. KG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-J\u00fcrgen","family":"Heppner","sequence":"additional","affiliation":[{"name":"Lehrstuhl f\u00fcr Geriatrie, Universit\u00e4t Witten\/Herdecke"},{"name":"Geriatrische Abteilung und Tagesklinik, Helios-Klinikum\nSchwelm"},{"name":"Institut f\u00fcr Biomedizin des Alterns der FAU Erlangen-\nN\u00fcrnberg"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/pds.4361","article-title":"Tamsulosin and the risk of dementia in older men with benign prostatic hyperplasia","volume":"27","author":"Y Duan","year":"2018","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/JU.0000000000000209","article-title":"alpha-Blocker and Risk of Dementia in Patients with Benign Prostatic Hyperplasia: A Nationwide Population Based Study Using the National Health Insurance Service Database","volume":"202","author":"B S Tae","year":"2019","journal-title":"J Urol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1056\/NEJMsa1103053","article-title":"Emergency hospitalizations for adverse drug events in older Americans","volume":"365","author":"D S Budnitz","year":"2011","journal-title":"N Engl J Med"},{"key":"ref4","first-page":"381","article-title":"Macrohematuria as the leading symptom in geriatric urology patients","volume":"58","author":"L Kuper","year":"2019","journal-title":"Urologe A"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neuropharm.2013.07.006","article-title":"Powerful inhibitory action of mu opioid receptors (MOR) on cholinergic interneuron excitability in the dorsal striatum","volume":"75","author":"G Ponterio","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2036.2007.03541.x","article-title":"Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin uptake inhibitors and non-steroidal anti-inflammatory drugs","volume":"27","author":"Y K Loke","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e8525","DOI":"10.1136\/bmj.e8525","article-title":"Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study","volume":"346","author":"F Lapi","year":"2013","journal-title":"BMJ"},{"key":"ref8","first-page":"e610","article-title":"Suspected Interaction of Cranberry Juice Extracts and Tacrolimus Serum Levels: A Case Report","volume":"8","author":"A A Dave","year":"2016","journal-title":"Cureus"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.2147\/DDDT.S199574","article-title":"Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6","volume":"13","author":"J Lee","year":"2019","journal-title":"Drug Des Devel Ther"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.sapharm.2018.06.002","article-title":"Factors associated with the use of potentially inappropriate medications by older adults in primary health care: An analysis comparing AGS Beers, EU(7)-PIM List , and Brazilian Consensus PIM criteria","volume":"15","author":"T A Almeida","year":"2019","journal-title":"Res Social Adm Pharm"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jen.2013.07.008","article-title":"Beers list: what's NOT on \u201etap\u201c for the older adult","volume":"39","author":"N S Donatelli","year":"2013","journal-title":"J Emerg Nurs"},{"key":"ref12","first-page":"2099","article-title":"The Beers List as an aid to prevent adverse drug reactions in elderly patients","volume":"149","author":"R W Vingerhoets","year":"2005","journal-title":"Ned Tijdschr Geneeskd"},{"key":"ref13","first-page":"1825","article-title":"Explicit criteria for determining inappropriate medication use in nursing home residents","volume":"151","author":"M H Beers","year":"1991","journal-title":"UCLA Division of Geriatric Medicine Arch Intern Med"},{"key":"ref14","first-page":"543","article-title":"Potentially inappropriate medications in the elderly: the PRISCUS list","volume":"107","author":"S Holt","year":"2010","journal-title":"Dtsch Arztebl Int"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/pds.3429","article-title":"Prescribing potentially inappropriate medication (PIM) in Germany's elderly as indicated by the PRISCUS list. 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