{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:49:54Z","timestamp":1767340194201,"version":"3.37.3"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background Penetrating keratoplasty (PK) gets more and more reserved to cases of increasing complexity. In such cases, ocular comorbidities may limit graft survival following PK. A major cause for graft failure is endothelial graft rejection. Suture removal is a known risk factor for graft rejection. Nevertheless, there is no evidence-based regimen for rejection prophylaxis following suture removal. Therefore, a survey of rejection prophylaxis was conducted at 7 German keratoplasty centres.<\/jats:p><jats:p>Objective The aim of the study was documentation of the variability of medicinal aftercare following suture removal in Germany.<\/jats:p><jats:p>Methods Seven German keratoplasty centres with the highest numbers for PK were selected. The centres were sent a survey consisting of half-open questions. The centres performed a mean of 140 PK in 2018. The return rate was 100%. The findings were tabulated.<\/jats:p><jats:p>Results All centres perform a double-running cross-stitch suture for standard PK, as well as a treatment for rejection prophylaxis with topical steroids after suture removal. There are differences in intensity (1\u200a\u2013\u200a5 times daily) and tapering (2\u200a\u2013\u200a20 weeks) of the topical steroids following suture removal. Two centres additionally use systemic steroids for a few days.<\/jats:p><jats:p>Discussion Rejection prophylaxis following PK is currently poorly standardised and not evidence-based. All included centres perform medical aftercare following suture removal. It is assumed that different treatment strategies show different cost-benefit ratios. In the face of the diversity, a systematic analysis is required to develop an optimised regimen for all patients.<\/jats:p>","DOI":"10.1055\/a-1353-6149","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T01:08:44Z","timestamp":1614301724000},"page":"591-597","source":"Crossref","is-referenced-by-count":1,"title":["Survey of Rejection Prophylaxis Following Suture Removal in Penetrating Keratoplasty in Germany"],"prefix":"10.1055","volume":"238","author":[{"given":"Sonja","family":"Heinzelmann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Freiburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"B\u00f6hringer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Freiburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip Christian","family":"Maier","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Freiburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9701-8204","authenticated-orcid":false,"given":"Berthold","family":"Seitz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum des Saarlandes UKS, Homburg (Saar), Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Cursiefen","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum K\u00f6ln, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna-Karina B.","family":"Maier","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Dietrich-Ntoukas","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd","family":"Geerling","sequence":"additional","affiliation":[{"name":"Augenklinik, Universit\u00e4tsklinikum D\u00fcsseldorf, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Viestenz","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik und Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Halle (Saale), Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Augenklinik und Poliklinik, Universit\u00e4tsmedizin Mainz, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Reinhard","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Freiburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,2,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0140-6736(12)60437-1","article-title":"Corneal transplantation","volume":"379","author":"D TH Tan","year":"2012","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1055\/a-1035-9442","article-title":"[Keratoplasty in Germany: Systematic Analysis of the Quality Reports of German Hospitals between 2006 and 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