{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T17:20:19Z","timestamp":1789320019980,"version":"build-2803163510"},"reference-count":77,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"name":"Deutsche Forschungsgemeinschaft (DFG) im Rahmen der Exzellenzstrategie innerhalb des Munich Cluster for Systems Neurology","award":["EXC 2145 SyNergy \u2013 ID 390857198"],"award-info":[{"award-number":["EXC 2145 SyNergy \u2013 ID 390857198"]}]},{"name":"Verum-Stiftung gef\u00f6rdert"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Das Down-Syndrom ist die h\u00e4ufigste genetische Ursache einer Intelligenzminderung. Da Menschen mit einem Down-Syndrom ein erh\u00f6htes Risiko aufweisen, an einer Alzheimer-Demenz zu erkranken, ist eine umfassende Untersuchung der kognitiven Funktionen indiziert, sowohl im jungen Erwachsenenalter (zur Erhebung des kognitiven Ausgangsniveaus) als auch im Verlauf zur Demenzdiagnostik. Das weite Spektrum an kognitiver Leistungsf\u00e4higkeit bei Menschen mit einem Down-Syndrom stellt eine diagnostische Herausforderung dar. Wir m\u00f6chten daher einen \u00dcberblick geben (1) \u00fcber die kognitive Entwicklung \u00fcber die Lebensspanne, (2) \u00fcber verschiedene m\u00f6gliche Ursachen kognitiver Ver\u00e4nderungen bei erwachsenen Menschen mit einem Down-Syndrom und (3) \u00fcber neuropsychologische Diagnostik und entsprechende Verfahren f\u00fcr den Erwachsenenbereich. Schlie\u00dflich geben wir, auf der Grundlage unserer Erfahrungen, (4) allgemeine Empfehlungen zur Untersuchung und Befundinterpretation bei Menschen mit Intelligenzminderung.<\/jats:p>","DOI":"10.1055\/a-1362-9868","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T23:44:02Z","timestamp":1614642242000},"page":"433-444","source":"Crossref","is-referenced-by-count":4,"title":["Kognition bei Down-Syndrom: Entwicklung \u00fcber die Lebensspanne und neuropsychologische Diagnostik im Erwachsenenalter"],"prefix":"10.1055","volume":"89","author":[{"given":"Sandra V.","family":"Loosli","sequence":"additional","affiliation":[{"name":"Neurologische Klinik und Poliklinik, Klinikum der Universit\u00e4t M\u00fcnchen, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Neurologische Klinik und Poliklinik, Klinikum der Universit\u00e4t M\u00fcnchen, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"N\u00fcbling","sequence":"additional","affiliation":[{"name":"Neurologische Klinik und Poliklinik, Klinikum der Universit\u00e4t M\u00fcnchen, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Wlasich","sequence":"additional","affiliation":[{"name":"Neurologische Klinik und Poliklinik, Klinikum der Universit\u00e4t M\u00fcnchen, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Prix","sequence":"additional","affiliation":[{"name":"Neurologische Klinik und Poliklinik, Klinikum der Universit\u00e4t M\u00fcnchen, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"},{"name":"Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen, Standort 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