{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:03:30Z","timestamp":1772823810184,"version":"3.50.1"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Canine African Trypanosomosis (CAT) is a rarely described disease with frequently lethal outcome. A 5-year-old female mongrel dog weighing 22 kg was presented in Austria due to unilateral uveitis, pancytopenia, and anorexia 4 months after return from a trip through Western Africa. Trypanosoma spp. flagellates were detected in a blood smear and identified as Trypanosoma congolense forest type by PCR. Initial treatment with imidocarb and miltefosine led to clinical improvement but only isometamidium chloride hydrochloride applied intramuscularly led to complete eradication of the pathogen from the dog\u2019s blood 4 months later.<\/jats:p>","DOI":"10.1055\/a-1377-1008","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T22:42:13Z","timestamp":1619476933000},"page":"142-147","source":"Crossref","is-referenced-by-count":3,"title":["Diagnosis and successful treatment of an Austrian dog infected with Trypanosoma congolense forest type"],"prefix":"10.1055","volume":"49","author":[{"given":"Michael","family":"Leschnik","sequence":"additional","affiliation":[{"name":"Department of Companion Animals and Horses, University of Veterinary Medicine Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Silbermayr","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Institute of Parasitology, University of Veterinary Medicine Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail","family":"Guija","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Central Laboratory, University of Veterinary Medicine Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Nell","sequence":"additional","affiliation":[{"name":"Department of Companion Animals and Horses, University of Veterinary Medicine Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,4,26]]},"reference":[{"key":"ref2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.vprsr.2016.03.003","article-title":"Trypanosoma evansi infection in a German shepherd dog \u2013 Apparent successful treatment using serial low dose diminazene aceturate","volume":"1\u20132","author":"P N Panigrahi","year":"2015","journal-title":"Vet Parasitol Regional 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Species spectrum and epidemiologic analysis of the cases diagnosed in 1995\/96","volume":"26","author":"B Glaser","year":"1998","journal-title":"Tierarztl Prax Ausg K"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1748-5827.2008.00663.x","article-title":"Canine African trypanosoma","volume":"49","author":"E M Hooft","year":"2008","journal-title":"J Small Anim Pract"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1748-5827.2007.00423.x","article-title":"First report of canine African trypanosomosis in the UK","volume":"48","author":"A G Gow","year":"2007","journal-title":"J Small Anim Pract"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1136\/vr.d888","article-title":"African Trypanosoma infection in a dog in France","volume":"168","author":"K Museux","year":"2011","journal-title":"Vet Rec"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1939-165X.2012.00454.x","article-title":"Canine Trypanosoma evansi infection introduced into Germany","volume":"41","author":"M Defontis","year":"2012","journal-title":"Vet Clin Pathol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1051\/parasite\/2012193239","article-title":"Atypical hyperpachymorph Trypanosoma (Nannomonas) congolense forest-type in a dog returning from Senegal","volume":"19","author":"M Desquesnes","year":"2012","journal-title":"Parasite"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"100353","DOI":"10.1016\/j.vprsr.2019.100353","article-title":"Canine vector-borne protozoa: Molecular and serological investigation for Leishmania spp., Trypanosoma spp., Babesia spp., and Hepatozoon spp. in dogs from Northern Algeria","volume":"19","author":"H Medkoura","year":"2020","journal-title":"Vet Parasitol Reg Studies and 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Rjeibi","year":"2015","journal-title":"Parasite"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.vetpar.2010.06.020","article-title":"Comparative haematological study of single and mixed infections of mongrel dogs with Trypanosoma congolene and Trypanosoma brucei brucei","volume":"173","author":"R C Ezeokonkwo","year":"2010","journal-title":"Vet Parasitol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.vetpar.2012.05.012","article-title":"Comparative serum biochemical changes in mongrel dogs following single and mixed infections of Trypanosoma congolense and Trypanosoma brucei brucei","volume":"190","author":"R C Ezeokonkwo","year":"2012","journal-title":"Vet Parasitol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S1473-3099(03)00834-X","article-title":"The challenge of Trypanosoma brucei gambiense sleeping sickness diagnosis outside Africa","volume":"3","author":"V Lejon","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1590\/0037-8682-1723-2013","article-title":"Serological cross-reactivity of Trypanosoma cruzi, Ehrlichia canis, Toxoplasma gondii, Neospora caninum and Babesia canis to Leishmania infantum chagasi tests in dogs","volume":"47","author":"M F Zanette","year":"2014","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1748-5827.1995.tb02835.x","article-title":"Trypanosoma congolense infection in two dogs","volume":"36","author":"S Harrus","year":"1995","journal-title":"J Small Anim Pract"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1093\/jac\/38.6.1041","article-title":"The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei","volume":"38","author":"S L Croft","year":"1996","journal-title":"J Antimicrobial Chemother"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.vetpar.2014.04.002","article-title":"The susceptibility of Trypanosoma congolense and Trypanosoma brucei to isometamidium chloride and its synthetic impurities","volume":"203","author":"A Sahin","year":"2014","journal-title":"Vet Parasitol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1550-7408.1979.tb04215.x","article-title":"Curative effects of the antipiroplasms amicarbalide and imidocarb on Trypanosoma brucei infection in mice","volume":"26","author":"H C Nathan","year":"1979","journal-title":"J Protozool"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0001-706X(96)00628-6","article-title":"Efficacy of anticancer alkylophosphocholines in Trypanosoma brucei subspecies","volume":"64","author":"S M Konstantinov","year":"1997","journal-title":"Acta 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Heimtiere"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1377-1008.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T22:45:42Z","timestamp":1619477142000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1377-1008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":40,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2021,4,26]]},"published-print":{"date-parts":[[2021,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1377-1008","relation":{},"ISSN":["1434-1239","2567-5842"],"issn-type":[{"value":"1434-1239","type":"print"},{"value":"2567-5842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}