{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T13:20:46Z","timestamp":1648732846211},"reference-count":13,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2021,3]]},"abstract":"Zusammenfassung<\/jats:title>\n Einleitung\u2002Die Tuberkulose ist eine oft untersch\u00e4tzte Infektionskrankheit, welche auch nach jahrelanger Latenz reaktiviert werden kann. Sowohl die prim\u00e4re als auch die postprim\u00e4re Form manifestieren sich am h\u00e4ufigsten pulmonal, jedoch kann auch jedes andere Organ befallen werden.<\/jats:p>\n Anamnese\u2002Eine 95-j\u00e4hrige Patientin wurde zur Abkl\u00e4rung einer lokal begrenzten, schmerzhaften Schwellung des rechten Fu\u00dfes aufgenommen. Trotz des fortgeschrittenen Alters bestanden keine Vorerkrankungen.<\/jats:p>\n Untersuchung und Diagnose\u2002Klinisch bestand am rechten Fu\u00dfr\u00fccken eine 5\u200acm gro\u00dfe fluktuierende hyper\u00e4mische Schwellung ohne Fistelung. Radiologisch zeigte sich eine komplette Destruktion regul\u00e4rer Strukturen vom Bereich des rechten oberen Sprunggelenks bis zu den Basen der Ossa metatarsalia.<\/jats:p>\n Therapie und Verlauf\u2002Intraoperativ stellte sich der Befund als Abszess dar, aus welchem kulturell der Nachweis von Mycobacterium tuberculosis gelang. In der Magnetresonanztomografie konnte eine Osteomyelitis nicht ausgeschlossen werden. Die Dauer der antituberkul\u00f6sen Standardtherapie wurde dementsprechend auf insgesamt 9 Monate festgelegt.<\/jats:p>\n Folgerung\u2002Bei unklaren Infektionen sollte gerade bei Patienten in der Immunseneszenz immer auch die M\u00f6glichkeit einer prim\u00e4ren oder postprim\u00e4ren Tuberkulosemanifestation bedacht werden.<\/jats:p>","DOI":"10.1055\/a-1377-4860","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T23:32:23Z","timestamp":1616110343000},"page":"399-402","source":"Crossref","is-referenced-by-count":0,"title":["Ungew\u00f6hnliche Sp\u00e4tmanifestation einer reaktivierten Tuberkulose in der Immunseneszenz nach 9 Dekaden Latenz"],"prefix":"10.1055","volume":"146","author":[{"given":"Jonas","family":"Fr\u00fch","sequence":"additional","affiliation":[{"name":"Klinikum W\u00fcrzburg Mitte, Abteilung f\u00fcr Tropenmedizin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"August","family":"Stich","sequence":"additional","affiliation":[{"name":"Klinikum W\u00fcrzburg Mitte, Abteilung f\u00fcr Tropenmedizin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Klinikum W\u00fcrzburg Mitte, Abteilung f\u00fcr Tropenmedizin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"ref1","isbn-type":"print","volume-title":"Global tuberculosis report 2019","author":"World Health Organization","year":"2019","ISBN":"http:\/\/id.crossref.org\/isbn\/9789241565714"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.ccm.2007.07.004","article-title":"Tuberculosis and Nontuberculous Mycobacterial Infections in Older Adults","volume":"28","author":"N W Schluger","year":"2007","journal-title":"Clin Chest Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.idc.2010.04.011","article-title":"Tuberculosis in the Global Aging Population","volume":"24","author":"T Mori","year":"2010","journal-title":"Infect Dis Clin North Am"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1086\/322671","article-title":"Tuberculosis and Aging: A Global Health Problem","volume":"33","author":"S Rajagopalan","year":"2001","journal-title":"Clin Infect Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/1876326X01206010073","article-title":"The Influence of Increasing Age on Susceptibility of the Elderly to Tuberculosis","volume":"6","author":"S-H Wang","year":"2012","journal-title":"Open Longev Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1385\/IR:36:1:221","article-title":"Age-Dependent Alterations of the T Cell Repertoire and Functional Diversity of T Cells of the Aged","volume":"36","author":"A N Vallejo","year":"2006","journal-title":"J Immunol Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.clindermatol.2006.05.005","article-title":"Cutaneous tuberculosis","volume":"25","author":"F G Bravo","year":"2007","journal-title":"Clin Dermatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e28815","DOI":"10.1371\/journal.pone.0028815","article-title":"Comparison of Quantitative Techniques including Xpert MTB\/RIF to Evaluate Mycobacterial Burden","volume":"6","author":"R N van Zyl-Smit","year":"2011","journal-title":"PLoS ONE"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2334-14-23","article-title":"Acute kidney injury due to anti-tuberculosis drugs: a five-year experience in an aging population","volume":"14","author":"C-H Chang","year":"2014","journal-title":"BMC Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.tube.2014.10.006","article-title":"Hepatotoxicity from antituberculous therapy in the elderly: A systematic review","volume":"95","author":"J D Hosford","year":"2015","journal-title":"Tuberculosis"},{"key":"ref11","first-page":"325","article-title":"S2k-Leitlinie: Tuberkulose im Erwachsenenalter: Eine Leitlinie zur Diagnostik und Therapie, einschlie\u00dflich Chemopr\u00e4vention und -prophylaxe des Deutschen Zentralkomitees zur Bek\u00e4mpfung der Tuberkulose e.\u200aV. im Auftrag der Deutschen Gesellschaft f\u00fcr Pneumologie und Beatmungsmedizin e.\u200aV. Pneumologie","volume":"71","author":"T Schaberg","year":"2017"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.25646\/6195","article-title":"Bericht zur Epidemiologie der Tuberkulose in Deutschland f\u00fcr 2018","author":"Robert-Koch-Institut R","year":"2019"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/emi.2016.10","article-title":"Updates on the risk factors for latent tuberculosis reactivation and their managements","volume":"5","author":"J-W Ai","year":"2016","journal-title":"Emerg microbes & infect"}],"container-title":["DMW - Deutsche Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1377-4860.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T06:01:13Z","timestamp":1616133673000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1377-4860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":13,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2021,3,18]]},"published-print":{"date-parts":[[2021,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1377-4860","relation":{},"ISSN":["0012-0472","1439-4413"],"issn-type":[{"value":"0012-0472","type":"print"},{"value":"1439-4413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}