{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:01:33Z","timestamp":1785207693027,"version":"3.55.0"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"Norgine Italia Srl","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background The Endocuff Vision device (Arc Medical Design Ltd., Leeds, UK) has been shown to increase mucosal exposure, and consequently adenoma detection rate (ADR), during colonoscopy. This nationwide multicenter study assessed possible benefits and harms of using Endocuff Vision in a fecal immunochemical test (FIT)-based screening program.<\/jats:p><jats:p>\n          Methods Patients undergoing colonoscopy after a FIT-positive test were randomized 1:1 to undergo Endocuff-assisted colonoscopy or standard colonoscopy, stratified by sex, age, and screening history. Primary outcome was ADR. Secondary outcomes were ADR stratified by endoscopists\u2019 ADR, advanced ADR (AADR), adenomas per colonoscopy (APC), withdrawal time, and adverse events.<\/jats:p><jats:p>\n          Results 1866 patients were enrolled across 13 centers. After exclusions, 1813 (mean age 60.1 years; male 53.8\u200a%) were randomized (908 Endocuff Vision, 905 standard colonoscopy). ADR was significantly higher in the Endocuff Vision arm (47.8\u200a% vs. 40.8\u200a%; relative risk [RR] 1.17, 95\u200a% confidence interval [CI] 1.06\u20131.30), with no differences between arms regarding size or morphology. When stratifying for endoscopists\u2019 ADR, only low detectors (ADR\u200a&lt;\u200a33.3\u200a%) showed a statistically significant ADR increase (Endocuff Vision 41.1\u200a% [95\u200a%CI 35.7\u201346.7] vs. standard colonoscopy 26.0\u200a% [95\u200a%CI 21.3\u201331.4]). AADR (24.8\u200a% vs. 20.5\u200a%, RR 1.21, 95\u200a%CI 1.02\u20131.43) and APC (0.94 vs. 0.77; P \u200a=\u200a0.001) were higher in the Endocuff Vision arm. Withdrawal time and adverse events were similar between arms. <\/jats:p><jats:p>\n          Conclusion Endocuff Vision increased ADR in a FIT-based screening program by improving examination of the whole colonic mucosa. Utility was highest among endoscopists with a low ADR.<\/jats:p>","DOI":"10.1055\/a-1379-6868","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T03:34:11Z","timestamp":1612236851000},"page":"138-147","source":"Crossref","is-referenced-by-count":34,"title":["Adenoma detection by Endocuff-assisted versus standard colonoscopy in an organized screening program: the \u201cItaVision\u201d randomized controlled trial"],"prefix":"10.1055","volume":"54","clinical-trial-number":[{"clinical-trial-number":"nct03612674","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Manuel","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Veneto Tumor Registry, Azienda Zero, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Hassan","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Nuovo Regina Margherita Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Battagello","sequence":"additional","affiliation":[{"name":"Veneto Tumor Registry, Azienda Zero, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Nuovo Regina Margherita Hospital, Rome, Italy"},{"name":"Department of Translational and Precision Medicine, \u201cSapienza\u201d University of Rome, Italy"},{"name":"Gastroenterology and Digestive Endoscopy Unit, Ospedale dei Castelli (N.O.C.), ASL Roma 6, Ariccia, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Pantalena","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Cazzavillan Hospital, ULSS 8 Berica, Arzignano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmarco","family":"Bulighin","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Fracastoro Hospital, ULSS 9 Scaligera, San Bonifacio, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Alicante","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, ASST-Crema, Maggiore Hospital, Crema, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Meggiato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Rovigo General Hospital, ULSS 5 Polesana, Rovigo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Rosa-Rizzotto","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, St. Anthony Hospital, Azienda Ospedale-Universit\u00e0, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Iacopini","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Ospedale dei Castelli (N.O.C.), ASL Roma 6, Ariccia, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Luigiano","sequence":"additional","affiliation":[{"name":"Unit of Digestive Endoscopy, ASST Santi Paolo e Carlo, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3064-1269","authenticated-orcid":false,"given":"Fabio","family":"Monica","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Cattinara University Hospital, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arrigo","family":"Arrigoni","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, University Hospital Citt\u00e0 della Salute e della Scienza, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastianello","family":"German\u00e0","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, San Martino Hospital, ULSS 1 Dolomiti, Belluno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Valiante","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Santa Maria del Prato Hospital, ULSS 1 Dolomiti, Feltre, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Mallardi","sequence":"additional","affiliation":[{"name":"Screening Unit, Institute for Cancer Research, Prevention and Oncological Network (ISPRO), Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Senore","sequence":"additional","affiliation":[{"name":"Epidemiology and Screening Unit \u2013 CPO, University Hospital Citt\u00e0 della Salute e della Scienza, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Grazzini","sequence":"additional","affiliation":[{"name":"Screening Unit, Institute for Cancer Research, Prevention and Oncological Network (ISPRO), Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Mantellini","sequence":"additional","affiliation":[{"name":"Screening Unit, Institute for Cancer Research, Prevention and Oncological Network (ISPRO), Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and the ItaVision Working Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"issue":"S 03","key":"ref1","first-page":"SE151","article-title":"European guidelines for quality assurance in colorectal cancer screening and diagnosis. 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