{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:40:29Z","timestamp":1763037629522},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Handchir Mikrochir Plast Chir"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die nekrotisierende Fasziitis (NF) ist eine schwerwiegende Infektion, die sich entlang der Faszien auf das subkutane Fett und die dar\u00fcber liegenden Weichteile, die Haut und schlie\u00dflich die Muskulatur ausbreitet und unbehandelt schnell zu septischem Schock und Tod f\u00fchrt. Um eine massive systemische Ausbreitung des infekti\u00f6sen Prozesses zu vermeiden, ist schon bei Verdacht ein sofortiges und umfassendes radikales chirurgisches Debridement des nekrotischen Gewebes erforderlich, erg\u00e4nzt durch eine kalkulierte intraven\u00f6se antibiotische Therapie. Die Mortalit\u00e4t ist trotzdem mit 20\u201340\u2005% anhaltend hoch. Aufgrund des Fehlens spezifischer klinischer Merkmale im Anfangsstadium der Krankheit wird sie h\u00e4ufig untersch\u00e4tzt oder mit einem lokalen Infekt oder Abszess verwechselt. In 85\u2013100\u2005% der F\u00e4lle kommt es zu einer versp\u00e4teten Diagnose mit dem Verstreichen kostbarer Zeit.<\/jats:p><jats:p>Das Ziel dieser \u00dcbersichtsarbeit ist es, die f\u00fcr die Diagnose relevanten klinischen und laborchemischen Parameter sowie die wesentlichen therapeutischen Schritte zusammenzufassen.<\/jats:p>","DOI":"10.1055\/a-1381-8077","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T22:34:27Z","timestamp":1623882867000},"page":"312-319","source":"Crossref","is-referenced-by-count":7,"title":["Die nekrotisierende Fasziitis"],"prefix":"10.1055","volume":"53","author":[{"given":"Maxi","family":"von Glinski","sequence":"additional","affiliation":[{"name":"Berufsgenossenschaftliches Universit\u00e4tsklinikum Bergmannsheil; Universit\u00e4tsklinik f\u00fcr Plastische Chirurgie und Handchirurgie, Schwerbrandverletztenzentrum, Sarkomzentrum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehran","family":"Dadras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Wallner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes Maximilian","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Behr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Lehnhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"ref1","first-page":"416","article-title":"Necrotizing fasciitis","volume":"18","author":"B Wilson","year":"1952","journal-title":"Am Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/s0140-6736(94)91956-9","article-title":"Hippocrates on necrotising fasciitis","volume":"344","author":"V Descamps","year":"1994","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1128\/JCM.01626-07","article-title":"Clinical and epidemiological aspects of invasive Streptococcus pyogenes infections in Denmark during 2003 and 2004","volume":"46","author":"B Luca-Harari","year":"2008","journal-title":"J Clin Microbiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.2106\/00004623-200308000-00005","article-title":"Necrotizing fasciitis: clinical presentation, microbiology, and determinants of mortality","volume":"85","author":"C H Wong","year":"2003","journal-title":"J Bone Joint Surg Am"},{"key":"ref6","first-page":"397","article-title":"Aggressive surgical management of necrotizing fasciitis serves to decrease mortality: a retrospective study","volume":"64","author":"B D Bilton","year":"1998","journal-title":"Am Surg"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1001\/archderm.138.7.893","article-title":"Necrotizing fasciitis: report of 39 pediatric cases","volume":"138","author":"A Fustes-Morales","year":"2002","journal-title":"Arch Dermatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1177\/000313480206800201","article-title":"Necrotizing fasciitis: a fourteen-year retrospective study of 163 consecutive patients","volume":"68","author":"B J Childers","year":"2002","journal-title":"Am Surg"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1097\/00001432-199804000-00005","article-title":"Skin and soft tissue infection: necrotizing fasciitis","volume":"11","author":"D E Low","year":"1998","journal-title":"Curr Opin Infect Dis"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1007\/BF02554904","article-title":"Jean-Alfred Fournier 1832\u20131914. 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