{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T22:48:35Z","timestamp":1709160515348},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Handchir Mikrochir Plast Chir."],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Unter der selten auftretenden erworbenen Meth\u00e4moglobin\u00e4mie ist die Prilocain-induzierte \u00e4tiologisch gesehen eine Rarit\u00e4t. Der folgende Fallbericht behandelt sie als potenziell gef\u00e4hrliche Komplikation nach Liposuktion mit Prilocain.<\/jats:p><jats:p>Eine junge Patientin stellte sich nach pr\u00e4synkopalem Sturzereignis mit blassem Hautkolorit, immobilisierendem Handgelenksschmerz und Platzwunde am Kinn in der interdisziplin\u00e4ren Notaufnahme vor. Etwa 12 Stunden zuvor sei bei der Patientin ambulant in Regionalan\u00e4sthesie eine Liposuktion der unteren Extremit\u00e4t durchgef\u00fchrt worden. Dabei sei ein gr\u00f6\u00dferes Volumen einer Tumeszenzl\u00f6sung, bestehend u.\u2009a. aus Prilocain, in das Gewebe infiltriert worden.<\/jats:p><jats:p>Bei initialer Vorstellung wurden ein normwertiger Blutdruck, eine leichte Tachykardie, eine periphere Sauerstoffs\u00e4ttigung von 90\u2009% bei Raumluft gemessen und klinisch fielen ein reduzierter Allgemeinzustand und eine Lippenzyanose auf. Die Liposuktionszonen waren unauff\u00e4llig.<\/jats:p><jats:p>Die erste arterielle Blutgasanalyse zeigte einen erh\u00f6hten Meth\u00e4moglobin(Met-Hb)anteil von 10,9\u2009%. Konventionell-radiologisch lie\u00df sich eine minimal dislozierte distale Radiusfraktur nachweisen. Unter Sauerstofftherapie fiel das Met-Hb innerhalb von 4 Stunden auf 6\u2009%, die Lippenzyanose war r\u00fcckl\u00e4ufig, die Vitalparameter stabilisierten sich, die Platzwunde wurde mittels prim\u00e4rer Wundnaht versorgt und es erfolgte eine Ruhigstellung des Handgelenks. Nach 12-st\u00fcndigem Aufenthalt erfolgte die Entlassung bei gebessertem Allgemeinzustand. Sechs Wochen posttraumatisch zeigte sich eine Konsolidierung der Fraktur und funktionell-\u00e4sthetisch regelrechte Wundheilung des Kinns. Wir m\u00f6chten f\u00fcr die Differenzialdiagnose einer Prilocain-induzierten Meth\u00e4moglobin\u00e4mie nach Liposuktion mit Tumeszenzl\u00f6sung sensibilisieren und im Allgemeinen die Verwendung von Prilocain diskutieren.<\/jats:p>","DOI":"10.1055\/a-1382-1628","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T23:29:21Z","timestamp":1618615761000},"page":"407-411","source":"Crossref","is-referenced-by-count":2,"title":["Folgenreiche Liposuktion\u00a0\u2013\u00a0was man im Umgang mit Prilocain beachten sollte"],"prefix":"10.1055","volume":"53","author":[{"given":"Julius Michael","family":"Mayer","sequence":"first","affiliation":[{"name":"Spital Thurgau AG, Hand- und Plastische Chirurgie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl Ferdinand","family":"Capellen","sequence":"first","affiliation":[{"name":"Spital Thurgau AG, Klinik f\u00fcr Innere Medizin \u2013 Kantonsspital M\u00fcnsterlingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Holzbach","sequence":"additional","affiliation":[{"name":"Spital Thurgau AG, Hand- und Plastische Chirurgie"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"key":"ref3","first-page":"920","volume-title":"Onkologie und H\u00e4matologie","author":"J Edward","year":"2012"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1055\/s-0029-1224778","article-title":"Schwere Meth\u00e4moglobin\u00e4mie\u00a0\u2013\u00a0Diagnostik, Therapie und Pathophysiologie am Beispiel eines Falles","volume":"44","author":"M Moos","year":"2009","journal-title":"Anasthesiol Intensivmed Notfallmed Schmerzther"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1172\/jci102067","article-title":"Congenital methemoglobinemia. 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prilocaine induced methemoglobinemia","volume":"14","author":"E Kilicli","year":"2014","journal-title":"Turk J Emerg Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"282347","DOI":"10.1155\/2015\/282347","article-title":"A case report of prilocaine-induced methemoglobinemia after liposuction procedure","volume":"2015","author":"B Yildirim","year":"2015","journal-title":"Case Rep Emerg Med"}],"container-title":["Handchirurgie \u00b7 Mikrochirurgie \u00b7 Plastische Chirurgie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1382-1628.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T22:34:54Z","timestamp":1628548494000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1382-1628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,16]]},"references-count":18,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2021,8,9]]},"published-print":{"date-parts":[[2021,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1382-1628","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0722-1819","1439-3980"],"issn-type":[{"value":"0722-1819","type":"print"},{"value":"1439-3980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,16]]}}}