{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:19:06Z","timestamp":1791652746525,"version":"4.3.4"},"reference-count":45,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypertension is a chronic disease and a global health problem. Due to its high prevalence, it constitutes the most important risk factor for cardiovascular disease. Fruit peels from Passiflora edulis fo. flavicarpa are rich in bioactive natural compounds that may have action in hypertension. This study aimed to perform a fingerprinting analysis of Passiflora edulis fruit peel extract and evaluate its actions on the cardiovascular system in an in vivo model. The extract was obtained from the dried and powdered fruit peels of Passiflora edulis. Glycoside flavonoids were identified in the extract by HPLC-ESI-MSn. The extract showed a significant hypotensive effect after 28\u00a0days of treatment and improved vascular function in the mesenteric artery. This effect was verified by decreased vascular hypercontractility and increased vasorelaxant in response to sodium nitroprusside and acetylcholine. There was also a decrease in\n\t\t\t\t\tendothelial dysfunction, which can be attributed to nitric oxide\u02bcs increased bioavailability. Thus, we hypothesize that all these effects contributed to a reduction in peripheral vascular resistance, leading to a significant hypotensive effect. These results are novel for fruit peels from P.\u00a0edulis. Also, there was a decrease in plasma and cardiac malondialdehyde levels and an increase in glutathione, suggesting a reduction in oxidative stress, as well as an increase of anti-inflammatory cytokines such as IL-10 in the plasma. This study demonstrated that the extract can be a new source of raw material to be applied as food or medicine adjuvant for treating hypertension.<\/jats:p>","DOI":"10.1055\/a-1385-8863","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T22:47:30Z","timestamp":1628030850000},"page":"356-366","source":"Crossref","is-referenced-by-count":11,"title":["Cardiovascular Effects Induced by Fruit Peels from Passiflora edulis in Hypertensive Rats and Fingerprint Analysis by HPLC-ESI-MSn spectrometry"],"prefix":"10.1055","volume":"88","author":[{"given":"B\u00e1rbara","family":"Cabral","sequence":"additional","affiliation":[{"name":"Research Group on Bioactive Natural Products (PNBio), Laboratory of Pharmacognosy, Postgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tays Amanda Felisberto","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Silva","family":"Abreu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0840-8097","authenticated-orcid":false,"given":"Anderson Wilbur Lopes","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Pharmacology, Center for Biosciences, Federal University of Rio Grande do Norte, Natal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima de Lourdes Assun\u00e7\u00e3o Ara\u00fajo","family":"de Azevedo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francker Duarte","family":"de Castro","sequence":"additional","affiliation":[{"name":"Research Group on Bioactive Natural Products (PNBio), Laboratory of Pharmacognosy, Postgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josean Fechine","family":"Tavares","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerlane Coelho Bernardo","family":"Guerra","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Pharmacology, Center for Biosciences, Federal University of Rio Grande do Norte, Natal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Augusto","family":"de Rezende","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isac Almeida","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2768-0793","authenticated-orcid":false,"given":"Silvana Maria","family":"Zucolotto","sequence":"additional","affiliation":[{"name":"Research Group on Bioactive Natural Products (PNBio), Laboratory of Pharmacognosy, Postgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/S0140-6736(12)61766-8","article-title":"A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990\u20132010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"S S Lim","year":"2012","journal-title":"Lancet"},{"key":"ref2","first-page":"e29","article-title":"Heart disease and stroke statistics\u20132015: update a report from the American Heart Association","volume":"131","author":"D Mozaffarian","year":"2015","journal-title":"Circulation"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1161\/HYPERTENSIONAHA.114.03575","article-title":"Endothelial dysfunction and hypertension","volume":"64","author":"R P 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