{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:13Z","timestamp":1740126853386,"version":"3.37.3"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background To report the efficacy of ab externo canaloplasty by exclusively using only a nonabsorbable suture as a standalone operation or combined with phacoemulsification in terms of mean intraocular pressure (IOP), medication reduction, and intra- and postoperative complication rates as well as additional glaucoma surgery.<\/jats:p><jats:p>\n          Patients and Methods Forty-eight patients with primary open-angle glaucoma (POAG) and 50 eyes were divided into two groups according to the operation performed (Group A canaloplasty, n\u2009=\u200934 and Group B canaloplasty combined with phaco, n\u2009=\u200916), respectively. The success criteria were evaluated between three IOP ranges: a) IOP \u2264\u200916\u2009mmHg, b)\u00a0\u2264\u200918\u2009mmHg, and c) \u2264\u200921\u2009mmHg. Complete success was considered the percentage of eyes reaching these goals with no medication and qualified success with or without medication. Groups A and B were compared with the Kaplan-Meier test. Mean IOP and medication reduction as well as additional glaucoma surgery were also evaluated. The follow-up time was 6 months. Statistical importance was given at p\u2009&lt;\u20090.05.<\/jats:p><jats:p>\n          Results Fail rate and intraoperative conversion of canaloplasty to other surgery (trabeculotomy due to extensive cheese-wiring) accounted for 12% (6 eyes), while a mandatory usage of the iTrack 250A microcatheter to successfully overcome intracanalicular bridging of the Schlemm\u02bcs canal accounted for 20% (10 eyes). The most common early postoperative complications in both groups were hyphema, cheese wiring, and transient IOP rising. The mean IOP in Group A reduced from 23.67\u2009\u00b1\u20096.06\u2009mmHg to 13.35\u2009\u00b1\u20094.23\u2009mmHg and in Group B, it reduced from 23.55\u2009\u00b1\u20096.19\u2009mmHg to 12.75\u2009\u00b1\u20091.5\u2009mmHg at 6\u00a0months (p\u2009&lt;\u20090.001). Group A\u02bcs absolute success rates accounted for a)\u00a044%, b)\u00a047.1%, and c) 52.9% in comparison to Group B [a) 50%, b)\u00a050%, and c) 56.3%] at 6 months (p\u2009&lt;\u20090.05). Qualified success with or without medication showed no statistical differences between the groups. The mean medication reduction was significantly lower (p\u2009&lt;\u20090.001) in both groups (Group A from baseline\n\t\t\t\t\t3.2\u2009\u00b1\u20091.23 to 0.95\u2009\u00b1\u20091.35 and Group B from 3.12\u2009\u00b1\u20090.88 to 1.12\u2009\u00b1\u20090.75 at 6 months, respectively). Five eyes (10%) required additional glaucoma surgery.<\/jats:p><jats:p>\n          Conclusions Ab externo canaloplasty by exclusively using only a nonabsorbable suture as a standalone operation or combined with phacoemulsification seems to lower the mean IOP and medication sufficiently. However, they pose a greater surgical challenge and intraoperative complication rate. Additional glaucoma surgery or medication following both procedures may be necessary to achieve an optimal target IOP.<\/jats:p>","DOI":"10.1055\/a-1386-3170","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T23:22:29Z","timestamp":1618442549000},"page":"380-390","source":"Crossref","is-referenced-by-count":1,"title":["The Efficacy of Ab Externo Canaloplasty by Using a Nonabsorbable Suture and No Viscoelastics; IOP Results, Intraoperative and Early Complication Rates within 6-Month Follow-Up Period"],"prefix":"10.1055","volume":"238","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4420-4625","authenticated-orcid":false,"given":"Iraklis","family":"Vastardis","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Sankt-Johannes-Hospital Dortmund, Dortmund, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Fili","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Sankt-Johannes-Hospital Dortmund, Dortmund, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Perdikakis","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Sankt-Johannes-Hospital Dortmund, Dortmund, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalliopi","family":"Kontopoulou","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Sankt-Johannes-Hospital Dortmund, Dortmund, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zisis","family":"Gatzioufas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsspital Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Kohlhaas","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Sankt-Johannes-Hospital Dortmund, Dortmund, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","article-title":"Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial","volume":"120","author":"A Heijl","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/archopht.120.6.701","article-title":"The Ocular Hypertension Treatment study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma","volume":"120","author":"M A Kass","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/S0161-6420(01)00873-9","article-title":"CIGTS Study Group. 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Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1386-3170.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T22:52:44Z","timestamp":1619823164000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1386-3170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":20,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2021,4,30]]},"published-print":{"date-parts":[[2021,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1386-3170","relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"type":"print","value":"0023-2165"},{"type":"electronic","value":"1439-3999"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}