{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:28:37Z","timestamp":1784867317779,"version":"3.55.0"},"reference-count":7,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002Crush cytology is a simple and rapid method used for diagnosis of central nervous system lesions. We have evaluated the diagnostic accuracy of crush cytology for gastrointestinal tract lesions.<\/jats:p><jats:p>\n          Patients and methods\u2002This was a prospective, cross-sectional, single center study, conducted on the patients who had suspected malignant lesions between August 2018 and March 2020. The crush cytologic diagnoses were correlated with histology to determine the diagnostic accuracy.<\/jats:p><jats:p>\n          Results\u2002During the period of interest, a total of 451 patients (26.4\u200a% esophagus &amp; GE junction, 16.6\u200a% stomach, 5.9\u200a% ampulla &amp; duodenum, and 50.9\u200a% colorectal) had a suspected malignant lesion on endoscopic examination. Histology confirmed 92.9\u200a% cases as malignant lesions and 7.1\u200a% as nonmalignant. On crush cytology, 84.5\u200a% were positive for malignancy, 8.9\u200a% were negative for malignancy and 6.6\u200a% were reported as suspicious for malignancy. The overall sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of crush cytology were 97.3\u200a%, 90\u200a%, 99.2\u200a%, 72.5\u200a% and 96.9\u200a%, respectively. <\/jats:p><jats:p>\n          Conclusions\u2002Crush cytology is a highly sensitive, specific, rapid and cost effective technique to diagnose gastrointestinal malignancies in endoscopically suspected malignant lesions. However, it cannot entirely substitute histopathological examination for definite tumor typing, grading, confirming invasion and in cases in which cytology is suspicious. Crush cytology is an added asset to the histology to maximize diagnostic accuracy and accelerating decision making for the management of lesions.<\/jats:p>","DOI":"10.1055\/a-1388-6479","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:17:52Z","timestamp":1619137072000},"page":"E735-E740","source":"Crossref","is-referenced-by-count":4,"title":["Crush cytology: an expeditious diagnostic tool for gastrointestinal tract malignancy"],"prefix":"10.1055","volume":"09","author":[{"given":"Pankaj","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Endoscopy & Endosonography, Surat Institute of Digestive Sciences (SIDS), Surat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Kabrawala","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Surat Institute of Digestive Sciences (SIDS), Surat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chintan","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Endoscopy & Endosonography, Surat Institute of Digestive Sciences (SIDS), Surat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Pathology, Surat Institute of Digestive Sciences (SIDS), Surat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Surat Institute of Digestive Sciences (SIDS), Surat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhash","family":"Nandwani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Surat Institute of Digestive Sciences (SIDS), Surat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parika","family":"Kalra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Surat Institute of Digestive Sciences (SIDS), Surat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritesh","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Surat Institute of Digestive Sciences (SIDS), Surat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisharg","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Surat Institute of Digestive Sciences (SIDS), Surat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Parekh","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Surat Institute of Digestive Sciences (SIDS), Surat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global Cancer Statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"F Bray","year":"2018","journal-title":"Ca Cancer J Clin"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000487470","article-title":"Narrow-band imaging: clinical application in gastrointestinal endoscopy","volume":"26","author":"S Barbeiro","year":"2018","journal-title":"GE Port J Gastroenterol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000325438","article-title":"Comparison of cytohistologic techniques in diagnosis of gastroesophageal malignacy","volume":"52","author":"M Batra","year":"2006","journal-title":"Acta Cytologica"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"681","DOI":"10.4103\/0973-1482.163738","article-title":"Diagnostic accuracy of endoscopic brush cytology in malignancies of upper gastrointestinal tract: A prospective study of 251 patients in North India","volume":"12","author":"S Kaur","year":"2016","journal-title":"J Cancer Res Ther"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4103\/jnrp.jnrp_222_18","article-title":"Is crush cytology of central nervous system lesions relevant in surgical practice today?","volume":"10","author":"K K Yadav","year":"2019","journal-title":"J Neurosci Rural Pract"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000487628","article-title":"The Role of crush cytology in the diagnosis of large-intestine lesions with correlation on histopathology","volume":"62","author":"C Gv","year":"2018","journal-title":"Acta Cytol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/dc.23699","article-title":"Utility of touch imprint cytology in the preoperative diagnosis of malignancy in low resource setting","volume":"45","author":"A K Adhya","year":"2017","journal-title":"Diagn Cytopathol"}],"container-title":["Endoscopy International Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1388-6479.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:21:49Z","timestamp":1619137309000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1388-6479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,22]]},"references-count":7,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2021,4,22]]},"published-print":{"date-parts":[[2021,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1388-6479","relation":{},"ISSN":["2364-3722","2196-9736"],"issn-type":[{"value":"2364-3722","type":"print"},{"value":"2196-9736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,22]]}}}