{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T22:29:28Z","timestamp":1675636168355},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Anamnese und klinischer Befund\u2002Ein 68 Jahre alter m\u00e4nnlicher Patient mit einer Psoriasis und einem bull\u00f6sen Pemphigoid als Grunderkrankungen entwickelte unter einer l\u00e4nger anhaltenden, h\u00f6her dosierten immunsuppressiven Therapie mit Methylprednisolon eine klinische Beschwerdesymptomatik mit trockenem Reizhusten, einer progredienten Dyspnoe und Fieber.<\/jats:p><jats:p>\n          Untersuchungen und Diagnose\u2002Im CT-Thorax zeigten sich beidseitige Milchglasinfiltrate. Nach Ausschluss von COVID-19 wurde eine Pneumocystis-jirovecii-Pneumonie (PCP) nachgewiesen.<\/jats:p><jats:p>\n          Therapie und Verlauf\u2002Es wurde daraufhin eine entsprechende hochdosierte Therapie mit Trimethoprim-Sulfamethoxazol zeitnah eingeleitet. Gleichwohl entwickelte sich ein komplizierter Verlauf mit bakterieller Superinfektion und pulmonaler Aspergillose sowie ARDS.\u200a<\/jats:p><jats:p>\n          Diskussion und Folgerung\u2002In Abgrenzung zu COVID-19 werden der typische Verlauf sowie Diagnostik und Therapie der Pneumocystis-jirovecii-Pneumonie diskutiert. Es wird insbesondere darauf abgehoben, dass auch in einer Pandemiesituation nicht alle Milchglasinfiltrate im CT-Thorax-Bild auf COVID-19 zur\u00fcckzuf\u00fchren sind. M\u00f6gliche Differenzialdiagnosen sollten stets bedacht und in der Diagnostik ber\u00fccksichtigt werden.<\/jats:p>","DOI":"10.1055\/a-1391-4403","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:01:52Z","timestamp":1619827312000},"page":"603-607","source":"Crossref","is-referenced-by-count":3,"title":["Nicht alles Milchglas ist COVID-19 \u2013 Pneumocystis-jirovecii-Pneumonie als Differenzialdiagnose"],"prefix":"10.1055","volume":"146","author":[{"given":"Meike","family":"Sch\u00fc\u00dfler","sequence":"first","affiliation":[{"name":"Bundeswehrzentralkrankenhaus Koblenz, Abteilung I \u2013 Klinik\u00a0f\u00fcr Innere Medizin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Bundeswehrzentralkrankenhaus Koblenz, Abteilung I \u2013 Klinik\u00a0f\u00fcr Innere Medizin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Rauschning","sequence":"additional","affiliation":[{"name":"Bundeswehrzentralkrankenhaus Koblenz, Abteilung I \u2013 Klinik\u00a0f\u00fcr Innere Medizin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,4,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40779-020-0233-6","article-title":"A rapid advice guidline for the diagnosis and\u00a0treatment of 2019 coronavirus (2019-nCoV) infected pneumonia (standard version)","volume":"7","author":"Y Jin","year":"2020","journal-title":"Military Medical Research"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1473-3099(20)30086-4","article-title":"Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study","volume":"20","author":"H Shi","year":"2020","journal-title":"Lancet Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jinf.2020.02.017","article-title":"Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2","volume":"80","author":"X Yu-Huan","year":"2020","journal-title":"J Infect"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1148\/radiology.205.2.9356630","article-title":"Mosaic attenuation pattern on thin-section CT scans of the lung: differentiation among infiltrative lung, airway and vascular diseases as a cause","volume":"205","author":"S A Wortly","year":"1997","journal-title":"Radiology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1055\/s-0039-3399559","article-title":"Pneumocystis jiroveci","volume":"41","author":"J A Fishman","year":"2020","journal-title":"Semin Respir Crit Care Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/334519a0","article-title":"Ribosomal RNA sequence shows Pneumocystis carinii to be a member of the fungi","volume":"334","author":"J C Edman","year":"1988","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1128\/CMR.17.4.770-782.2004","article-title":"Prevention of infection due to Pneumocystis spp. in human immunodeficiency virus-negative immunocompromised patients","volume":"17","author":"M Rodriguez","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"ref8","first-page":"18","article-title":"Pneumocystis-jiroveci-Pneumonie (PcP) bei Patienten mit rheumatologischen Erkrankungen. 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